Extramammary Paget disease (EMPD) is a rare neoplasm usually presenting in the anogenital area, most commonly in the vulva. Adnexal involvement in primary EMPD is a very common feature and serves as a pathway for carcinoma to spread into deeper tissue. The depth of carcinomatous spread along the appendages and the patterns of adnexal involvement were studied in 178 lesions from 146 patients with primary EMPD. Hair follicles and eccrine ducts were the adnexa most commonly affected by carcinoma cells. The maximal depth of involvement was 3.6 mm in this series. When planning topical therapy or developing novel local treatment modalities for EMPD, this potential for significant deep spread along adnexa should be taken into account.
- MeSH
- biopsie MeSH
- dospělí MeSH
- ekrinní žlázy patologie MeSH
- extramamární Pagetova nemoc patologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory anu patologie terapie MeSH
- nádory kožních adnex patologie terapie MeSH
- nádory potních žláz patologie terapie MeSH
- nádory vulvy patologie terapie MeSH
- prognóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vlasový folikul patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa MeSH
- Západní Austrálie MeSH
