Copper (Cu) is a vital redox dynamic metal that is possibly poisonous in superfluous. Metals can traditionally or intricately cause propagation in reactive oxygen species (ROS) accretion in cells and this may effect in programmed cell death. Accumulation of Cu causes necrosis that looks to be facilitated by DNA damage, followed by activation of P53. Cu dyshomeostasis has also been concerned in neurodegenerative disorders such as Alzheimer, Amyotrophic lateral sclerosis (ALS) or Menkes disease and is directly related to neurodegenerative syndrome that usually produces senile dementia. These mortal syndromes are closely related with an immense damage of neurons and synaptic failure in the brain. This review focuses on copper mediated neurological disorders with insights into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.
- MeSH
- Alzheimerova nemoc etiologie patologie MeSH
- amyotrofická laterální skleróza etiologie patologie MeSH
- lidé MeSH
- měď škodlivé účinky MeSH
- Menkesova choroba etiologie patologie MeSH
- mozek metabolismus patologie MeSH
- oxidační stres MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- hemochromatóza farmakoterapie patologie MeSH
- hepatolentikulární degenerace etiologie farmakoterapie patologie MeSH
- játra patofyziologie patologie MeSH
- měď metabolismus škodlivé účinky MeSH
- Menkesova choroba etiologie farmakoterapie patologie MeSH
- vrozené poruchy metabolismu kovů genetika metabolismus MeSH
- zinek aplikace a dávkování terapeutické užití MeSH
