9-(2,3-dihydroxypropyl)adenine OR C016391
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Lipases from Geotrichum candidum 4013 (extracellular lipase and cell-bound lipase) were immobilized by adsorption on chitosan beads. The enzyme preparations were tested in the synthesis of ester prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine in dimethylformamide with different vinyl esters (acetate, butyrate, decanoate, laurate, palmitate). The transesterification activities of these immobilized enzymes were compared with commercially available lipases (lipase from hog pancreas, Aspergillus niger, Candida antarctica, Pseudomonas fluorescens). Lipase from Candida antarctica was found to be the most efficient enzyme regarding chemical yield of the desired products, while transesterification by lipase from Aspergillus niger resulted in lower yields.
- MeSH
- adenin * analogy a deriváty chemická syntéza chemie MeSH
- chitosan chemie MeSH
- enzymy imobilizované chemie metabolismus MeSH
- esterifikace MeSH
- estery chemie MeSH
- Geotrichum enzymologie MeSH
- lipasa chemie izolace a purifikace MeSH
- prekurzory léčiv * chemická syntéza chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
