We present a method for the amination of enolizable and non-enolizable ketones in the alpha (or beta) position to the carbonyl group. This approach is based on the conversion of the corresponding cyanohydrins to carbonazidates, precursors for thermal intramolecular nitrene insertion reactions into the adjacent C-H bond. Hydrolysis of the resulting carbamates under basic conditions with simultaneous regeneration of the carbonyl group yields amino ketones.
- Publikační typ
- časopisecké články MeSH
Edice IR
Vydání 1. 340 stran : ilustrace ; 21 cm
Publikace se zaměřuje na dezinformace, propagandu, politiku a farmaceutické společnosti a jejich vztah k nedávným pandemiím. Určeno široké veřejnosti.
- MeSH
- dějiny 21. století MeSH
- dezinformace MeSH
- farmaceutický průmysl MeSH
- komunikační média MeSH
- pandemie MeSH
- politika MeSH
- strach MeSH
- vakcinace MeSH
- Check Tag
- dějiny 21. století MeSH
- Publikační typ
- monografie MeSH
- populární práce MeSH
- Konspekt
- Sociální procesy
- NLK Obory
- sociologie
Beckova edice komentované zákony
3. vydání xxv, 1173 stran ; 23 cm
Publikace obsahuje komentář českých zákonů, které se týkají odpovědnosti za přestupky. Určeno odborné veřejnosti.
- MeSH
- právní odpovědnost MeSH
- řízení společenských procesů zákonodárství a právo MeSH
- trestní zákon MeSH
- Publikační typ
- komentáře MeSH
- Geografické názvy
- Česká republika MeSH
- Konspekt
- Ústavní právo. Správní právo
- NLK Obory
- právo, zákonodárství
- NLK Publikační typ
- zákony
Jessenius
Třetí aktualizované a doplněné vydání 227 stran : barevné ilustrace ; 20 cm
Příručka, která se zaměřuje na sportovní aktivitu u pacientů s diabetem mellitus. Obsahuje i kazuistiky. Určeno odborné veřejnosti.
- MeSH
- diabetes mellitus MeSH
- selfmonitoring glykemie MeSH
- sportovci MeSH
- sporty MeSH
- tělesná námaha MeSH
- tělesná výkonnost MeSH
- Publikační typ
- kazuistiky MeSH
- příručky MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- diabetologie
- tělovýchovné lékařství
- NLK Publikační typ
- kolektivní monografie
svazky : ilustrace ; 30 cm
Sborník prací přednesených na kongresu, který se zaměřil na angiologii. Určeno odborné veřejnosti.
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- angiologie
BACKGROUND: The number of mobile apps tailored for people living with mental health conditions has increased tremendously. However, the majority of the existing apps are not evidence-based and are being developed by teams without mental health expertise. OBJECTIVE: We aimed to explore psychiatrists' perceptions of what they and their patients need in a mental health app and eventually inform the design of future mobile apps in this area. METHODS: Semi-structured interviews were conducted with psychiatrists (N = 18) from three European countries: Austria, the Czech Republic, and Slovakia. Content analysis using inductive and deductive coding was used to analyze the interviews. RESULTS: Four major themes were deductively identified: current system, gaps in the current system, recommendations for a mobile app, and promoting app use. Psychiatrists provided a comprehensive list of app features they suggested would be helpful. Of particular importance seemed to be enabling patients to self-monitor various aspects of their lives and including an emergency plan. Participants also emphasized that the app should be positive and motivating for patients to use, with some suggesting that users be able to communicate with other users for support. Within the theme of "current system," a common topic was the current shortage of psychiatrists and the feelings of time pressure amongst existing psychiatrists. CONCLUSIONS: The results of this study can be used by software developers to inform future designs of mental health mobile apps, which will hopefully translate to a greater availability of evidence-based apps that address clinical needs.
- Publikační typ
- časopisecké články MeSH
Jessenius
2. aktualizované vydání 678 stran : ilustrace ; 21 cm
Publikace se zaměřuje na terapii duševních poruch a stavů pomocí psychotropních látek. Určeno odborné veřejnosti.
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- psychofarmakologie
- farmakoterapie
- NLK Publikační typ
- kolektivní monografie
This study aimed to directly compare electroencephalography (EEG) whole-brain patterns of neural dynamics with concurrently measured fMRI BOLD data. To achieve this, we aim to derive EEG patterns based on a spatio-spectral decomposition of band-limited EEG power in the source-reconstructed space. In a large dataset of 72 subjects undergoing resting-state hdEEG-fMRI, we demonstrated that the proposed approach is reliable in terms of both the extracted patterns as well as their spatial BOLD signatures. The five most robust EEG spatio-spectral patterns not only include the well-known occipital alpha power dynamics, ensuring consistency with established findings, but also reveal additional patterns, uncovering new insights into brain activity. We report and interpret the most reproducible source-space EEG-fMRI patterns, along with the corresponding EEG electrode-space patterns, which are better known from the literature. The EEG spatio-spectral patterns show weak, yet statistically significant spatial similarity to their functional magnetic resonance imaging (fMRI) blood oxygenation level-dependent (BOLD) signatures, particularly in the patterns that exhibit stronger temporal synchronization with BOLD. However, we did not observe a statistically significant relationship between the EEG spatio-spectral patterns and the classical fMRI BOLD resting-state networks (as identified through independent component analysis), tested as the similarity between their temporal synchronization and spatial overlap. This provides evidence that both EEG (frequency-specific) power and the BOLD signal capture reproducible spatio-temporal patterns of neural dynamics. Instead of being mutually redundant, these only partially overlap, providing largely complementary information regarding the underlying low-frequency dynamics.
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Stage 1 hypertension influences acute cardiovascular responses to resistance exercises and post-exercise recovery. We examined whether the order of exercises, particularly in agonist-antagonist pairings, can alter these cardiovascular responses. This study compares systolic and diastolic blood pressure responses during agonist and agonist-antagonist paired sets of upper and lower-body resistance exercises with a load of 75% repetition maximum in individuals with normotension and stage 1 hypertension. METHODS: A cross-sectional study enrolled 47 participants with sedentary jobs, comprising 30 normotensive individuals (47.8 ± 5.9 years, height 174.8 ± 10.2 cm, weight 77.7 ± 15.4 kg, BMI 25.3 ± 3.6 kg/m2) and 17 hypertensive individuals (54.3 ± 6.0 years, 177.6 ± 11.3 cm, 89.8 ± 16.4 kg, BMI 28.5 ± 4,5 kg/m2). Acute cardiovascular parameters were measured using an arteriograph, a non-invasive device designed to assess vascular stiffness and cardiovascular health, after each set of resistance training. RESULTS: No significant differences in systolic blood pressure changes were found between the resistance training methods and aerobic exercise when comparing normotensive and hypertensive individuals. However, significant increases in systolic blood pressure were observed during lower-body exercises (11.3-24.7 mmHg for normotensives and 11.7-24.1 mmHg for hypertensives, p < 0.05). Hypertensive individuals showed slightly higher increases during lower-body supersets (p < 0.05). Regarding diastolic blood pressure, significant decreases were noted during upper-body resistance training for both groups, especially for normotensives (-10.6 to -13.7 mmHg, p < 0.05). CONCLUSIONS: Agonist and agonist-antagonist paired set resistance training for both lower and upper-body exercises resulted in similar blood pressure changes in individuals with normotension and stage 1 hypertension. These findings suggest that both methods may have comparable cardiovascular effects across blood pressure. TRIAL REGISTRATION: The study was registered on ClinicalTrials.gov (NCT06047678). Registration date: 31 August 2023.
- Publikační typ
- časopisecké články MeSH
