Paulownia tomentosa is a large indecidous tree planted mostly for its fast growing wood and decorative purposes. The tree is also used in traditional Chinese medicine. As a part of our study of natural polyphenols, the fruits of Paulownia tomentosa were extracted by EtOH and than subjected to liquid/liquid extraction. Fractions were analysed by TLC and HPLC to determine presence of phenolic substances. We identified and quantified acteoside (1) and isoacteoside (2) in the EtOAc and n-BuOH extracts; mimulone (3) and diplacone (4) in the MeOH extract. To determine the antiradical activity of extracts we used the anti DPPH and peroxynitrite assays. The activity was expressed as Trolox C equivalents, IC50 for DPPH scavenging and a time dependency course was established. The polyphenols content was determined; results were expressed as gallic acid equivalents. Using these methods we found the fractions of the n-BuOH, EtOAc and MeOH extracts that display antiradical activity, which could be exploited as potential pharmaceuticals.

• MeSH
• fenoly farmakologie   izolace a purifikace   MeSH
• financování organizované MeSH
• flavonoidy farmakologie   izolace a purifikace   MeSH
• léčivé rostliny MeSH
• léky rostlinné čínské farmakologie   izolace a purifikace   MeSH
• ovoce chemie   MeSH
• rozpouštědla MeSH
• scavengery volných radikálů farmakologie   izolace a purifikace   MeSH
• stromy MeSH