A series of novel 9-, 7- and 3-substituted 2- or 6-guanidinopurines as analogues of potent antiviral and immunobiologically active compound enantiomers of PMPDAP was synthesized and evaluated for their biological activity. Compounds containing the combination of guanidino and amino group at the purine moiety enhanced the interferon-gamma-triggered NO production in murine macrophages and stimulated the secretion of cytokines and chemokines in both murine macrophages and human peripheral blood mononuclear cells. The most active compounds are 27 and 54. None of the compounds tested exhibited any significant cytostatic effect or antiviral effect.

• MeSH
• adenin MeSH
• adjuvancia imunologická farmakologie   chemická syntéza   chemie   MeSH
• chemokiny analýza   krev   MeSH
• cytokiny analýza   krev   MeSH
• financování organizované MeSH
• guanidiny chemická syntéza   chemie   imunologie   MeSH
• lidé MeSH
• molekulární struktura MeSH
• myši inbrední C57BL MeSH
• myši MeSH
• organofosforové sloučeniny chemická syntéza   chemie   imunologie   MeSH
• oxid dusnatý analýza   biosyntéza   MeSH
• peritoneální makrofágy účinky léků   MeSH
• techniky kombinatorické chemie MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• ženské pohlaví MeSH
• zvířata MeSH