In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity and tested for their photosynthesis-inhibiting activity using spinach (Spinacia oleracea L.) chloroplasts. All the synthesized compounds were also evaluated for antifungal activity using in vitro screening with eight fungal strains. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).

• MeSH
• antifungální látky chemie   MeSH
• chinolony farmakologie   chemická syntéza   MeSH
• chloroplasty účinky léků   MeSH
• financování organizované MeSH
• fotosyntéza účinky léků   MeSH
• houby účinky léků   MeSH
• hydrofobní a hydrofilní interakce MeSH
• hydroxychinoliny farmakologie   chemická syntéza   MeSH
• vztahy mezi strukturou a aktivitou MeSH