This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (PZQ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post-treatment. The estimated 96-hr LC50 of PZQ was 28.6 mg/L. For evaluation of efficacy, barbel naturally infected with D. spathaceum were exposed to a 10 and 20 mg/L PZQ 4-day bath treatment. Both concentrations were 100% effective against D. spathaceum and significantly (p < .01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione-S-transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered PZQ was assessed in adult barbel naturally infected with P. laevis. Fish were administered 10, 30 and 50 mg/kg of body weight and examined via gut dissection after 6 days. The 50 mg/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with D. spathaceum and has potential for oral treatment of broodfish infected with P. laevis.

• MeSH
• Acanthocephala účinky léků   MeSH
• anthelmintika farmakologie   toxicita   MeSH
• antioxidancia metabolismus   MeSH
• Cyprinidae fyziologie   MeSH
• helmintózy zvířat parazitologie   prevence a kontrola   MeSH
• infekce červy třídy Trematoda parazitologie   prevence a kontrola   veterinární   MeSH
• náhodné rozdělení MeSH
• nemoci ryb parazitologie   prevence a kontrola   MeSH
• oxidační stres účinky léků   MeSH
• praziquantel farmakologie   toxicita   MeSH
• Trematoda účinky léků   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH