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Autor
Agodi, Antonella 1 Biesiada, Grażyna 1 Brzozowski, Bartosz 1 Czepiel, Jacek 1 Deptuła, Aleksander 1 Enoch, David A 1 Fedewicz, Marcin 1 Filipczak-Bryniarska, Iwona 1 Garlicki, Aleksander 1 Goldman-Mazur, Sarah 1 Gouliouris, Theodore 1 Jurczyszyn, Artur 1 Khanafer, Nagham 1 Konturek, Katarzyna 1 Krutova, Marcela 1 Krzanowski, Marcin 1 Kuijper, Ed J 1 Michalak, Mateusz 1 Mizrahi, Assaf 1 Monpierre, Lorra 1
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Pracoviště
Centre International de Recherche en ... 1 Centre for Infectious Diseases Resear... 1 Clinical Microbiology and Public Heal... 1 Critical Care Department Vall d'Hebro... 1 Department of Gastroenterology and He... 1 Department of Hematology Jagiellonian... 1 Department of Infectious and Tropical... 1 Department of Internal and Geriatric ... 1 Department of Medical Microbiology Ce... 1 Department of Medical Microbiology Ch... 1 Department of Medical Microbiology Me... 1 Department of Medical and Surgical Sc... 1 Department of Metabolic Diseases Jagi... 1 Department of Nephrology and Dialysis... 1 Department of Pain Treatment and Pall... 1 Department of Propaedeutics of Medici... 1 ESCMID Study Group for Clostridioides... 1 Hygienic Department Bács Kiskun Count... 1 Institut Micalis UMR 1319 Université ... 1 Intensive Care Unit University Hospit... 1
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Autor
Agodi, Antonella 1 Biesiada, Grażyna 1 Brzozowski, Bartosz 1 Czepiel, Jacek 1 Deptuła, Aleksander 1 Enoch, David A 1 Fedewicz, Marcin 1 Filipczak-Bryniarska, Iwona 1 Garlicki, Aleksander 1 Goldman-Mazur, Sarah 1 Gouliouris, Theodore 1 Jurczyszyn, Artur 1 Khanafer, Nagham 1 Konturek, Katarzyna 1 Krutova, Marcela 1 Krzanowski, Marcin 1 Kuijper, Ed J 1 Michalak, Mateusz 1 Mizrahi, Assaf 1 Monpierre, Lorra 1
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Pracoviště
Centre International de Recherche en ... 1 Centre for Infectious Diseases Resear... 1 Clinical Microbiology and Public Heal... 1 Critical Care Department Vall d'Hebro... 1 Department of Gastroenterology and He... 1 Department of Hematology Jagiellonian... 1 Department of Infectious and Tropical... 1 Department of Internal and Geriatric ... 1 Department of Medical Microbiology Ce... 1 Department of Medical Microbiology Ch... 1 Department of Medical Microbiology Me... 1 Department of Medical and Surgical Sc... 1 Department of Metabolic Diseases Jagi... 1 Department of Nephrology and Dialysis... 1 Department of Pain Treatment and Pall... 1 Department of Propaedeutics of Medici... 1 ESCMID Study Group for Clostridioides... 1 Hygienic Department Bács Kiskun Count... 1 Institut Micalis UMR 1319 Université ... 1 Intensive Care Unit University Hospit... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Czepiel, Jacek
- Krutova, Marcela
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Mizrahi, Assaf
Autor Mizrahi, Assaf ESCMID Study Group for Clostridioides Difficile (ESGCD), 4001 Basel, Switzerland Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, 75014 Paris, France Institut Micalis UMR 1319, Université Paris-Saclay, INRAe, AgroParisTech, 92290 Châtenay Malabry, France
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Khanafer, Nagham
Autor Khanafer, Nagham ESCMID Study Group for Clostridioides Difficile (ESGCD), 4001 Basel, Switzerland Unité d'Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Centre, Hospices Civils de Lyon, 69002 Lyon, France Centre International de Recherche en Infectiologie (CIRI), Public Health, Epidemiology and Evolutionary Ecology of Infectious Diseases (PHE3ID), Université de Lyon, 69372 Lyon, France
- Enoch, David A
- Patyi, Márta
- Deptuła, Aleksander
- Agodi, Antonella
- Nuvials, Xavier
- Pituch, Hanna
NLK
Directory of Open Access Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
33805755
DOI
10.3390/antibiotics10030299
Knihovny.cz E-zdroje
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospective case-control study conducted in nine hospitals from seven European countries. A total of 624 patients were included, of which 415 were deceased (cases) and 209 were still alive 90 days after a CDI diagnosis (controls). The most common antibiotics used previously in both groups were β-lactams; previous exposure to fluoroquinolones was significantly (p = 0.0004) greater in deceased patients. Multivariate logistic regression showed that the factors independently related with death during CDI were older age, inadequate CDI therapy, cachexia, malignancy, Charlson Index, long-term care, elevated white blood cell count (WBC), C-reactive protein (CRP), bacteraemia, complications, and cognitive impairment. In addition, older age, higher levels of WBC, neutrophil, CRP or creatinine, the presence of malignancy, cognitive impairment, and complications were strongly correlated with shortening the time from CDI diagnosis to death. CDI prevention should be primarily focused on hospitalised elderly people receiving antibiotics. WBC, neutrophil count, CRP, creatinine, albumin and lactate levels should be tested in every hospitalised patient treated for CDI to assess the risk of a fatal outcome.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.