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Beijing Advanced Innovation Center fo... 1 Center of Oral Implantology Stomatolo... 1 Department of Oral and Maxillofacial ... 1 Department of Orthodontics Stomatolog... 1 Department of Periodontology Stomatol... 1 Department of Prosthodontics School a... 1 FZU the Institute of Physics Czech Ac... 1 Institute of Advanced Wear and Corros... 1 Key Laboratory of Advanced Technologi... 1 National Engineering Laboratory for D... 1 School and Hospital of Stomatology Gu... 1 Section Medical Materials Science and... 1
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Beijing Advanced Innovation Center fo... 1 Center of Oral Implantology Stomatolo... 1 Department of Oral and Maxillofacial ... 1 Department of Orthodontics Stomatolog... 1 Department of Periodontology Stomatol... 1 Department of Prosthodontics School a... 1 FZU the Institute of Physics Czech Ac... 1 Institute of Advanced Wear and Corros... 1 Key Laboratory of Advanced Technologi... 1 National Engineering Laboratory for D... 1 School and Hospital of Stomatology Gu... 1 Section Medical Materials Science and... 1
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Li, Ping
Autor Li, Ping Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, South Jiangnan Road No. 366, Guangzhou 510280, China School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China Department of Prosthodontics, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China
- Dai, Jingtao
- Li, Yageng
- Alexander, Dorothea
- Čapek, Jaroslav
- Geis-Gerstorfer, Jürgen
- Wan, Guojiang
- Han, Jianmin
- Yu, Zhentao
- Li, An
PubMed Central od 2019
Elsevier Open Access Journals od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources od 2019
PubMed
38298560
DOI
10.1016/j.mtbio.2023.100932
Knihovny.cz E-zdroje
Bone fractures and critical-size bone defects are significant public health issues, and clinical treatment outcomes are closely related to the intrinsic properties of the utilized implant materials. Zinc (Zn)-based biodegradable metals (BMs) have emerged as promising bioactive materials because of their exceptional biocompatibility, appropriate mechanical properties, and controllable biodegradation. This review summarizes the state of the art in terms of Zn-based metals for bone repair and regeneration, focusing on bridging the gap between biological mechanism and required bioactivity. The molecular mechanism underlying the release of Zn ions from Zn-based BMs in the improvement of bone repair and regeneration is elucidated. By integrating clinical considerations and the specific bioactivity required for implant materials, this review summarizes the current research status of Zn-based internal fixation materials for promoting fracture healing, Zn-based scaffolds for regenerating critical-size bone defects, and Zn-based barrier membranes for reconstituting alveolar bone defects. Considering the significant progress made in the research on Zn-based BMs for potential clinical applications, the challenges and promising research directions are proposed and discussed.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.