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Autor
Ambrose, Pauline 1 Bousema, Teun 1 Chatterjee, Arnab K 1 Dechering, Koen J 1 Duerr, Hans-Peter 1 Eldering, Maarten 1 Ferguson, Neil 1 Jancarova, Magdalena 1 Koenraadt, Constantianus J M 1 Koolen, Karin M J 1 Lees, Rosemary S 1 Miglianico, Marie 1 Pruzinova, Katerina 1 Sauerwein, Robert W 1 Schultz, Peter G 1 Slater, Hannah 1 Sturm, Angelika 1 Tremblay, Matthew S 1 Trevitt, Graham 1 Volf, Petr 1
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Pracoviště
California Institute for Biomedical R... 1 Department of Medical Microbiology Ra... 1 Department of Parasitology Faculty of... 1 Laboratory of Entomology Wageningen U... 1 MRC Centre for Outbreak Analysis and ... 1 Numerus Ltd RG40 2AY Tübingen Germany 1 The Liverpool Insect Testing Establis... 1 TropIQ Health Sciences 6534 Nijmegen ... 1 TropIQ Health Sciences 6534 Nijmegen ... 1 XenoGesis Ltd Nottingham NG1 1GF Unit... 1
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Autor
Ambrose, Pauline 1 Bousema, Teun 1 Chatterjee, Arnab K 1 Dechering, Koen J 1 Duerr, Hans-Peter 1 Eldering, Maarten 1 Ferguson, Neil 1 Jancarova, Magdalena 1 Koenraadt, Constantianus J M 1 Koolen, Karin M J 1 Lees, Rosemary S 1 Miglianico, Marie 1 Pruzinova, Katerina 1 Sauerwein, Robert W 1 Schultz, Peter G 1 Slater, Hannah 1 Sturm, Angelika 1 Tremblay, Matthew S 1 Trevitt, Graham 1 Volf, Petr 1
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Pracoviště
California Institute for Biomedical R... 1 Department of Medical Microbiology Ra... 1 Department of Parasitology Faculty of... 1 Laboratory of Entomology Wageningen U... 1 MRC Centre for Outbreak Analysis and ... 1 Numerus Ltd RG40 2AY Tübingen Germany 1 The Liverpool Insect Testing Establis... 1 TropIQ Health Sciences 6534 Nijmegen ... 1 TropIQ Health Sciences 6534 Nijmegen ... 1 XenoGesis Ltd Nottingham NG1 1GF Unit... 1
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Freely Accessible Science Journals od 1915 do Před 6 měsíci
PubMed Central od 1915 do Před 6 měsíci
Europe PubMed Central od 1915 do Před 6 měsíci
Open Access Digital Library od 1915-01-01
Open Access Digital Library od 1915-01-15
PubMed
29967151
DOI
10.1073/pnas.1801338115
Knihovny.cz E-zdroje
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Aedes, and Culex mosquitoes and Phlebotomus sand flies after feeding on a drug-supplemented blood meal, with IC50 values ranging from 33 to 575 nM, and were fully active against strains with preexisting resistance to common insecticides. Based on allometric scaling of preclinical pharmacokinetics data, we predict that a single human median dose of 260 mg (IQR, 177-407 mg) for afoxolaner, or 410 mg (IQR, 278-648 mg) for fluralaner, could provide an insecticidal effect lasting 50-90 days against mosquitoes and Phlebotomus sand flies. Computational modeling showed that seasonal mass drug administration of such a single dose to a fraction of a regional population would dramatically reduce clinical cases of Zika and malaria in endemic settings. Isoxazolines therefore represent a promising new component of drug-based vector control.
- MeSH
- Culicidae růst a vývoj MeSH
- insekticidy farmakologie MeSH
- komáří přenašeči růst a vývoj MeSH
- kontrola infekčních nemocí metody MeSH
- lidé MeSH
- moskyti - kontrola metody MeSH
- Psychodidae růst a vývoj MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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