BACKGROUND: The quality of one's facial appearance diminishes with aging as skin and underlying soft tissues deteriorate. Connective tissue and musculofascial degeneration leads to skin laxity and wrinkles developing. OBJECTIVE: To evaluate the effects of synchronized radiofrequency with high intensity facial stimulation technology on dermal collagen and elastin fibers in a porcine model. MATERIALS AND METHODS: Eight sows were divided into Active (N = 6) and Control (N = 2) groups. Synchronized radiofrequency and high intensity facial stimulation were delivered to the ventrolateral abdomen. The Active group received four 20-minute treatments, once a week. Control group was untreated. Skin biopsy sample were histologically analyzed for connective tissue changes pre- and post-treatment. Data were analyzed statistically (α = 0.05). RESULTS: In the Active group: the collagen-occupied area at baseline was 1.12 ± 0.09 × 106 μm 2 and increased by +19.6% ( p < .001) at 1-month and by +26.3% ( p < .001) 2 months post-treatment; elastin-occupied area at baseline was 0.11 ± 0.03 × 106 μm 2 and increased by +75.9% ( p < .001) at 1-month and +110.8% ( p < .001) at 2-months follow-up. No significant changes ( p > .05) found in the Control samples. CONCLUSION: Collagen and elastin fiber content increased significantly after treatments. Connective tissue in the treatment area was denser up to 2-months post-treatment.
- MeSH
- elastin MeSH
- kolagen MeSH
- kůže MeSH
- modely u zvířat MeSH
- obličejové svaly * MeSH
- prasata MeSH
- stárnutí kůže * MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The demand for noninvasive body contouring procedures continues to drive the development of new technology to treat areas on the body that are more resistant to diet and exercise. This study assesses the safety and efficacy of a novel selective RF applicator as a noninvasive, contactless method for reducing thigh circumference using a radiofrequency electric field (Vanquish Flex Applicator, BTL Industries Inc., Boston, MA). Forty-two female subjects were enrolled to undergo a treatment of their bilateral inner and outer thighs (saddle bags) once weekly for 4 weeks. Thigh circumference was measured at the baseline and 2 weeks after the fourth treatment. The primary objective was the evaluation of clinical outcomes of 40 treated subjects. Safety of the device was assessed based on adverse events reports during the course of the study. Forty subjects completed the study. After four treatments, the therapy group showed a statistically significant (p < 0.001) reduction in thigh circumference of 2.43 cm compared with an untreated control group of 10 patients, where no change was seen (p = 0.297). No treatment associated pain or discomfort was reported by the subjects. There were also no reports of adverse events. This study demonstrates that the contactless RF Applicator is safe, painless and effective for the circumferential reduction of the thighs.
- MeSH
- dospělí MeSH
- kosmetické techniky * přístrojové vybavení MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- radiofrekvenční terapie MeSH
- rádiové vlny škodlivé účinky MeSH
- stehno * MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
The aesthetic market offers various radiofrequency treatments for the reduction of wrinkles and rhytids. Even though this not an uncommon aesthetic therapy, there is considerable lack of clinical evidence on the various energy delivery systems available (unipolar, bipolar, tripolar, multipolar, etc.). The purpose of this study was to demonstrate the efficacy of a monopolar radiofrequency device (Exilis Elite, BTL Industries Inc., Boston, MA, USA) on the skin collagen in an animal model. The study treatment was done on the abdominal area of the potbellied Vietnamese mini pigs in the Veterinary Research Institute facility. All pigs were treated once per week for 4 weeks. The treatment area was sized 20 × 10 cm. The surface temperature was kept in the therapeutic interval from 39 °C to 43 °C and the therapy lasted for 10 minutes after reaching the therapeutic temperature. Biopsy samples were taken before the therapy and at the 3-month follow-up. The histology samples were stained and magnified (×400) before computer processing. The collagen volume was calculated using the stereological analysis and the data were statistically processed (using the nonparametric two-sample t-test). The collagen content tissue increased from average of 9.0% before the therapy up to 25.9% after the 3-month follow-up period. The statistical comparison of 54 samples taken before and after the treatment acknowledged the significant difference (p = 0.018). The stereological analysis proved large-scale improvement of collagen in the treated area. We have observed that the monopolar radiofrequency therapy significantly increases collagen remodeling.
- MeSH
- časové faktory MeSH
- design vybavení MeSH
- elektrostimulační terapie přístrojové vybavení MeSH
- kolagen metabolismus MeSH
- kosmetické techniky přístrojové vybavení MeSH
- kůže metabolismus účinky záření MeSH
- miniaturní prasata MeSH
- modely u zvířat MeSH
- prasata MeSH
- rádiové vlny * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
