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Autor
Bontems, François 1 Bouvin-Pley, Mélanie 1 Braibant, Martine 1 Di Santo, James P 1 Dimitrov, Jordan D 1 Fernández, Ignacio 1 Fiquet, Oriane 1 Girelli-Zubani, Giulia 1 Guivel-Benhassine, Florence 1 Hieu, Thierry 1 Hrebík, Dominik 1 Lorin, Valérie 1 Masse-Ranson, Guillemette 1 Molinos-Albert, Luis M 1 Mouquet, Hugo 1 Planchais, Cyril 1 Plevka, Pavel 1 Péhau-Arnaudet, Gérard 1 Rey, Félix A 1 Sanders, Rogier W 1
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Pracoviště
Beth Israel Deaconess Medical Center ... 1 Central European Institute of Technol... 1 Centre de Recherche des Cordeliers In... 1 Centre national de la recherche scien... 1 Department of Medical Microbiology Am... 1 Department of Microbiology and Immuno... 1 Imagopole Plate Forme de Microscopie ... 1 Innate Immunity Unit Department of Im... 1 Institut de Chimie des Substances Nat... 1 Institut national de la santé et de l... 1 Institut national de la santé et de l... 1 Laboratory of Humoral Immunology Depa... 1 Laboratory of Molecular Immunology Th... 1 Partners AIDS Research Center Massach... 1 Ragon Institute of Massachusetts Gene... 1 Structural Virology Unit Department o... 1 Université de Paris Sorbonne Paris Ci... 1 Université de Tours Institut national... 1 Virus and Immunity Unit Department of... 1
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Autor
Bontems, François 1 Bouvin-Pley, Mélanie 1 Braibant, Martine 1 Di Santo, James P 1 Dimitrov, Jordan D 1 Fernández, Ignacio 1 Fiquet, Oriane 1 Girelli-Zubani, Giulia 1 Guivel-Benhassine, Florence 1 Hieu, Thierry 1 Hrebík, Dominik 1 Lorin, Valérie 1 Masse-Ranson, Guillemette 1 Molinos-Albert, Luis M 1 Mouquet, Hugo 1 Planchais, Cyril 1 Plevka, Pavel 1 Péhau-Arnaudet, Gérard 1 Rey, Félix A 1 Sanders, Rogier W 1
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Pracoviště
Beth Israel Deaconess Medical Center ... 1 Central European Institute of Technol... 1 Centre de Recherche des Cordeliers In... 1 Centre national de la recherche scien... 1 Department of Medical Microbiology Am... 1 Department of Microbiology and Immuno... 1 Imagopole Plate Forme de Microscopie ... 1 Innate Immunity Unit Department of Im... 1 Institut de Chimie des Substances Nat... 1 Institut national de la santé et de l... 1 Institut national de la santé et de l... 1 Laboratory of Humoral Immunology Depa... 1 Laboratory of Molecular Immunology Th... 1 Partners AIDS Research Center Massach... 1 Ragon Institute of Massachusetts Gene... 1 Structural Virology Unit Department o... 1 Université de Paris Sorbonne Paris Ci... 1 Université de Tours Institut national... 1 Virus and Immunity Unit Department of... 1
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NLK
Free Medical Journals
od 1896 do Před 6 měsíci
PubMed Central
od 1896 do Před 6 měsíci
Europe PubMed Central
od 1896 do Před 6 měsíci
Open Access Digital Library
od 1896-01-01
Open Access Digital Library
od 1896-01-01
Open Access Digital Library
od 1996-01-01
PubMed
35230385
DOI
10.1084/jem.20212045
Knihovny.cz E-zdroje
Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which comprised only IgG+ or IgA+ blood memory B cells; the third combined both IgG and IgA clonal variants. 7-269 bNAb in the IgA-only lineage displayed the highest neutralizing capacity despite limited somatic mutation, and delayed viral rebound in humanized mice. bNAbs in all three lineages targeted the N332 glycan supersite. The 2.8-Å resolution cryo-EM structure of 7-269-BG505 SOSIP.664 complex showed a similar pose as 2G12, on an epitope mainly composed of sugar residues comprising the N332 and N295 glycans. Binding and cryo-EM structural analyses showed that antibodies from the two other lineages interact mostly with glycans N332 and N386. Hence, multiple B cell lineages of IgG and IgA bNAbs focused on a unique HIV-1 site of vulnerability can codevelop in HIV-1 viremic controllers.
- MeSH
- epitopy MeSH
- genové produkty env - virus lidské imunodeficience MeSH
- HIV infekce * MeSH
- HIV protilátky MeSH
- HIV-1 * MeSH
- imunoglobulin A MeSH
- imunoglobulin G MeSH
- lidé MeSH
- myši MeSH
- neutralizující protilátky MeSH
- non-progresoři MeSH
- polysacharidy MeSH
- široce neutralizující protilátky MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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