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Autor
Avril, Tony 1 Beauchamp, Marie-Claude 1 Cazals-Hatem, Dominique 1 Chatziioannou, Aristotelis 1 Chevet, Eric 1 Daniel, Fanny 1 Delom, Frédéric 1 Ding, Yong-Ping 1 Dupont, Aurélien 1 Eriksson, Leif A 1 Fernandez-Zapico, Martin E 1 Fessart, Delphine 1 Hou, Wenyang 1 Hrstka, Roman 1 Hupp, Ted 1 Hörberg, Johanna 1 Jansen, Gregor 1 Jerome-Majewska, Loydie 1 Maurel, Marion 1 Obacz, Joanna 1
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Pracoviště
Apoptosis Research Centre School of N... 1 Biochemistry Department McGill Univer... 1 Department of Chemistry and Molecular... 1 Departments of Anatomy and Cell Biolo... 1 Division of Oncology Research Departm... 1 INSERM U1242 Chemistry Oncogenesis St... 1 INSERM U1242 Chemistry Oncogenesis St... 1 INSERM UMR1149 Team «Gut Inflammation... 1 Institute of Biology Medicinal Chemis... 1 Institute of Biology Medicinal Chemis... 1 Institute of Biology Medicinal Chemis... 1 International Centre for Cancer Vacci... 1 Microscopy Rennes Imaging Centre and ... 1 Regional Centre for Applied Molecular... 1 University of Bordeaux Bordeaux France 1 VIB Department of Medical Protein Res... 1
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Autor
Avril, Tony 1 Beauchamp, Marie-Claude 1 Cazals-Hatem, Dominique 1 Chatziioannou, Aristotelis 1 Chevet, Eric 1 Daniel, Fanny 1 Delom, Frédéric 1 Ding, Yong-Ping 1 Dupont, Aurélien 1 Eriksson, Leif A 1 Fernandez-Zapico, Martin E 1 Fessart, Delphine 1 Hou, Wenyang 1 Hrstka, Roman 1 Hupp, Ted 1 Hörberg, Johanna 1 Jansen, Gregor 1 Jerome-Majewska, Loydie 1 Maurel, Marion 1 Obacz, Joanna 1
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Pracoviště
Apoptosis Research Centre School of N... 1 Biochemistry Department McGill Univer... 1 Department of Chemistry and Molecular... 1 Departments of Anatomy and Cell Biolo... 1 Division of Oncology Research Departm... 1 INSERM U1242 Chemistry Oncogenesis St... 1 INSERM U1242 Chemistry Oncogenesis St... 1 INSERM UMR1149 Team «Gut Inflammation... 1 Institute of Biology Medicinal Chemis... 1 Institute of Biology Medicinal Chemis... 1 Institute of Biology Medicinal Chemis... 1 International Centre for Cancer Vacci... 1 Microscopy Rennes Imaging Centre and ... 1 Regional Centre for Applied Molecular... 1 University of Bordeaux Bordeaux France 1 VIB Department of Medical Protein Res... 1
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Maurel, Marion
Autor Maurel, Marion INSERM U1242, "Chemistry, Oncogenesis Stress Signaling", University of Rennes, Rennes, France. Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France. VIB Department of Medical Protein Research, UGent, Gent, Belgium. Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland
- Obacz, Joanna
- Avril, Tony
- Ding, Yong-Ping
- Papadodima, Olga
- Treton, Xavier
- Daniel, Fanny
- Pilalis, Eleftherios
- Hörberg, Johanna
- Hou, Wenyang
NLK
Directory of Open Access Journals
od 2009
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-04-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Medline Complete (EBSCOhost)
od 2011-01-01
Health & Medicine (ProQuest)
od 2009-04-01
ROAD: Directory of Open Access Scholarly Resources
od 2008
PubMed
31040128
DOI
10.15252/emmm.201810120
Knihovny.cz E-zdroje
Anterior gradient 2 (AGR2) is a dimeric protein disulfide isomerase family member involved in the regulation of protein quality control in the endoplasmic reticulum (ER). Mouse AGR2 deletion increases intestinal inflammation and promotes the development of inflammatory bowel disease (IBD). Although these biological effects are well established, the underlying molecular mechanisms of AGR2 function toward inflammation remain poorly defined. Here, using a protein-protein interaction screen to identify cellular regulators of AGR2 dimerization, we unveiled specific enhancers, including TMED2, and inhibitors of AGR2 dimerization, that control AGR2 functions. We demonstrate that modulation of AGR2 dimer formation, whether enhancing or inhibiting the process, yields pro-inflammatory phenotypes, through either autophagy-dependent processes or secretion of AGR2, respectively. We also demonstrate that in IBD and specifically in Crohn's disease, the levels of AGR2 dimerization modulators are selectively deregulated, and this correlates with severity of disease. Our study demonstrates that AGR2 dimers act as sensors of ER homeostasis which are disrupted upon ER stress and promote the secretion of AGR2 monomers. The latter might represent systemic alarm signals for pro-inflammatory responses.
- MeSH
- endoplazmatické retikulum genetika metabolismus MeSH
- HEK293 buňky MeSH
- homeostáze proteinů * MeSH
- lidé MeSH
- mukoproteiny genetika metabolismus MeSH
- multimerizace proteinu * MeSH
- myši MeSH
- onkogenní proteiny genetika metabolismus MeSH
- stres endoplazmatického retikula * MeSH
- zvířata MeSH
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- lidé MeSH
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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