Antibodies to deamidated gliadin peptides (DGP-AGA) have newly been presented into the extensive variety of serologic examinations for celiac disease (CD). In compare with the modern AGA, DGP-AGA indicated a higher sensitivity and specificity for CD and simply identified by ELISA kits. Nevertheless, even though the very favorable outcomes, DGP-AGA are not yet regularly used in the serologic checkup for CD. An antibody approach could initiate development in the diagnostic precision of serology for CD screening.

• MeSH
• autoprotilátky krev   MeSH
• celiakie * diagnóza   prevence a kontrola   MeSH
• gliadin imunologie   MeSH
• imunoglobulin A krev   MeSH
• imunoglobulin G krev   MeSH
• lidé MeSH
• Check Tag
• lidé MeSH

Background: Celiac disease (CD) is one of the most common genetically based disease. Histological confirmation of the characteristic small bowel changes is currently considered the gold standard to establish diagnosis of CD in patients with positive antibody testing. The aim of this study is to determine the correlation between endoscopy manifestations and pathology outcome for diagnosis of CD. Materials & Methods: A total of 295 consecutive patients who were referred to our endoscopy section from March 2015 through March 2016 were enrolled into the study. All patients were underwent endoscopy, 4 biopsies were taken and their results were compared with pathology features. The relationship between age, sex, and pathology features and endoscopy manifestations were evaluated. Results: The mean age of the subjects was 46.7±15.5 years of which 147(49.8%) were female, and 148(50.2%) were male. No statistically significant correlation was showed between the age and gender with pathology features and endoscopy manifestations (p<0.05). Most patients with Marsh 1 and 2 had a normal endoscopy. CD was confirmed by serology in 3 cases (1%) with Marsh III. We did not observe significant correlation between endoscopy results and pathology features (P=0.674). Conclusions: Our data showed that endoscopy results are not specific for CD diagnosis, and biopsy should be collected in patients with suggested symptoms associated with the disease and regardless to endoscopic features.

• MeSH
• biopsie MeSH
• celiakie * diagnostické zobrazování   diagnóza   MeSH
• dospělí MeSH
• duodenoskopie MeSH
• duodenum patologie   MeSH
• gastrointestinální endoskopie MeSH
• lidé středního věku MeSH
• lidé MeSH
• střevní sliznice diagnostické zobrazování   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• Publikační typ
• pozorovací studie MeSH

• MeSH
• celiakie * imunologie   prevence a kontrola   MeSH
• kojenec MeSH
• kojení * MeSH
• lidé MeSH
• mateřské mléko * imunologie   MeSH
• přirozená imunita imunologie   MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH

• MeSH
• adaptivní imunita MeSH
• celiakie * imunologie   patofyziologie   terapie   MeSH
• gliadin metabolismus   účinky léků   MeSH
• interleukiny imunologie   terapeutické užití   MeSH
• lidé MeSH
• regulační T-lymfocyty imunologie   MeSH
• vakcíny MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• klinické zkoušky MeSH
• úvodníky MeSH

• Klíčová slova
• neceliakální glutenová senzitivita, NCGS,
• MeSH
• bezlepková dieta MeSH
• celiakie diagnóza   MeSH
• gluteny * imunologie   škodlivé účinky   MeSH
• HLA-DQ antigeny MeSH
• lidé MeSH
• nemoci střev * diagnóza   imunologie   MeSH
• potravinová alergie * diagnóza   dietoterapie   imunologie   MeSH
• protilátky krev   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• úvodní články MeSH