The enzymatic regioselective monopalmitoylation of racemic 9-(2,3-dihydroxypropyl)- adenine (DHPA), an approved antiviral agent, has been performed by an immobilized form of Candida antarctica B lipase (CAL-B) using a 4:1 DMF/hexane mixture as the reaction medium. To improve the chemical yield of the desired monopalmitoylation reaction, solid-phase chemical modifications of the lipase were evaluated. The reaction yield was successfully increased obtaining 100% product after a second treatment of the product solution with fresh immobilised chemically glycosylated-CAL-B.
- MeSH
- adenin analogy a deriváty chemie MeSH
- Candida enzymologie MeSH
- enzymy imobilizované chemie MeSH
- fungální proteiny chemie MeSH
- glykosylace MeSH
- hexany chemie MeSH
- katalýza * MeSH
- lipasa chemie MeSH
- lipoylace MeSH
- polymery chemie MeSH
- rozpouštědla chemie MeSH
- stereoizomerie MeSH
- Publikační typ
- časopisecké články MeSH
