-
Autor
Abiusi, Emanuela 1 Ahrens, Wolfgang 1 Amore, Rosarita 1 Arzani, Dario 1 Boccia, Stefania 1 Boffetta, Paolo 1 Brennan, Paul 1 Cadoni, Gabriella 1 Canova, Cristina 1 Danilo Tiziano, Francesco 1 Giraldi, Luca 1 Healy, Claire Mary 1 Holcatova, Ivana 1 Lagiou, Pagona 1 Matsuo, Keitaro 1 Nygård, Ståle 1 Oze, Isao 1 Pastorino, Roberta 1 Polesel, Jerry 1 Popovic, Maja 1
-
Pracoviště
Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit Centro di Ri... 1 Cancer Epidemiology Unit Department o... 1 Cancer Registry of Norway Oslo Norway 1 Consortium for Biomedical Research in... 1 Department of Cardiac Thoracic Vascul... 1 Department of Hygiene Epidemiology an... 1 Department of Life Sciences and Publi... 1 Department of Medical and Surgical Sc... 1 Department of Woman and Child Health ... 1 Dipartimento Patologia Testa Collo e ... 1 Dipartimento Scienze dell'Invecchiame... 1 Division of Cancer Epidemiology Nagoy... 1 Division of Cancer Epidemiology and P... 1 Institute of Hygiene and Epidemiology... 1 International Agency for Research on ... 1 Leibniz Institute for Prevention Rese... 1 Section of Hygiene University Departm... 1 Stony Brook Cancer Center Stony Brook... 1 Trinity College Dublin School of Dent... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Autor
Abiusi, Emanuela 1 Ahrens, Wolfgang 1 Amore, Rosarita 1 Arzani, Dario 1 Boccia, Stefania 1 Boffetta, Paolo 1 Brennan, Paul 1 Cadoni, Gabriella 1 Canova, Cristina 1 Danilo Tiziano, Francesco 1 Giraldi, Luca 1 Healy, Claire Mary 1 Holcatova, Ivana 1 Lagiou, Pagona 1 Matsuo, Keitaro 1 Nygård, Ståle 1 Oze, Isao 1 Pastorino, Roberta 1 Polesel, Jerry 1 Popovic, Maja 1
-
Pracoviště
Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit Centro di Ri... 1 Cancer Epidemiology Unit Department o... 1 Cancer Registry of Norway Oslo Norway 1 Consortium for Biomedical Research in... 1 Department of Cardiac Thoracic Vascul... 1 Department of Hygiene Epidemiology an... 1 Department of Life Sciences and Publi... 1 Department of Medical and Surgical Sc... 1 Department of Woman and Child Health ... 1 Dipartimento Patologia Testa Collo e ... 1 Dipartimento Scienze dell'Invecchiame... 1 Division of Cancer Epidemiology Nagoy... 1 Division of Cancer Epidemiology and P... 1 Institute of Hygiene and Epidemiology... 1 International Agency for Research on ... 1 Leibniz Institute for Prevention Rese... 1 Section of Hygiene University Departm... 1 Stony Brook Cancer Center Stony Brook... 1 Trinity College Dublin School of Dent... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Pastorino, Roberta
Autor Pastorino, Roberta ORCID Department of Woman and Child Health and Public Health-Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italia
- Sassano, Michele
-
Danilo Tiziano, Francesco
Autor Danilo Tiziano, Francesco ORCID Department of Life Sciences and Public Health, Section of Genomic Medicine, Università Cattolica del Sacro Cuore, Roma, Italia Unit of Medical Genetics, Department of Laboratory Science and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia
- Giraldi, Luca
- Amore, Rosarita
- Arzani, Dario
-
Abiusi, Emanuela
Autor Abiusi, Emanuela ORCID Department of Life Sciences and Public Health, Section of Genomic Medicine, Università Cattolica del Sacro Cuore, Roma, Italia Unit of Medical Genetics, Department of Laboratory Science and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia
- Ahrens, Wolfgang
- Vilches, Laia Alemany
- Canova, Cristina
NLK
Free Medical Journals
od 1991 do Před 1 rokem
Freely Accessible Science Journals
od 1991 do Před 12 měsíci
Open Access Digital Library
od 1991-11-01
Open Access Digital Library
od 1991-11-01
PubMed
36126276
DOI
10.1158/1055-9965.epi-22-0376
Knihovny.cz E-zdroje
BACKGROUND: Identification of screening tests for the detection of head and neck cancer (HNC) at an early stage is an important strategy to improving prognosis. Our objective was to identify plasma circulating miRNAs for the diagnosis of HNC (oral and laryngeal subsites), within a multicenter International Head and Neck Cancer Epidemiology consortium. METHODS: A high-throughput screening phase with 754 miRNAs was performed in plasma samples of 88 cases and 88 controls, followed by a validation phase of the differentially expressed miRNAs, identified in the screening, in samples of 396 cases and 396 controls. Comparison of the fold changes (FC) was carried out using the Wilcoxon rank-sum test and the Dunn multiple comparison test. RESULTS: We identified miR-151-3p (FC = 1.73, P = 0.007) as differentially expressed miRNAs in the screening and validation phase. The miR-151-3p was the only overexpressed miRNA in validation sample of patients with HNC with early stage at diagnosis (FC = 1.81, P = 0.008) and it was confirmed upregulated both in smoker early-stage cases (FC = 3.52, P = 0.024) and in nonsmoker early-stage cases (FC = 1.60, P = 0.025) compared with controls. CONCLUSIONS: We identified miR-151-3p as an early marker of HNC. This miRNA was the only upregulated in patients at early stages of the disease, independently of the smoking status. IMPACT: The prognosis for HNC is still poor. The discovery of a new diagnostic biomarker could lead to an earlier tumor discovery and therefore to an improvement in patient prognosis.
- MeSH
- cirkulující mikroRNA * MeSH
- lidé MeSH
- mikro RNA * genetika MeSH
- nádorové biomarkery genetika MeSH
- nádory hlavy a krku * diagnóza genetika MeSH
- průřezové studie MeSH
- stanovení celkové genové exprese MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.