- Salat, Jiri
- Hunady, Milan
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Svoboda, Pavel
Autor Svoboda, Pavel Laboratory of Emerging Viral Infections, Veterinary Research Institute, Brno, Czech Republic Laboratory of Arbovirology, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic Department of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic
- Strelcova, Lucie
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Strakova, Petra
Autor Strakova, Petra Laboratory of Emerging Viral Infections, Veterinary Research Institute, Brno, Czech Republic Laboratory of Arbovirology, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
- Fortova, Andrea
- Palus, Martin
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Růžek, Daniel, 1981-
Autor Autorita ORCID Laboratory of Emerging Viral Infections, Veterinary Research Institute, Brno, Czech Republic Laboratory of Arbovirology, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic. Electronic address: ruzekd@paru.cas.cz
Nursing & Allied Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health & Medicine (ProQuest) od 2002-01-01 do Před 2 měsíci
Family Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Health Management Database (ProQuest) od 2002-01-01 do Před 2 měsíci
Public Health Database (ProQuest) od 2002-01-01 do Před 2 měsíci
PubMed
37716828
DOI
10.1016/j.vaccine.2023.09.019
Knihovny.cz E-zdroje
Tick-borne encephalitis (TBE) is a severe neuroinfection of humans. Dogs are also commonly infected with tick-borne encephalitis virus (TBEV). These infections are usually asymptomatic, but sometimes show clinical signs similar to those seen in humans and can be fatal. To date, there is no TBEV vaccine available for use in dogs. To address this need, a TBEV vaccine candidate for dogs based on inactivated whole virus antigen was developed. The safety, immunogenicity, and efficacy of the vaccine candidate were tested in mice as the preclinical model and in dogs as the target organism. The vaccine was well tolerated in both species and elicited the production of specific anti-TBEV antibodies with virus neutralising activity. Vaccination of mice provided complete protection against the development of fatal TBE. Immunisation of dogs prevented the development of viremia after challenge infection. Therefore, the developed vaccine candidate is promising to protect dogs from severe TBEV infections.
- MeSH
- imunizace MeSH
- klíšťová encefalitida * prevence a kontrola veterinární MeSH
- lidé MeSH
- myši MeSH
- protilátky virové MeSH
- psi MeSH
- vakcinace MeSH
- virové vakcíny * MeSH
- viry klíšťové encefalitidy * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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