Diabetes mellitus is a chronic disease affecting glucose metabolism. The pathophysiological reactions underpinning the disease can lead to the development of late diabetes complications. The gut microbiota plays important roles in weight regulation and the maintenance of a healthy digestive system. Obesity, diabetes mellitus, diabetic retinopathy, diabetic nephropathy and diabetic neuropathy are all associated with a microbial imbalance in the gut. Modern technical equipment and advanced diagnostic procedures, including xmolecular methods, are commonly used to detect both quantitative and qualitative changes in the gut microbiota. This review summarises collective knowledge on the role of the gut microbiota in both types of diabetes mellitus and their late complications, with a particular focus on diabetic foot syndrome.
- MeSH
- diabetes mellitus * MeSH
- diabetická noha * MeSH
- diabetická retinopatie * MeSH
- diabetické nefropatie * etiologie MeSH
- lidé MeSH
- obezita MeSH
- střevní mikroflóra * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Autologní buněčná terapie je už řadu let využívána u pacientů s chronickou končetinu ohrožující ischemií. Byly publikovány četné studie a metaanalýzy, které posuzovaly benefity terapie a představily i její nové možnosti. Kromě standardně využívaných zdrojů kmenových buněk (kostní dřeně a periferní krve) se otevírají nové možnosti využití jiných alternativ - různých typů tkání. Stále však přetrvává otázka porovnání účinků jednotlivých typů buněk a jejich aplikace. Velmi zajímavé jsou i možnosti kombinované terapie hyperbarickou oxygenoterapií společně s buněčnou terapií. Dle zkušenosti našeho pracoviště je autologní buněčná terapie efektivní metoda s nízkým počtem nežádoucích událostí.
Autologous cell therapy has been used in patients with chronic limb-threatening ischemia for many years. Numerous studies and meta-analyses assessed benefits of cell therapy and also presented its new possibilities. In addition to the standard sources of stem cells, like bone marrow and peripheral blood, new possibilities of using various types of tissues were considered. There is still question about a comparison of the effect among different types of cells and their administration. The possibility of combined therapy consisting of hyperbaric oxygen therapy and stem cell therapy is also an interesting approach. According to the experience from our centre, autologous cell therapy is an effective method with low rate of adverse events.
- MeSH
- amputace MeSH
- angioplastika metody MeSH
- autologní transplantace metody MeSH
- chronická kritická ischemie končetin diagnóza terapie MeSH
- diabetes mellitus 2. typu MeSH
- diabetická noha * diagnóza prevence a kontrola terapie MeSH
- hyperbarická oxygenace metody MeSH
- lidé MeSH
- transplantace kmenových buněk metody škodlivé účinky MeSH
- Check Tag
- lidé MeSH
Chronic venous disease (CVD) is a vascular disorder in which blood return is severely compromised and CVD is usually characterized by venous hypertension. Along with obesity and diabetes mellitus, CVD is one of the most common civilization diseases. In general, the estimated prevalence of CVD ranges from 60-80 %. Early diagnosis and adequate treatment are important for preventing progression to more severe stages of the disease like venous leg ulcers. Clinical manifestations of CVD in initial stages of the disease are often asymptomatic. However, as CVD progresses, symptoms begin to develop. Treatment of CVD could be divided into conservative and surgical. Conservative therapy consists of compression, pharmacological treatment and lifestyle change. In cases where conservative therapy is ineffective, surgical or endovascular treatment may be required. The intersections between diabetes mellitus (DM) and CVD are not to be underestimated. CVD and DM have often the same risk factors. Symptoms of CVD can be modified by late complications of DM, but the incidence of different CVD degrees seems to be the same as in diabetics as in non-diabetics population. We are particularly concerned in diabetics about worse compliance with treatment due to their often-poorer adherence to treatment of DM and lifestyle changes. Moreover, there exist a higher risk of CVD and peripheral arterial disease in diabetics patients. Patients with CVD should always be inspected for the presence of DM, considering its presence can have a bearing on CVD symptoms, diagnostic procedures, and therapeutic strategies.
- MeSH
- chronická nemoc MeSH
- diabetes mellitus * diagnóza epidemiologie terapie MeSH
- kardiovaskulární nemoci * diagnóza epidemiologie terapie MeSH
- lidé MeSH
- nemoci cév * MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
