BACKGROUND: To prevent infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS-PB), some studies have investigated the efficacy of rectal disinfection using povidone-iodine (PI) and antibiotic prophylaxis (AP). OBJECTIVE: To summarize available data and compare the efficacy of rectal disinfection using PI with non-PI methods prior to TRUS-PB. EVIDENCE ACQUISITION: Three databases were queried through November 2023 for randomized controlled trials (RCTs) analyzing patients who underwent TRUS-PB. We compared the effectiveness of rectal disinfection between PI groups and non-PI groups with or without AP. The primary outcomes of interest were the rates of overall infectious complications, fever, and sepsis. Subgroups analyses were conducted to assess the differential outcomes in patients using fluoroquinolone groups compared to those using other antibiotics groups. EVIDENCE SYNTHESIS: We included ten RCTs in the meta-analyses. The overall rates of infectious complications were significantly lower when rectal disinfection with PI was performed (RR 0.56, 95% CI 0.42-0.74, p < 0.001). Compared to AP monotherapy, the combination of AP and PI was associated with significantly lower risk of infectious complications (RR 0.54, 95% CI 0.40-0.73, p < 0.001) and fever (RR 0.47, 95% CI 0.30-0.75, p = 0.001), but not with sepsis (RR 0.49, 95% CI 0.23-1.04, p = 0.06). The use of fluoroquinolone antibiotics was associated with a lower risk of infectious complications and fever compared to non-FQ antibiotics. CONCLUSION: Rectal disinfection with PI significantly reduces the rates of infectious complications and fever in patients undergoing TRUS-PB. However, this approach does not show a significant impact on reducing the rate of sepsis following the procedure.
- MeSH
- antibiotická profylaxe metody MeSH
- antiinfekční látky lokální * terapeutické užití aplikace a dávkování MeSH
- dezinfekce metody MeSH
- jodovaný povidon * terapeutické užití aplikace a dávkování MeSH
- lidé MeSH
- nádory prostaty patologie MeSH
- prostata * patologie MeSH
- rektum * MeSH
- ultrazvukem navigovaná biopsie * škodlivé účinky metody MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- systematický přehled MeSH
- MeSH
- antiinfekční látky chemie klasifikace terapeutické užití MeSH
- antisepse * MeSH
- asepse * MeSH
- dezinfekce klasifikace metody MeSH
- hygiena rukou metody MeSH
- lidé MeSH
- sterilizace klasifikace metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- deratizace MeSH
- dezinfekce * MeSH
- dezinsekce MeSH
- kongresy jako téma MeSH
- Publikační typ
- zprávy MeSH
- MeSH
- dezinfekce MeSH
- dezinficiencia * analýza MeSH
- dezinsekce MeSH
- Publikační typ
- zprávy MeSH
- MeSH
- dezinfekce * metody MeSH
- dezinficiencia MeSH
- lidé MeSH
- ordinace MeSH
- praktické lékařství MeSH
- Check Tag
- lidé MeSH
- MeSH
- asepse metody MeSH
- dezinfekce * metody MeSH
- endodoncie MeSH
- kavita zubní dřeně MeSH
- kontaminace zdravotnického vybavení * MeSH
- lidé MeSH
- sterilizace metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Microbial biofilm is a major source of problems and microbial contamination across the industrial production, for example in pharmacy, agriculture orfood industry, but also in healthcare. One of the possible solutions to this problem is the inhibition of its formation or eradication of the already formed biofilm. There are many ways to achieve this goal. This review article focuses on the use of chemical disinfectants, antibiotics or biologically active natural substances.
