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Autor
Abel, Laurent 1 Aiuti, Alessandro 1 AlKhater, Suzan 1 Amador-Borrero, Blanca 1 Anaya, Juan-Manuel 1 Anderson, Mark S 1 Andreakos, Evangelos 1 Anglicheau, Dany 1 Arias, Andrés Augusto 1 Arrestier, Romain 1 Baris-Feldman, Hagit 1 Barreiros, Lucila A 1 Bastard, Paul 1 Belot, Alexandre 1 Biggs, Catherine M 1 Bilguvar, Kaya 1 Biondi, Andrea 1 Bizien, Lucy 1 Boisson, Bertrand 1 Bondarenko, Anastasiia 1
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Organizace
3C-Dijon Study 1 Amsterdam UMC Covid-19 Biobank Invest... 1 CONSTANCES cohort 1 COVID Clinicians 1 COVID Human Genetic Effort 1 COVID-STORM Clinicians 1 CP-COVID-19 Group 1 Cerba Health-Care 1 CoV-Contact Cohort 1 Danish Blood Donor Study 1 Danish CHGE 1 Etablissement Français du Sang Study ... 1 French COVID Cohort Study Group 1 HGID Lab 1 Imagine COVID-Group 1 Milieu Intérieur Consortium 1 NH-COVAIR Study Group 1 NIAID Immune Response to COVID Group 1 St. James's Hospital, SARS CoV2 Inter... 1
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Pracoviště
ADMA Biologics Inc Ramsey NJ 07446 1 Aix Marseille University School of Me... 1 Allergy and Clinical Immunology Unit ... 1 CHemato oncology Research Laboratory ... 1 Catalan Institution of Research and A... 1 Center for Autoimmune Disease Researc... 1 Center for Autoimmune Disease Researc... 1 Centre Hospitalier Universitaire de L... 1 Centre International de Recherche en ... 1 Centre for Biomedical Research on Rar... 1 Centro de Investigación Biomédica en ... 1 Cerba HealthCare 92130 Issy les Mouli... 1 Clinical Immunology Unit Department o... 1 Cohorte Constances Groupe Hospitalier... 1 College of Medicine Imam Abdulrahman ... 1 Consorcio Centro de Investigación Bio... 1 Department of Age Related Healthcare ... 1 Department of Biomedicine Aarhus Univ... 1 Department of Biosciences and Nutriti... 1 Department of Children's Diseases and... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
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Autor
Abel, Laurent 1 Aiuti, Alessandro 1 AlKhater, Suzan 1 Amador-Borrero, Blanca 1 Anaya, Juan-Manuel 1 Anderson, Mark S 1 Andreakos, Evangelos 1 Anglicheau, Dany 1 Arias, Andrés Augusto 1 Arrestier, Romain 1 Baris-Feldman, Hagit 1 Barreiros, Lucila A 1 Bastard, Paul 1 Belot, Alexandre 1 Biggs, Catherine M 1 Bilguvar, Kaya 1 Biondi, Andrea 1 Bizien, Lucy 1 Boisson, Bertrand 1 Bondarenko, Anastasiia 1
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Organizace
3C-Dijon Study 1 Amsterdam UMC Covid-19 Biobank Invest... 1 CONSTANCES cohort 1 COVID Clinicians 1 COVID Human Genetic Effort 1 COVID-STORM Clinicians 1 CP-COVID-19 Group 1 Cerba Health-Care 1 CoV-Contact Cohort 1 Danish Blood Donor Study 1 Danish CHGE 1 Etablissement Français du Sang Study ... 1 French COVID Cohort Study Group 1 HGID Lab 1 Imagine COVID-Group 1 Milieu Intérieur Consortium 1 NH-COVAIR Study Group 1 NIAID Immune Response to COVID Group 1 St. James's Hospital, SARS CoV2 Inter... 1
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Pracoviště
ADMA Biologics Inc Ramsey NJ 07446 1 Aix Marseille University School of Me... 1 Allergy and Clinical Immunology Unit ... 1 CHemato oncology Research Laboratory ... 1 Catalan Institution of Research and A... 1 Center for Autoimmune Disease Researc... 1 Center for Autoimmune Disease Researc... 1 Centre Hospitalier Universitaire de L... 1 Centre International de Recherche en ... 1 Centre for Biomedical Research on Rar... 1 Centro de Investigación Biomédica en ... 1 Cerba HealthCare 92130 Issy les Mouli... 1 Clinical Immunology Unit Department o... 1 Cohorte Constances Groupe Hospitalier... 1 College of Medicine Imam Abdulrahman ... 1 Consorcio Centro de Investigación Bio... 1 Department of Age Related Healthcare ... 1 Department of Biomedicine Aarhus Univ... 1 Department of Biosciences and Nutriti... 1 Department of Children's Diseases and... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Manry, Jérémy
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Bastard, Paul
Autor Bastard, Paul ORCID Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France Imagine Institute, University of Paris, 75015 Paris, France St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065
- Gervais, Adrian
- Le Voyer, Tom
- Rosain, Jérémie
- Philippot, Quentin
- Michailidis, Eleftherios
- Hoffmann, Hans-Heinrich
- Eto, Shohei
- Garcia-Prat, Marina
NLK
Free Medical Journals
od 1915 do Před 6 měsíci
Freely Accessible Science Journals
od 1915 do Před 6 měsíci
PubMed Central
od 1915 do Před 6 měsíci
Europe PubMed Central
od 1915 do Před 6 měsíci
Open Access Digital Library
od 1915-01-01
Open Access Digital Library
od 1915-01-15
PubMed
35576468
DOI
10.1073/pnas.2200413119
Knihovny.cz E-zdroje
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
- MeSH
- autoimunita * MeSH
- autoprotilátky * krev MeSH
- COVID-19 * imunologie mortalita MeSH
- dospělí MeSH
- interferon typ I * imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- neutralizující protilátky * krev MeSH
- riziko MeSH
- SARS-CoV-2 * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
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