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Autor
Bjørge, Line 1 Bolt, Ineke 1 Cibula, David 1 Colombo, Nicoletta 1 Dillner, Joakim 1 Dudbridge, Frank 1 Evans, Iona 1 Harbeck, Nadia 1 Joly, Yann 1 Jones, Allison 1 Knoppers, Bartha M 1 Pashayan, Nora 1 Rebitschek, Felix G 1 Reisel, Daniel 1 Siebert, Uwe 1 Sroczynski, Gaby 1 Steyerberg, Ewout W 1 Sundström, Karin 1 Tasse, Anne-Marie 1 Teschendorff, Andrew E 1
- Organizace
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Pracoviště
Breast Center Department of Gynaecolo... 1 Center for Medical Decision Sciences ... 1 Center for Medical Decision Sciences ... 1 Centre of Genomics and Policy McGill ... 1 Department of Applied Health Research... 1 Department of Laboratory Medicine Kar... 1 Department of Medical Ethics and Phil... 1 Department of Non communicable Diseas... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Women's Cancer Institut... 1 European Institute of Oncology and Un... 1 Institute of Public Health Medical De... 1 Institute of Public Health Medical De... 1 Max Planck Institute for Human Develo... 1 Max Planck Institute for Human Develo... 1 Public Population Project in Genomics... 1
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Autor
Bjørge, Line 1 Bolt, Ineke 1 Cibula, David 1 Colombo, Nicoletta 1 Dillner, Joakim 1 Dudbridge, Frank 1 Evans, Iona 1 Harbeck, Nadia 1 Joly, Yann 1 Jones, Allison 1 Knoppers, Bartha M 1 Pashayan, Nora 1 Rebitschek, Felix G 1 Reisel, Daniel 1 Siebert, Uwe 1 Sroczynski, Gaby 1 Steyerberg, Ewout W 1 Sundström, Karin 1 Tasse, Anne-Marie 1 Teschendorff, Andrew E 1
- Organizace
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Pracoviště
Breast Center Department of Gynaecolo... 1 Center for Medical Decision Sciences ... 1 Center for Medical Decision Sciences ... 1 Centre of Genomics and Policy McGill ... 1 Department of Applied Health Research... 1 Department of Laboratory Medicine Kar... 1 Department of Medical Ethics and Phil... 1 Department of Non communicable Diseas... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Women's Cancer Institut... 1 European Institute of Oncology and Un... 1 Institute of Public Health Medical De... 1 Institute of Public Health Medical De... 1 Max Planck Institute for Human Develo... 1 Max Planck Institute for Human Develo... 1 Public Population Project in Genomics... 1
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Nursing & Allied Health Database (ProQuest) od 2009-04-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2009-04-01 do Před 1 rokem
PubMed
29485132
DOI
10.1038/nrclinonc.2018.30
Knihovny.cz E-zdroje
The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary prevention strategies are urgently required. The ideal risk-predictive test should: integrate the effects of both genetic and nongenetic factors and aim to capture these effects using an approach that is both biologically stable and technically reproducible; derive a score from easily accessible biological samples that acts as a surrogate for the organ in question; and enable the effectiveness of risk-reducing measures to be monitored. Substantial evidence has accumulated suggesting that the epigenome and, in particular, DNA methylation-based tests meet all of these requirements. However, the development and implementation of DNA methylation-based risk-prediction tests poses considerable challenges. In particular, the cell type specificity of DNA methylation and the extensive cellular heterogeneity of the easily accessible surrogate cells that might contain information relevant to less accessible tissues necessitates the use of novel methods in order to account for these confounding issues. Furthermore, the engagement of the scientific community with health-care professionals, policymakers and the public is required in order to identify and address the organizational, ethical, legal, social and economic challenges associated with the routine use of epigenetic testing.
- MeSH
- epigenomika trendy MeSH
- genom lidský genetika MeSH
- hodnocení rizik * MeSH
- lidé MeSH
- metylace DNA genetika MeSH
- nádory epidemiologie genetika MeSH
- rizikové faktory MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
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