Small fish species, such as zebrafish and medaka, are increasingly gaining popularity in basic research and disease modeling as a useful alternative to rodent model organisms. However, the tracking options for fish within a facility are rather limited. In this study, we present an aquatic species tracking database, Zebrabase, developed in our zebrafish research and breeding facility that represents a practical and scalable solution and an intuitive platform for scientists, fish managers, and caretakers, in both small and large facilities. Zebrabase is a scalable, cross-platform fish tracking database developed especially for fish research facilities. Nevertheless, this platform can be easily adapted for a wide variety of aquatic model organisms housed in tanks. It provides sophisticated tracking, reporting, and management functions that help keep animal-related records well organized, including a QR code functionality for tank labeling. The implementation of various user roles ensures a functional hierarchy and customized access to specific functions and data. In addition, Zebrabase makes it easy to personalize rooms and racks, and its advanced statistics and reporting options make it an excellent tool for creating periodic reports of animal usage and productivity. Communication between the facility and the researchers can be streamlined by the database functions. Finally, Zebrabase also features an interactive breeding history and a smart interface with advanced visualizations and intuitive color coding that accelerate the processes.

• MeSH
• automatizované zpracování dat MeSH
• chov zvířat metody   organizace a řízení   MeSH
• dánio pruhované * MeSH
• databáze faktografické MeSH
• laboratorní zvířata * MeSH
• monitorování životního prostředí MeSH
• software * MeSH
• vodní hospodářství metody   organizace a řízení   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Recently, the indiscriminate use of antibiotics in the aquaculture sector has raised public concern because of possible toxic effects, development of bacterial resistance, and accumulation of residues in individual tissues. Even if several countries have developed regulations about their use, it is clear that long-term growth of the aquaculture industry requires both ecologically sound practices and sustainable resource management. Alternative strategies for better management of antibiotic administration are of primary interest to improve absorption rates and, as a consequence, to reduce their release into the aquatic environment. The present study investigates, for the first time to our knowledge, a new methodology for oxytetracycline (OTC) administration through the use of iron oxide nanoparticles (NPs) (made of maghemite γ-Fe2O3) in zebrafish (Danio rerio). Fish were divided into 4 experimental groups: control; group A exposed to 4 mg/L OTC (through water); group B exposed to the 100 mg/L SAMNs@OTC complex (equivalent to 4 mg/L OTC), and group C exposed to bare NPs. No detoxification processes or anatomical alterations were observed in fish exposed to bare NPs. Exposure of fish to the SAMNs@OTC complex resulted in a 10 times higher OTC accumulation with respect to using water exposure. This new OTC administration method seems much more efficient with respect to the traditional way of exposure and has the potentiality to reduce antibiotic utilization and possible environmental impacts. However, the dynamics related to OTC release from the SAMNs@OTC complex are still not clear and need further investigations.

• MeSH
• antibakteriální látky aplikace a dávkování   MeSH
• dánio pruhované * MeSH
• kovové nanočástice chemie   MeSH
• lékové transportní systémy metody   normy   MeSH
• oxytetracyklin aplikace a dávkování   MeSH
• rybářství MeSH
• železité sloučeniny chemie   MeSH
• zvířata MeSH
• Check Tag
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH