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Autor
Brandes, Axel 1 Breithardt, Günter 1 Camm, A John 1 Crijns, Harry J G M 1 Eckardt, Lars 1 Elvan, Arif 1 Goette, Andreas 1 Haegeli, Laurent M 1 Heidbuchel, Hein 1 Kautzner, Josef 1 Kirchhof, Paulus 1 Kuck, Karl-Heinz 1 Metzner, Andreas 1 Mont, Luis 1 Ng, G Andre 1 Suling, Anna 1 Szumowski, Lukasz 1 Themistoclakis, Sakis 1 Vardas, Panos 1 Wegscheider, Karl 1
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Pracoviště
Arrhythmia Center of the National Ins... 1 Atrial Fibrillation Network Münster G... 1 Cardiology Clinical Academic Group Mo... 1 Cardiovascular Sciences University of... 1 Centro Investigación Biomedica en Red... 1 Department of Cardiology 2 University... 1 Department of Cardiology Asklepios Kl... 1 Department of Cardiology Maastricht U... 1 Department of Cardiology Odense Unive... 1 Department of Cardiology Ospedale del... 1 Department of Cardiology University H... 1 Department of Cardiovascular Sciences... 1 Department of Clinical Research Unive... 1 Division of Cardiology Medical Univer... 1 German Center of Cardiovascular Resea... 1 Heart Sector Hygeia Hospitals Group A... 1 Institute for Clinical and Experiment... 1 Institute of Medical Biometry and Epi... 1 Isala Hospital and Diagram Research Z... 1 LANS Cardio Hamburg Germany 1
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Země - grant
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Grantová agentura
AFNET, DZHK 1 AFNET, DZHK, EHRA, DHS, Abbott Labora... 1 Abbott Laboratories 1 British Heart Foundation 1 ClinicalTrials.gov 1 EAST-AFNET 4 ISRCTN 1 EHRA, DHS 1 European Union BigData@Heart 1 German Centre for Cardiovascular Rese... 1 German Ministry of Education and Rese... 1 Leducq Foundation 1 Sanofi 1
- Nejvíce citované
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Autor
Brandes, Axel 1 Breithardt, Günter 1 Camm, A John 1 Crijns, Harry J G M 1 Eckardt, Lars 1 Elvan, Arif 1 Goette, Andreas 1 Haegeli, Laurent M 1 Heidbuchel, Hein 1 Kautzner, Josef 1 Kirchhof, Paulus 1 Kuck, Karl-Heinz 1 Metzner, Andreas 1 Mont, Luis 1 Ng, G Andre 1 Suling, Anna 1 Szumowski, Lukasz 1 Themistoclakis, Sakis 1 Vardas, Panos 1 Wegscheider, Karl 1
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Pracoviště
Arrhythmia Center of the National Ins... 1 Atrial Fibrillation Network Münster G... 1 Cardiology Clinical Academic Group Mo... 1 Cardiovascular Sciences University of... 1 Centro Investigación Biomedica en Red... 1 Department of Cardiology 2 University... 1 Department of Cardiology Asklepios Kl... 1 Department of Cardiology Maastricht U... 1 Department of Cardiology Odense Unive... 1 Department of Cardiology Ospedale del... 1 Department of Cardiology University H... 1 Department of Cardiovascular Sciences... 1 Department of Clinical Research Unive... 1 Division of Cardiology Medical Univer... 1 German Center of Cardiovascular Resea... 1 Heart Sector Hygeia Hospitals Group A... 1 Institute for Clinical and Experiment... 1 Institute of Medical Biometry and Epi... 1 Isala Hospital and Diagram Research Z... 1 LANS Cardio Hamburg Germany 1
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Země - grant
-
Grantová agentura
AFNET, DZHK 1 AFNET, DZHK, EHRA, DHS, Abbott Labora... 1 Abbott Laboratories 1 British Heart Foundation 1 ClinicalTrials.gov 1 EAST-AFNET 4 ISRCTN 1 EHRA, DHS 1 European Union BigData@Heart 1 German Centre for Cardiovascular Rese... 1 German Ministry of Education and Rese... 1 Leducq Foundation 1 Sanofi 1
- Nejvíce citované
PubMed
34473249
PubMed Central
PMC8982435
DOI
10.1093/europace/euab200
PII: 6362667
Knihovny.cz E-zdroje
AIMS: Treatment patterns were compared between randomized groups in EAST-AFNET 4 to assess whether differences in anticoagulation, therapy of concomitant diseases, or intensity of care can explain the clinical benefit achieved with early rhythm control in EAST-AFNET 4. METHODS AND RESULTS: Cardiovascular treatment patterns and number of visits were compared between randomized groups in EAST-AFNET 4. Oral anticoagulation was used in >90% of patients during follow-up without differences between randomized groups. There were no differences in treatment of concomitant conditions between groups. The type of rhythm control varied by country and centre. Over time, antiarrhythmic drugs were given to 1171/1395 (84%) patients in early therapy, and to 202/1394 (14%) in usual care. Atrial fibrillation (AF) ablation was performed in 340/1395 (24%) patients randomized to early therapy, and in 168/1394 (12%) patients randomized to usual care. 97% of rhythm control therapies were within class I and class III recommendations of AF guidelines. Patients randomized to early therapy transmitted 297 166 telemetric electrocardiograms (ECGs) to a core lab. In total, 97 978 abnormal ECGs were sent to study sites. The resulting difference between study visits was low (0.06 visits/patient/year), with slightly more visits in early therapy (usual care 0.39 visits/patient/year; early rhythm control 0.45 visits/patient/year, P < 0.001), mainly due to visits for symptomatic AF recurrences or recurrent AF on telemetric ECGs. CONCLUSION: The clinical benefit of early, systematic rhythm control therapy was achieved using variable treatment patterns of antiarrhythmic drugs and AF ablation, applied within guideline recommendations.
- Klíčová slova
- Ablation, Antiarrhythmic drugs, Anticoagulation, Atrial fibrillation, Cardiovascular death, Heart failure, Rhythm control therapy, Stroke,
- MeSH
- antiarytmika terapeutické užití MeSH
- antikoagulancia terapeutické užití MeSH
- cévní mozková příhoda * terapie MeSH
- fibrilace síní * diagnóza farmakoterapie MeSH
- katetrizační ablace * škodlivé účinky metody MeSH
- lidé MeSH
- sekundární prevence MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- antiarytmika MeSH
- antikoagulancia MeSH
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