The paper evaluates the influence of three surfactants (carbetopendecinium halogenides) on the liberation of the drug chlorhexidine dihydrochloride (CHX) in 0.1% (w/w) from the dosage form-gel and also the flow properties of gels. The following tensides were evaluated: carbetopendecinium bromide (SB), carbetopendecinium chloride (SC), and carbetopendecinium iodide (SI). The tenside concentration was set under the critical micelle concentration. The biopolymer - chitosan (CHIT) in 2.5% (w/w) concentration was used as a gel creating substance. Based on the flow properties of the studied gels, it was found that the employed tensides exhibited no influence on the character of the system. The gels exhibited the character of plastic systems with time-independent flow. The drug liberation was evaluated at the temperatures of 20, 30 and 40 °C. Between the types of the tensides, the statistically significant differences (P < 0.05) were found as to the amount of the liberated CHX, which was reflected by the increased amount of the liberated drug. Based on the obtained results, it can be concluded that the most suitable was the SI tenside. From the gel with this tenside the greatest amount of CHX was liberated, which had the highest value of the liberation rate constant.
- MeSH
- antiinfekční látky lokální aplikace a dávkování chemie farmakologie MeSH
- chitosan chemie MeSH
- chlorhexidin aplikace a dávkování chemie farmakologie MeSH
- gely MeSH
- kvartérní amoniové sloučeniny chemie MeSH
- micely MeSH
- povrchově aktivní látky chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiinfekční látky lokální MeSH
- chitosan MeSH
- chlorhexidin MeSH
- gely MeSH
- kvartérní amoniové sloučeniny MeSH
- micely MeSH
- povrchově aktivní látky MeSH
The trend during the past years is to prefer natural drugs to synthetically prepared medicines. Due to its important antiphlogistic, antiseptic and antihidrotic effects, Salvia officinalis L. has a wide use in medicine, pharmacy and cosmetics in various dosage forms. The aim of this research was the formulation of Salvia officinalis L. in the form of a tincture to hydrogels. Gels were parallelly prepared on the basis of the natural polymer chitosan and the synthetic polymer Carbopol 940. The evaluation was focused on the influence of the anionic polymer and the cationic polymer in different concentrations on hydrogel flow properties. Glycerol functioning as a humectant was used in various percentage ratios. On the basis of the determination of rheological parameters and flow curves lapses the most suitable hydrogel from the application point of view was selected.
- MeSH
- farmaceutická chemie MeSH
- fytoterapie * MeSH
- hydrogely MeSH
- lidé MeSH
- rostlinné přípravky * MeSH
- šalvěj lékařská * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- hydrogely MeSH
- rostlinné přípravky * MeSH
The paper evaluates the liberation of alaptide from gels through various types of permeable membranes. The gels were prepared on the basis of three different polymers (3% chitosan; 2.5% hydroxypropyl cellulose; 3% hydroxyethyl cellulose) in different concentrations with additions of humectants (5 %; 15% propylene glycol and 10% glycerol) and the preserving agent, 0.3% Sepicide HBR with 1% alaptide, and finally without the drug. The permeation of the drug from gels into the acceptor solution was evaluated with the use of the following membranes: the hydrophilic membrane from Chemosvit, the chicken skin, the stripped snakeskin, and the wall of the small intestine. The measurements showed that the highest percentage of the drug penetrated through the small intestine, a smaller percentage through the chicken skin, and the smallest amount through the snakeskin. Rheological properties of the prepared hydrogels were evaluated as well. The pseudoplastic flow was only confirmed for the hydrogel prepared on the basis of hydroxypropyl cellulose. An utterly opposite situation was with the hydrogels prepared on the basis of chitosan and hydroxyethyl cellulose. They showed a significant thixotropic character and the degree of thixotropy increased with time. Based on the results of the pH measurement, the samples prepared on the basis of chitosan and hydroxypropyl cellulose have been shown to be inconvenient because they reached a lower pH and had a potential of causing skin irritation. The hydroxyethyl cellulose hydrogel matched the physiological values of skin pH even after 14 days since its preparation.
- MeSH
- cyklické peptidy farmakokinetika MeSH
- hydrogely * MeSH
- membrány umělé * MeSH
- neuropeptidy farmakokinetika MeSH
- permeabilita * MeSH
- reologie MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Názvy látek
- cyclo(alanine-(1-amino-1-cyclopentane)carbonyl) MeSH Prohlížeč
- cyklické peptidy MeSH
- hydrogely * MeSH
- membrány umělé * MeSH
- neuropeptidy MeSH
The objective of this article is to describe the formulation and evaluation of dermal semisolid drugs--carbopol hydrogels containing the solution of Bukofit, zinc chloride and the local anaesthetic lidocaine. The hydrogels were evaluated after 2, 7, 14 and 28 days after their preparation and stored at the temperature of 5 degrees C +/- 0.2 degrees C. All prepared hydrogels were found to be stable with respect to pH values and rheological parameters. It follows from the found rheological parameters and flow curves that all evaluated hydrogels belong to non-Newtonian thixotropic systems. The extensometric analyses revealed increased deformation values, indicating that the gels can be easily spread out over the mucous membrane which results in the increased ability of the drug to diffuse into it. Based on the results obtained, it can be concluded that the prepared hydrogels have appropriate technological parameters and therefore in the future they may become potential drugs for the treatment of various inflammations in the oral cavity.
- MeSH
- akrylové pryskyřice MeSH
- anestetika lokální * MeSH
- chloridy MeSH
- farmaceutická chemie * MeSH
- hydrogely MeSH
- lidokain * MeSH
- nosiče léků * MeSH
- polyvinyly * MeSH
- reologie MeSH
- sliznice metabolismus MeSH
- sloučeniny zinku MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- akrylové pryskyřice MeSH
- anestetika lokální * MeSH
- carboxypolymethylene MeSH Prohlížeč
- chloridy MeSH
- hydrogely MeSH
- lidokain * MeSH
- nosiče léků * MeSH
- polyvinyly * MeSH
- sloučeniny zinku MeSH
- zinc chloride MeSH Prohlížeč
