The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-α, MIP-1β, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into three groups. Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0). Concentrations of BAL nitrites/nitrates from groups II and III increased during the first hour of mechanical ventilation (P = .03 and .02, respectively). The highest expression of iNOS was observed during the first hour in groups II and III. IL-8 concentration increased significantly in groups II and III. Production of TNF-α increased significantly in group III during the second and third hour (P = .01). Concentration of MIP-1β was significantly increased in groups II and III after the first hour (P = .012 and P = .008, respectively).

• MeSH
• akutní poškození plic etiologie   metabolismus   MeSH
• bronchoalveolární lavážní tekutina chemie   cytologie   MeSH
• chemokin CCL4 metabolismus   MeSH
• cytokiny metabolismus   MeSH
• dechový objem MeSH
• dusičnany metabolismus   MeSH
• dusitany metabolismus   MeSH
• interleukin-8 metabolismus   MeSH
• plíce metabolismus   patologie   patofyziologie   MeSH
• plicní alveoly metabolismus   patologie   MeSH
• poddajnost plic fyziologie   MeSH
• prasata MeSH
• synthasa oxidu dusnatého, typ II metabolismus   MeSH
• TNF-alfa metabolismus   MeSH
• umělé dýchání škodlivé účinky   MeSH
• ventilace umělá s výdechovým přetlakem přístrojové vybavení   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• chemokin CCL4 MeSH
• cytokiny MeSH
• dusičnany MeSH
• dusitany MeSH
• interleukin-8 MeSH
• synthasa oxidu dusnatého, typ II MeSH
• TNF-alfa MeSH

Lung volume, indices of lung elasticity and airway patency were measured in 74 patients, 9-21 yr old (15.0 +/- 2.5 yr) with atrial septal defect (secundum type) from 2-11 (5.1 +/- 2.5) yr after successful surgical correction. Clinical condition in all patients was classified as excellent. Heart surgery was performed at the age of 4-14.8 (9.9 +/- 3.0) yr. Lung function abnormalities were found in 35 (47.3%) patients. Lung recoil pressure was significantly increased in 24 (32.4%) patients. The mean value of lung recoil pressure at 100% of total lung capacity reached 123 +/- 31% of the predicted value (P < 0.0001). Specific static compliance was within normal limits. Specific airway conductance was significantly reduced in 13 (17.6%) patients. Maximum expiratory flow at 25% of vital capacity was significantly reduced in 4 (5.4%) patients. Static lung volumes did not differ from reference values. Since various abnormalities of lung function tests (most frequently the tests suggested increased lung stiffness and obstruction of larger airways) were revealed in almost half of the studied children and adolescents after successful surgery for atrial septal defect, we propose to carry out lung function tests routinely as another criterion of health conditions in these patients.

• MeSH
• cévní rezistence fyziologie   MeSH
• defekty septa síní patofyziologie   chirurgie   MeSH
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• měření objemu plic * MeSH
• mladiství MeSH
• plicní oběh fyziologie   MeSH
• plicní tlak v zaklínění fyziologie   MeSH
• poddajnost plic fyziologie   MeSH
• pooperační komplikace patofyziologie   MeSH
• rezistence dýchacích cest fyziologie   MeSH
• umělé dýchání MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH