Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.

• Klíčová slova
• burn, cell interaction, pathological scar, skin, stem cell, wound healing,
• MeSH
• epitelové buňky metabolismus   patologie   MeSH
• extracelulární matrix metabolismus   patologie   MeSH
• fibroblasty metabolismus   patologie   MeSH
• hojení ran genetika   MeSH
• jizva hypertrofická genetika   imunologie   patologie   MeSH
• lidé MeSH
• popálení genetika   patologie   MeSH
• proliferace buněk genetika   MeSH
• zánět genetika   patologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH