Nejvíce citovaný článek - PubMed ID 11298451
Fillets from marine fish species contain n-3 polyunsaturated fatty acids (PUFAs) in the form of phospholipids (PLs). To investigate the importance of PL-bound n-3 PUFAs in mediating the anti-obesogenic effect of lean seafood, we compared the anti-obesogenic properties of fillets from cod with fillets from pangasius, a fresh water fish with a very low content of PL-bound n-3 PUFAs. We prepared high-fat/high-protein diets using chicken, cod and pangasius as the protein sources, and fed male C57BL/6J mice these diets for 12 weeks. Mice fed the diet containing cod gained less adipose tissue mass and had smaller white adipocytes than mice fed the chicken-containing diet, whereas mice fed the pangasius-containing diet were in between mice fed the chicken-containing diet and mice fed the cod-containing diet. Of note, mice fed the pangasius-containing diet exhibited reduced glucose tolerance compared to mice fed the cod-containing diet. Although the sum of marine n-3 PUFAs comprised less than 2% of the total fatty acids in the cod-containing diet, this was sufficient to significantly increase the levels of eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) in mouse tissues and enhance production of n-3 PUFA-derived lipid mediators as compared with mice fed pangasius or chicken.
- Klíčová slova
- DHA, EPA, endocannabinoids, marine protein source, n-3 PUFA, nutrition, obesity and mice, phospholipids, seafood,
- MeSH
- dieta s vysokým obsahem proteinů metody MeSH
- dieta s vysokým obsahem tuků metody MeSH
- drůbeží výrobky MeSH
- Gadus morhua * MeSH
- kyselina eikosapentaenová metabolismus MeSH
- kyseliny dokosahexaenové metabolismus MeSH
- kyseliny mastné omega-3 analýza MeSH
- látky proti obezitě analýza MeSH
- mastné kyseliny analýza MeSH
- metabolismus lipidů MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- potrava z moře (živočišná) analýza MeSH
- sumci * MeSH
- tuková tkáň metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- kyselina eikosapentaenová MeSH
- kyseliny dokosahexaenové MeSH
- kyseliny mastné omega-3 MeSH
- látky proti obezitě MeSH
- mastné kyseliny MeSH