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Autor
Brenner, Hermann 1 Brezina, Stefanie 1 Butterbach, Katja 1 Chang-Claude, Jenny 1 Da Silva Filho, Miguel Inacio 1 Díez-Villanueva, Anna 1 Försti, Asta 1 García-Verdejo, Francisco José 1 Gsur, Andrea 1 Hemminki, Kari 1 Hoffmeister, Michael 1 Jurado, Manuel 1 Kumar, Abhishek 1 Li, Yang 1 Ludovico, Paula 1 Martin Sánchez, Vicente 1 Martínez-Bueno, Manuel 1 Moreno, Víctor 1 Netea, Mihai G 1 Sainz, Juan 1
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Pracoviště
Area of Genomic Medicine GENYO Centre for Ge... 1 Biomedical Centre Faculty of Medicine in Pil... 1 Catalan Institute of Oncology Bellvitge Biom... 1 Centre for Individualised Infection Medicine... 1 Consortium for Biomedical Research in Epidem... 1 Department for Immunology and Metabolism Lif... 1 Department of Internal Medicine and Radboud ... 1 Department of Medical Oncology Complejo Hosp... 1 Department of Medicine 1 Institute of Cancer... 1 Department of Medicine University of Granada... 1 Department of Molecular Biology of Cancer In... 1 Division of Cancer Epidemiology German Cance... 1 Division of Cancer Epidemiology German Cance... 1 Division of Clinical Epidemiology and Aging ... 1 Division of Molecular Genetic Epidemiology G... 1 Division of Pediatric Neurooncology German C... 1 Division of Preventive Oncology German Cance... 1 Faculty of Medicine and Biomedical Center in... 1 Genetic Tumour Epidemiology Group University... 1 Genomic Oncology Area GENYO Centre for Genom... 1
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
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Grantová podpora
COST Action 1 Instituto de Salud Carlos III 1 PROGRES 1 Ramalingaswami Re-Retry Faculty Fellowship 1 The Agency for Management of University and ... 1 The Austrian Research Promotion Agency (FFG)... 1 The Herzfelder'sche Familienstiftung 1 The Spanish Association Against Cancer (AECC... 1 UNCE/MED 1
- Nejvíce citované
Nejvíce citovaný článek - PubMed ID 18833585
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Sainz, Juan
Autor Sainz, Juan ORCID Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain Hematology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain Instituto de Investigación Biosanataria IBs.Granada, 18012 Granada, Spain Department of Medicine, University of Granada, 18016 Granada, Spain
- García-Verdejo, Francisco José
- Martínez-Bueno, Manuel
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Kumar, Abhishek
Autor Kumar, Abhishek ORCID Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka 560066, India Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India
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Sánchez-Maldonado, José Manuel
Autor Sánchez-Maldonado, José Manuel Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, 18016 Granada, Spain Hematology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain Instituto de Investigación Biosanataria IBs.Granada, 18012 Granada, Spain
- Díez-Villanueva, Anna
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Vodičková, Ludmila
Autor Vodičková, Ludmila Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 00 Prague, Czech Republic Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 12800 Prague, Czech Republic Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic
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Vymetálková, Veronika
Autor Autorita ORCID Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 00 Prague, Czech Republic Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, 12800 Prague, Czech Republic Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic
- Martin Sánchez, Vicente
- Da Silva Filho, Miguel Inacio
PubMed
33809172
PubMed Central
PMC7998818
DOI
10.3390/cancers13061258
PII: cancers13061258
Knihovny.cz E-zdroje
The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent European cohorts (8006 CRC cases and 7070 controls), two loci, DAPK2 (p = 2.19 × 10-5) and ATG5 (p = 6.28 × 10-4) were associated with the risk of CRC. Mechanistically, the DAPK2rs11631973G allele was associated with IL1 β levels after the stimulation of peripheral blood mononuclear cells (PBMCs) with Staphylococcus aureus (p = 0.002), CD24 + CD38 + CD27 + IgM + B cell levels in blood (p = 0.0038) and serum levels of en-RAGE (p = 0.0068). ATG5rs546456T allele was associated with TNF α and IL1 β levels after the stimulation of PBMCs with LPS (p = 0.0088 and p = 0.0076, respectively), CD14+CD16- cell levels in blood (p = 0.0068) and serum levels of CCL19 and cortisol (p = 0.0052 and p = 0.0074, respectively). Interestingly, no association with autophagy flux was observed. These results suggested an effect of the DAPK2 and ATG5 loci in the pathogenesis of CRC, likely through the modulation of host immune responses.
- Klíčová slova
- autophagy, colorectal cancer, genetic variants, susceptibility,
- Publikační typ
- časopisecké články MeSH
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