Two structurally different copper(II) complexes of the compositions [{Cu(9dhx)(H2O)3}2(µ-SO4)2] (1) and [Cu(9dhx)2(H2O)2(NO3)2]·H2O (2), involving 9-deazahypoxanthine (9dhx; 6-oxo-9-deazapurine; 9-deazahypoxanthine), have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, electrospray ionisation (ESI) mass spectrometry, thermogravimetric (TG) and differential thermal (DTA) analyses, and cyclic voltammetry. The X-ray structures of complexes 1 and [Cu(9dhx)2(H2O)2(NO3)2] (2a) revealed the distorted octahedral geometry in the vicinity of the copper(II) atoms, with the NO5 and N2O4 donor set, respectively. In the dimeric compound 1, the {Cu(9dhx)(H2O)3}2 units are bridged by sulfate groups with the Cu···Cu separation being 5.3446(2) Å. In both structures the 9dhx ligands are coordinated through the N3 atoms of the pyrimidine moieties. The SOD-like activity of complexes 1 and 2 was evaluated in vitro showing moderate effect, with the IC50 values equal to 18.20, and 53.33 μM, respectively.

• Keywords
• 6-oxo-9-deazapurine, 9-deazahypoxanthine, X-ray crystal structure, copper(II) complexes, in vitro SOD-like activity,
• MeSH
• Biocompatible Materials chemistry   metabolism   MeSH
• Electrochemical Techniques MeSH
• Spectrometry, Mass, Electrospray Ionization MeSH
• Hypoxanthines chemistry   MeSH
• Coordination Complexes chemistry   metabolism   MeSH
• Crystallography, X-Ray MeSH
• Copper chemistry   MeSH
• Molecular Conformation MeSH
• Spectroscopy, Fourier Transform Infrared MeSH
• Superoxide Dismutase metabolism   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• 9-deazahypoxanthine MeSH Browser
• Biocompatible Materials MeSH
• Hypoxanthines MeSH
• Coordination Complexes MeSH
• Copper MeSH
• Superoxide Dismutase MeSH