Due to their bioavailability, glycosylated carotenoids may have interesting biological effects. Sioxanthin, as a representative of this type of carotenoid, has been identified in marine actinomycetes of the genus Salinispora. This study evaluates, for the first time, the effect of cultivation temperature (T) and light intensity (LI) on the total cellular carotenoid content (TC), antioxidant activity (AA) and sioxanthin content (SX) of a crude extract (CE) from Salinispora tropica biomass in its vegetative state. Treatment-related differences in TC and SX values were statistically significantly and positively affected by T and LI, while AA was most significantly affected by T. In the S. tropica CE, TC correlated well (R2 = 0.823) with SX and somewhat less with AA (R2 = 0.777). A correlation between AA and SX was found to be less significant (R2 = 0.731). The most significant protective effect against oxidative stress was identified in the CE extracted from S. tropica biomass grown at the highest T and LI (CE-C), as was demonstrated using LNCaP and KYSE-30 human cell lines. The CE showed no cytotoxicity against LNCaP and KYSE-30 cell lines.

• Klíčová slova
• Salinispora tropica, antioxidant activity, sioxanthin, total cellular carotenoids,
• MeSH
• antioxidancia chemie   farmakologie   MeSH
• bifenylové sloučeniny MeSH
• biomasa MeSH
• buněčné linie účinky léků   MeSH
• karotenoidy metabolismus   farmakologie   MeSH
• komplexní směsi MeSH
• lidé MeSH
• Micromonosporaceae * MeSH
• mycelium MeSH
• oxidační stres účinky léků   MeSH
• pikráty MeSH
• světlo MeSH
• teplota MeSH
• vodní organismy MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• 1,1-diphenyl-2-picrylhydrazyl MeSH Prohlížeč
• antioxidancia MeSH
• bifenylové sloučeniny MeSH
• karotenoidy MeSH
• komplexní směsi MeSH
• pikráty MeSH
• sioxanthin MeSH Prohlížeč