INTRODUCTION: Youth mental health is a growing concern, with reports of psychiatric diagnoses becoming increasingly prevalent. Among other factors, psychiatrization may inflate the observed prevalence by interpreting experiences previously understood as adversities inherent to human life as symptoms of psychopathology. The current study explores the pathologization of behaviors typical of adolescence by asking contemporary psychiatrists to diagnose and treat a character from a novel who is considered a prototypical teenager of the 19th century: Tom Sawyer. METHODS: A one-page vignette was distributed either in sealed envelopes or via email to 57 psychiatrists who had obtained their license for independent practice between 2021 and 2023 in the Czech Republic. In total, 47 psychiatrists took part, yielding an overall response rate of 82%. The number and frequency of diagnostic conclusions, prescribed medications, and recommended interventions are reported. RESULTS: Most respondents diagnosed the boy described in the vignette with a psychiatric disorder (94%; CI = 81-98%) and recommended an intervention within the healthcare system (89%; CI =76-96%). Two thirds (62%, CI = 46-75%) recommended pharmacotherapy: antidepressants (27%), antipsychotics (22%), stimulants (13%), and anxiolytics (2%); 68% (53-80%) recommended psychotherapy. Nonmedical interventions (e.g., counseling, social services) were recommended by 49%. CONCLUSIONS: The experiences of an adolescent boy, once interpreted as normative "adventures" in the 19th century, were recognized by newly certified psychiatrists as psychiatric disorder. These findings illustrate the extent of psychiatrization over time and suggest that expert diagnoses may substantially contribute to the overinterpretation of problems of living as psychiatric disorders.

• Klíčová slova
• adolescent, cross-cultural comparison, diagnostic inflation, mental disorders, psychiatrization of society,
• Publikační typ
• časopisecké články MeSH

Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE's results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.

• Klíčová slova
• Adolescent health, Child health, Early life, Exposome, Exposure assessment,
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH