The aim of this study is to describe the ultrasonographic features of feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) before histological diagnosis and during follow-up after surgical excision and/or medical treatment. This multicentric retrospective case series study includes medical records of cats diagnosed histologically, which had an ultrasound before diagnosis and a minimum of one follow-up ultrasound at least 4 weeks after treatment. Thirty cats were included in the study. The average age was 4.9 years (IQR 3.3-9.3 years). In 25 cases, the mass affected the gastrointestinal system, most commonly the proximal duodenum (36%: 9/25). Three masses originated from the lymph nodes, and two were mesenteric. The most common clinical signs were chronic vomiting, weight loss, and anorexia/reduced appetite. In 25 of 30 (83%) FGESF gastrointestinal cases, ultrasonographically, the lesions generally presented as focal, circumferential, eccentric masses with loss of layering, heterogeneous echogenicity, and hyperechoic areas. Hyperechogenicities in the peritoneum were observed in 63% of the cases, and enlarged lymph nodes (88%) were common. On final follow-up, 55% of the patients had complete resolution of the main lesion, peritoneal changes, and lymphadenopathies ultrasonographically. The disease recurred in 11 of 30 (37%), and progression was reported in 10 of 30 (33%) cases during the follow-up. Initially, 9 of these 10 were diagnosed via nonexcisional biopsy (endoscopic biopsy, Trucut biopsy, surgical incisional biopsy) and treated medically; only one patient had had surgical resection of the mass. Clinical signs at the time of recurrence or progression were inconsistent. Feline gastrointestinal eosinophilic sclerosing fibroplasia shows ultrasonographic features similar to neoplasia but commonly demonstrates hyperechoic areas. Data were assessed for normality and then assessed with appropriate parametric or nonparametric tests accordingly. Progression of the disease at any time during the follow-up was more common in cats treated medically than those treated surgically (P = .02). Clinical signs may or may not be present at the time of ultrasonographic recurrence or progression.
- Klíčová slova
- feline gastrointestinal mass, gastrointestinal eosinophilic sclerosing fibroplasia, ultrasound,
- MeSH
- enteritida veterinární diagnostické zobrazování patologie MeSH
- eozinofilie * veterinární diagnostické zobrazování patologie MeSH
- gastritida veterinární diagnostické zobrazování patologie MeSH
- kočky MeSH
- následné studie MeSH
- nemoci koček * diagnostické zobrazování patologie chirurgie MeSH
- retrospektivní studie MeSH
- ultrasonografie * veterinární MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
Duodenum is currently the most popular site to obtain samples of intestinal mucosa for recognition of a disorder leading to malabsorption. Although there are significant overlaps between histological findings described in various non-neoplastic diseases of the duodenum, recognition of one of the six basic morphologic patterns, namely coeliac disease-like pattern, active chronic duodenitis, acute GvHD-like pattern, enteritis with predominant eosinophilic infiltration, enteritis with predominant infiltration by macrophages, and non-inflammatory enteropathy, usually allows diagnostic separation, especially if subtle histological details, clinical setting and serological investigation are taken into account.
- Klíčová slova
- Biopsy, duodenitis, duodenopathy, duodenum, endoscopy, pattern,
- MeSH
- biopsie MeSH
- celiakie * diagnóza patologie MeSH
- duodenitida * diagnóza patologie MeSH
- duodenum patologie MeSH
- enteritida * diagnóza patologie MeSH
- lidé MeSH
- střevní sliznice patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Common variable immunodeficiency (CVID) is the most frequent clinically relevant primary immunodeficiency and shows enormous heterogeneity in clinical presentation. Despite clinical immunodeficiency, opportunistic infections are not a typical manifestation of CVID. A retrospective study of 32 patients followed up for 335 patient-years was performed to determine the frequency of cytomegalovirus (CMV) disease. Symptomatic CMV infection was documented in 3 CVID patients. Patients No. 1 and 2 suffered from CMV pneumonia, with complications due to atypical mycobacteriosis in patient No. 1. Patient No. 3 suffered from CMV enteritis. A history of cancer and chronic hepatitis C infection (patient No. 1), immunosuppressive therapy for interstitial lung disease (patient No. 2) and serious enteropathy complicated with malnutrition (patient No. 3) may have contributed to the complications despite only mild abnormalities in T-cell subpopulations. The direct detection of CMV in bronchoalveolar lavage, stool or tissue samples was the most beneficial diagnostic laboratory method, whereas the detection of CMV DNA in blood did not produce positive results. Adequate treatment of CMV disease led to significant clinical improvement in all 3 patients. The frequency of CMV disease appears to be higher than previously described. In our experience, the probability of opportunistic infections in CVID patients increases with secondary comorbidities and their management.
- MeSH
- atypické mykobakteriální infekce komplikace diagnóza patologie virologie MeSH
- běžná variabilní imunodeficience komplikace diagnóza patologie virologie MeSH
- bronchoalveolární lavážní tekutina virologie MeSH
- cytomegalovirové infekce komplikace diagnóza patologie virologie MeSH
- Cytomegalovirus MeSH
- DNA virů izolace a purifikace MeSH
- enteritida komplikace diagnóza patologie virologie MeSH
- feces virologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- virová pneumonie komplikace diagnóza patologie virologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
- Názvy látek
- DNA virů MeSH
Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare condition characterised by chronic or relapsing moderate ileous episodes resulting from multiple small intestinal strictures, multiple shallow ulcers of the small bowel and favourable therapeutical effect of glucocorticosteroids. The aim of this paper was to evaluate three cases of CMUSE diagnosed within 10 years at a tertiary gastroenterology centre. Three females (35, 50, 60 years) were presented with colicky pain, repeated moderate ileous episodes and weight loss. Multiple fibrous strictures and ulcers of the small bowel were found. All three patients responded to glucocorticosteroid treatment. Tandem tight jejunal stenoses were dilated endoscopically by means of double balloon enteroscopy. In conclusion, CMUSE should always be considered when chronic moderate ileous episodes and multiple small intestinal strictures and ulcers of uncertain aetiology are found. Double balloon enteroscopy enables precise diagnostic work, possible endoscopic treatment of stenoses, may obviate the need for surgery and prevent excessive small bowel resections.
- MeSH
- dospělí MeSH
- enteritida komplikace patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- střevní obstrukce komplikace patologie MeSH
- tenké střevo patologie MeSH
- vřed komplikace patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- práce podpořená grantem MeSH
Gastrointestinal form is the second stage of the Acute Radiation Syndrome (ARS) with a threshold dose of 8 Gy. It represents an absolutely lethal clinical-pathological unit, enteritis necro-hemorrhagica (duodenitis, jejunitis, ileitis, respectively) with unknown causal therapy. The purpose of our study has been to evaluate the morphological changes in a model of radiation-induced enteritis in rats and estimate the significance of changes in biodosimetry. Wistar rats were randomly divided into 21 groups, 10 animals per group. Samples of the jejunum were taken 24, 48, 72, and 96 h after the whole-body gamma-irradiation with the doses of 1, 5, 10, 15, and 20 Gy, and routinely stained with hematoxylin and eosin. Five morphometric markers--intercryptal distance, enterocytal height on the top and base of villus, length of basal lamina of 10 enterocytes and enterocytal width--in irradiated rat jejunum were examined. The results were compared with sham-irradiated control group. After lethal doses of irradiation, all morphometric parameters of jejunum significantly changed. With the exception of intercryptal distance, they might be considered as suitable biodosimetric markers under these experimental conditions. Our morphometry results in radiation-induced jejunitis are in accordance with those in other studies. We were the first who quantified morphological post-irradiation changes in animal jejunum. Some of them might be used under experimental conditions. This experimental study is a predecessor of the clinical assessment of a specific marker. Under clinical practice, the sensitive biodosimetric parameter could serve as one of the guidance for evaluation of the absorbed dose in irradiated troops as well as rescue workers. This is in accordance with tasks and Standardization Agreement of the North Atlantic Treaty Organization.
- MeSH
- bazální membrána patologie účinky záření MeSH
- časové faktory MeSH
- celotělové ozáření * MeSH
- enteritida etiologie patologie MeSH
- enterocyty patologie účinky záření MeSH
- experimentální radiační poranění patologie MeSH
- hodnocení rizik MeSH
- jejunum patologie účinky záření MeSH
- krysa rodu Rattus MeSH
- nemoci jejuna etiologie patologie MeSH
- potkani Wistar MeSH
- radiometrie MeSH
- vztah dávky záření a odpovědi MeSH
- záření gama * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
In 1985, a histopathological examination was conducted in the ileum and a parasitological examination in the ileum and rectum of 345 emergency slaughtered calves. The pathogenic role of cryptosporidia was compared in two groups of calves: group A contained 184 calves (53.3%) with scours and enteritis, group B contained 161 calves (46.7%) with other types of disease. In both groups the calves were divided into four age categories: 7 to 10 days (7.8%), 11 to 14 days (29.3%), 15 to 21 days (53.0%), 22 days and older (9.9%). During the parallel examination by both methods, cryptosporidia were detected in 124 cases, i.e. at the total invasion extensity of 35.93%; in group A the cryptosporidia were found in 76 cases (22.02%) and in the group B in 48 cases (13.91%). As indicated by the results, cryptosporidiosis is a disease of polyfactorial origin and cryptosporidia must be taken into account as one of the enteropathogenic factors in the etiology of scours. It is confirmed by the positive findings of cryptosporidia in the calves of group B (29.81%) and the negative finding in group A (31.3%) that no clear relationship was demonstrated to exist between the positive findings of these protozoans and the clinical symptoms of the diseases and enteritis. The pathogenesis of cryptosporidiosis includes significant regressive changes in the microvillous layer and enterocytes, which were a common finding at heavy invasions. The total positivity of the findings of cryptosporidia in the ileum was significantly higher (by 14.8%) during the histopathological examination, as compared with the parasitological examination. Out of the total positive findings, 39 cases (31.5%) were demonstrated histopathologically. During the parasitological examination, the positivity of the findings of cryptosporidia was higher by 4.3% in the rectum than in the ileum. When there was conducted a parallel parasitological examination of the ileum and rectum, the total positivity was higher by 7.5% than at the histopathological examination in the ileum. The highest invasion extensity was found at the age of 7 to 10 days in both groups of calves. The highest invasion intensity was found at the age of 11 to 21 days in both groups. The age until the 21st day when the parasitosis is intensively spread is considered as the most dangerous age of the calves from the epizootological point of view. Cryptosporidia occurred all the year round, no characteristic seasonal patterns were observed. The total average invasion extensity of the 24 farms from where the calves came was 42.3%, its range being from 0 to 85.7%.
- MeSH
- Cryptosporidium izolace a purifikace MeSH
- enteritida etiologie mikrobiologie patologie veterinární MeSH
- nemoci skotu mikrobiologie patologie MeSH
- průjem etiologie mikrobiologie patologie veterinární MeSH
- skot MeSH
- zvířata MeSH
- Check Tag
- skot MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
The results of a post-mortem examination of 15 dogs suffering from acute viral infection probably of parvoviral etiology, are described. The characteristical finding was an acute catarhally hemorrhagic or even a hemorrhagically necrotic enteritis, eventually a colitis with isolated intranuclear inclusions in the epithelium of the crypts, there was also a marked depletion of lymphocytes in the lymphatic organs and some atrophy of the bone marrow.
- MeSH
- akutní nemoc MeSH
- enteritida patologie veterinární MeSH
- nemoci psů patologie MeSH
- Parvoviridae MeSH
- psi MeSH
- střeva patologie MeSH
- virové nemoci patologie veterinární MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
A description of the findings in a parvoviral epizooty, having occurred in a confined colony of 250 Beagle dogs in the autum and winter 1979-1980 and in 1981, is presented. 5 of the four month-old and older dogs perished in the course of an enteritic form of infection; 5 puppies, younger than 3 months, belonging to a group of 12 puppies derived from two infected litters, died in consequence of a parvoviral myocarditis. The simultaneous occurrence of myocarditis and enteritis was observed in a 9 day-old puppy. Among the seven remaining animals, two dogs were sacrificed at the ages of 18 and 23 months, respectively. Scars were found in the wall of the left ventricle of both of them. Parvoviral enteritis preceded the occurrence of parvoviral myocarditis. Characteristic intramuscular inclusions were demonstrated both in the enterocytes and in the myocardial cells. Electronmicroscopically particles of the size of the parvoviruses could be demonstrated in the nuclei of the myocardial cells, on one hand, and regressive changes of the nuclear components observed on the other hand.
- MeSH
- enteritida patologie veterinární MeSH
- myokarditida patologie veterinární MeSH
- nemoci psů patologie MeSH
- Parvoviridae MeSH
- psi MeSH
- virové nemoci epidemiologie patologie veterinární MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- psi MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Geografické názvy
- Československo MeSH
The changes observed in the submicroscopic structure of the enterocytes of the jejunum of lambs in which inflammation has been chemically evoked justify the assumption that 12 hours after application of the chemical agent some differences exist, particularly in cellular reaction in the submucosa, in comparison with inflammations evoked by the infective agent. The submicroscopic changes in the enterocytes correspond to acute inflammation and indicate alterations on cell components which considerably reduce the absorptive area of the intestinal epithelium, and on organellae essential for the function of the enterocyte. In this way the natural barriers in the intestinal wall are damaged, leading to derangements in the absorption and passage of the nutrients taken in.
- MeSH
- buněčná membrána MeSH
- elektronová mikroskopie metody MeSH
- enteritida patologie veterinární MeSH
- fagocytóza MeSH
- lymfocyty fyziologie MeSH
- nemoci ovcí patologie MeSH
- ovce MeSH
- tenké střevo ultrastruktura MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- MeSH
- biopsie MeSH
- chronická nemoc MeSH
- endoskopie MeSH
- enteritida diagnóza patologie MeSH
- lidé MeSH
- nemoci duodena diagnóza patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
