GHS predictive Index
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The use of lower cut-off values/concentration limits for the calculation of mixture classification in UN GHS/EU CLP versus the previous regulatory scheme (EU Dangerous Preparations Directive, DPD), has resulted in an increased number of classifications in the highest eye hazard category. Herein, a semi-quantitative categorisation of severity of eye effects, following accidental human exposures to detergents, was compared to the classification category of the products. Three schemes were evaluated: EU DPD; EU CLP (based on all available data and information, including weight of evidence); and EU CLP (based entirely on the calculation method). As reported by four EU Poison Centres, the vast majority of exposures had caused minor or no symptoms. Classification was a poor predictor of effects in man subjected to accidental exposure. Note however that this is also because effects are not only driven by the intrinsic hazard (as reflected in the classification), but also by the exposure conditions and mitigation (i.e. rinsing). EU CLP classification using all available data and information was more predictive of medically relevant symptoms than the EU CLP calculation method. The latter led to a poorer differentiation between irritating products versus products potentially causing serious eye damage.
- Klíčová slova
- Accidental eye exposure, Detergents and cleaning products, EU CLP, EU DPD, Eye hazard classification category, Poisoning severity score (PSS), UN GHS,
- MeSH
- detergenty toxicita MeSH
- dráždivé látky toxicita MeSH
- lidé MeSH
- poranění oka klasifikace etiologie MeSH
- toxikologická centra MeSH
- ukazatel závažnosti úrazu MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- detergenty MeSH
- dráždivé látky MeSH
The COVID-19 pandemic in the first months of 2020 posed an unprecedented threat to the health of the world's population. In this longitudinal design study, we elaborated the typology of 27 European countries based on the complete beginnings of the ongoing COVID-19 pandemic based on health indicators and contextual variables. Two-step analysis using factor scores to run a cluster analysis identifying 5 consistent groups of countries. We then analyze the relationship between the GHS predictive index, the restrictions and health care expenditures within countries categorized into 5 clusters. An analysis of the early stages of a pandemic confirmed that in countries where anti-pandemic measures were rapidly and consistently in place, the spread of the virus was suppressed more rapidly and the first wave of pandemics in these countries was incomparably more benign than in countries with later responses and milder restrictive measures.
- Klíčová slova
- COVID-19 pandemic, European countries, Factory and cluster analyses, GHS predictive Index, Suppression and mitigation, Typology,
- Publikační typ
- časopisecké články MeSH
The prevalence of sleep apnea syndrome (SAS) in acromegaly is high. Consequences of SAS are serious and are associated with increased morbidity and mortality. The aim of this study was to assess the relative frequency and predictive factors for SAS in a group of patients with acromegaly (n=55). The presence of SAS was evaluated using the Polymesam device. Hormonal and clinical examination consisted of assessment of growth hormone, insulin-like growth factor I plasma levels, body mass index (BMI), neck circumference, age, sex, treatment modes of acromegaly and ear, nose and throat (ENT) examination. The relative frequency of SAS in our group of patients with acromegaly was 75%. Independent predictors of SAS were: increased activity of acromegaly, higher age and neck circumference. No association between SAS and BMI and ENT findings was observed. The role of gender was controversial.
- MeSH
- akromegalie komplikace terapie MeSH
- biometrie MeSH
- dospělí MeSH
- index tělesné hmotnosti MeSH
- insulinu podobný růstový faktor I analýza MeSH
- krk MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidský růstový hormon krev MeSH
- pohlavní dimorfismus MeSH
- senioři MeSH
- stárnutí MeSH
- syndromy spánkové apnoe komplikace diagnóza epidemiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- insulinu podobný růstový faktor I MeSH
- lidský růstový hormon MeSH
The aim of the present study was to assess the long-term outcomes of women 3-to-11 years postpartum in relation to the previous occurrence of pregnancy-related complications such as gestational hypertension (GH), preeclampsia (PE) and fetal growth restriction (FGR). Body mass index (BMI), waist circumference values, the average values of systolic (SBP) and diastolic (DBP) blood pressures and heart rate, total serum cholesterol levels, serum HDL (high-density lipoprotein) cholesterol levels, serum LDL (low-density lipoprotein) cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum CRP (C-reactive protein) levels, plasma homocysteine levels, serum uric acid levels, individual and relative risks of having a heart attack or stroke over the next ten years were compared between groups (50 GH, 102 PE, 34 FGR and 90 normal pregnancies) and correlated with the severity of the disease with regard to clinical signs (25 PE without severe features, 77 PE with severe features), and delivery date (36 early PE, 66 late PE). The adjustment for potential covariates was made, where appropriate. At 3-11 years follow-up women with a history of GH, PE regardless of the severity of the disease and the delivery date, PE without severe features, PE with severe features, early PE, and late PE had higher BMI, waist circumferences, SBP, DBP, and predicted 10-year cardiovascular event risk when compared with women with a history of normotensive term pregnancy. In addition, increased serum levels of uric acid were found in patients previously affected with GH, PE regardless of the severity of the disease and the delivery date, PE with severe features, early PE, and late PE. Higher serum levels of lipoprotein A were found in patients previously affected with early PE. The receiver operating characteristic (ROC) curve analyses were able to identify a substantial proportion of women previously affected with GH or PE with a predisposition to later onset of cardiovascular diseases. Women with a history of GH and PE represent a risky group of patients that may benefit from implementation of early primary prevention strategies.
