OBJECTIVES: Autism is a severe neurodevelopmental disorder with a high rate of epilepsy and subclinical epileptiform activity. High physical connectivity on a microcolumnar level leading to epileptiform activity and low functional informational connectivity are assumed in autism. The aim of this study was to investigate nonlinear EEG brain dynamics in terms of synchronization in a group of children with autism spectrum disorders compared to a control group. We expected a lower degree of synchronization in autistic subjects. METHODS: The autistic group consisted of 27 patients with autism spectrum disorders diagnosed according to ICD-10. The mean age of the sample was 7.1 (SD 3.6) years, 14 of them were mentally retarded. Normal EEG was found in 9 patients, epileptiform EEG in 18 autistic patients. Four patients had a history of epileptic seizures, fully compensated in long term. The control group consisted of 20 children (mean age of 8.4, SD 2.3 years) with normal intelligence, without an epileptic history, investigated within the frame of the research program for cochlear implantation. They had normal neurological examination and suffered from perceptive deafness. Normal EEG was found in 17 of the control subjects, epileptiform EEG was in 3 control subjects. We analyzed night sleep EEG recordings from 10 channels (F3, F4, F7, F8, C3, C4, T3, T4, P3 and P4) with the inclusion of sleep stages NREM 2, 3 and 4 in the subsequent analyses. Coarse-grained entropy information rates between neighbouring electrodes were computed, expressing the synchronization between 11 selected electrode couples. RESULTS: Synchronization was significantly lower in the autistic group in all three examined NREM stages even when age and intelligence were taken into account as covariates. CONCLUSIONS: The results of the study confirmed the validity of the underconnectivity model in autism.

• MeSH
• autistická porucha patofyziologie   MeSH
• dítě MeSH
• elektroencefalografie * MeSH
• lidé MeSH
• mentální retardace patofyziologie   MeSH
• polysomnografie MeSH
• předškolní dítě MeSH
• spánek fyziologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• předškolní dítě MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

The aim of the present research has been to determine whether there is a relationship between brain abnormalities found on magnetic resonance imaging (MRI) and autistic psychopathology. A retrospective analysis covering a period between 1998 and 2015 included 489 children with autism (404 boys, 85 girls; average age 8.0 ± 4.2 years) who underwent an MRI of the brain. For clinical diagnosis of autism, the International Classification of Diseases, 10th revision (ICD-10), was used. Autistic psychopathology was evaluated by means of the Autism Diagnostic Interview - Revised. The Spearman nonparametric correlation analysis and chi-square test were used to examine the possible relationships between variables. The group of autistic children did not manifest a statistically significant correlation between the parameters examined on MRI and autistic psychopathology. A correlation between other cysts and repetitive behavior was significant only at trend level (P = 0.054). Gliosis of the brain was significantly more frequent in autistic children with mental retardation than in children without mental retardation (14.1% vs. 7.4%; P = 0.028). Nonmyelinated areas in the brain were significantly more frequent in autistic children with autistic regression than in children without autistic regression (29.9% vs. 15.7%; P = 0.008). Mental retardation was significantly more frequent in autistic children with autistic regression than in children without regression (73.2% vs. 52.5%; P = 0.002). Our research study did not reveal a statistically significant correlation of brain abnormalities on MRI with autistic psychopathology.

• Klíčová slova
• Autism, Brain, MRI, Psychopathology,
• MeSH
• autistická porucha * komplikace   MeSH
• dítě MeSH
• lidé MeSH
• mentální retardace * MeSH
• mozek diagnostické zobrazování   MeSH
• předškolní dítě MeSH
• retrospektivní studie MeSH
• vývojové poruchy u dětí MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

The purpose of the present study was to examine the buffering effect of parental mediation of technology use and social support from parents on the association between cyber victimization and depression, assessed over one year. Participants were 113 7th through 9th graders from the Midwestern United States (age ranged from 12 to 17 years old; 86% were male) who were diagnosed with autism spectrum disorder. They completed questionnaires on their perceptions of parental mediation of technology use, perceived social support from parents, and self-reported face-to-face and cyber victimization and depression at Wave 1. One year later, at Wave 2, they completed a questionnaire on their depression. Results indicated that the associations between cyber victimization and depression were more negative at higher levels of perceived parental technology mediation and social support, while these associations were more negative at lower levels of these variables, after controlling for face-to-face victimization and Wave 1 depression.

• Klíčová slova
• Asperger syndrome, Autistic disorder, Cyber aggression, Cyberbullying, Pervasive developmental disorder,
• Publikační typ
• časopisecké články MeSH

The aim of our study was to explore possible differences in estimation of odor pleasantness in children with autism spectrum disorders (ASD) compared to controls. Thirty-five patients with Asperger's syndrome and high functioning autism (mean age 10.8 ± 3.6 years; 31 boys) were compared with 35 healthy control subjects (mean age 10.4 ± 2.4 years; 28 boys). Odor pleasantness was assessed on a 5-point scale using the Sniffin' Sticks test (Identification part of the test). Patients with ASD, compared to healthy controls, perceived the smell of cinnamon and pineapple as significantly less pleasant (p < 0.05); at the trend level, the same was true of cloves (p < 0.1). The possibility of olfactory dysfunctions as an autism biomarker is discussed.

• MeSH
• čich fyziologie   MeSH
• čichová percepce fyziologie   MeSH
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• odoranty MeSH
• pervazivní vývojové poruchy u dětí psychologie   MeSH
• radost * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

AIMS: The aim of our study was to assess the yield of routine brain magnetic resonance imaging (MRI) performed at our hospital as part of the diagnostic procedures focused on autism. METHODS: Our retrospective study involved children who had attended a diagnostic examination focused on autism and underwent brain MRIs between 1998-2015. The International Classification of Diseases, 10th edition was used to make clinical diagnoses. In 489 children (404 boys, 85 girls; mean age 8.0±4.2 years), a diagnosis of a pervasive developmental disorder was confirmed. Forty-five children, where the autism diagnosis was ruled out (but other psychiatric diagnoses found), served as a control group (36 boys, 9 girls; mean age 7.0±2.4 years). We can assume that in such a control group, brain abnormalities might occur at a higher frequency than in truly healthy children which would have the effect of reducing the difference between the groups. RESULTS: MRI pathologies were more common in the autistic (45.4 %) compared to the control group (31.8%) but the difference was significant only at the trend level (P=0.085). Hypoplasia of the corpus callosum (CC) was significantly more common in the autistic vs. the control group (13.7 vs. 0%; P=0.009). In contrast, nonmyelinated areas of white matter were significantly more common in controls (31.8 vs.17.3%; P=0.018). Differences in other parameters were not significant. CONCLUSION: The occurrence of CC hypoplasia on routine MRI scans could represent a "red flag" for suspicion of autism.

• Klíčová slova
• MRI, autism spectrum disorders, brain, corpus callosum,
• MeSH
• autistická porucha diagnostické zobrazování   MeSH
• dítě MeSH
• lidé MeSH
• magnetická rezonanční tomografie metody   MeSH
• mladiství MeSH
• mozek diagnostické zobrazování   patofyziologie   MeSH
• poruchy autistického spektra diagnóza   MeSH
• předškolní dítě MeSH
• retrospektivní studie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

In the world literature findings of morphological abnormalities in the area of the brain and cerebellum in children with pervasive developmental disorders are encountered. The authors of the present article describe in three case-records morphological abnormalities of the brain and cerebellum found in subjects with markedly expressed or only indicated signs of child autism. At the same time they draw attention to the possible determination of experience and behaviour of subjects with discrete morphological abnormalities, even when the pervasive developmental disorder was not diagnosed but where specific determination of premorbid experience and behaviour, as well as the clinical picture of a possible mental disorder or disease.

• MeSH
• autistická porucha diagnostické zobrazování   etiologie   patologie   MeSH
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mozek diagnostické zobrazování   patologie   MeSH
• počítačová rentgenová tomografie MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Rett syndrome is one of the leading causes of mental retardation and developmental regression in girls. It is characterized by a period of normal psychomotor development followed by the loss of acquired motor and communication skills, autistic features and stereotypic hand movements. Rett syndrome is the first pervasive developmental disorder with a known genetic cause. The majority of cases are caused by de novo mutations in an X-linked MECP2 gene. Its product, methyl-CpG-binding protein 2, plays an important role in the regulation of gene expression and chromatin structure. Because the neuropathology of Rett syndrome shares certain features with other neurodevelopmental disorders, a common pathogenic process may underlie these disorders. This makes Rett syndrome a prototype for the genetic, molecular, and neurobiological analyses of neurodevelopmental disorders.

• MeSH
• lidé MeSH
• mutace MeSH
• protein 2 vázající methyl-CpG genetika   MeSH
• Rettův syndrom diagnóza   genetika   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• protein 2 vázající methyl-CpG MeSH