BACKGROUND: This 52-week study evaluated the long-term safety and tolerability of capsaicin 8% w/w (179 mg) patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy (PDPN). METHODS: Phase 3, multinational, open-label, randomised, controlled, 52-week safety study, conducted in Europe. Patients were randomised to capsaicin 8% patch repeat treatment (30 or 60 min; 1-7 treatments with ≥ 8-week intervals) to painful areas of the feet plus SOC, or SOC alone. The primary objective was the safety of capsaicin 8% patch repeat treatment (30 min and 60 min applications) plus SOC versus SOC alone over 52 weeks, assessed by changes in Norfolk Quality of Life-Diabetic Neuropathy (QOL-DN) total score from baseline to end of study (EOS). Secondary safety endpoints included Utah Early Neuropathy Scale (UENS) assessments and standardised testing of sensory perception and reflex function. RESULTS: Overall, 468 patients were randomised (30 min plus SOC, n = 156; 60 min plus SOC, n = 157; SOC alone, n = 155). By EoS, mean changes in Norfolk QOL-DN total score from baseline [estimated mean difference versus SOC alone; 90% CI for difference] were: 30 min plus SOC, -27.6% [-20.9; -31.7, -10.1]; 60 min plus SOC, -32.8% [-26.1; -36.8, -15.4]; SOC alone, -6.7%. Mean changes [difference versus SOC alone] in UENS total score by EoS versus baseline were: 30 min plus SOC, -2.1 [-0.9; -1.8, 0.1]; 60 min plus SOC, -3.0 [-1.7; -2.7, -0.8]; SOC alone, -1.2. No detrimental deterioration was observed in any of the Norfolk or UENS subscales by EoS with capsaicin. Also, no worsening in sensory perception testing of sharp, warm, cold and vibration stimuli was found with capsaicin by EoS. Capsaicin treatment was well tolerated and the most frequent treatment-emergent adverse events were application site pain (30 min, 28.2%; 60 min, 29.3%), burning sensation (30 min, 9.0%; 60 min, 9.6%) and application site erythema (30 min, 7.7%; 60 min, 8.9%). CONCLUSION: In patients with PDPN, capsaicin 8% patch repeat treatment plus SOC over 52 weeks was well tolerated with no negative functional or neurological effects compared with SOC alone. TRIAL REGISTRATION: ClinicalTrials.gov registration: NCT01478607 . Date of registration November 21, 2011; retrospectively registered.
- Klíčová slova
- Capsaicin 8% patch, Norfolk QOL-DN, Painful diabetic peripheral neuropathy, TPRV1, UENS,
- MeSH
- aplikace kožní MeSH
- diabetické neuropatie komplikace farmakoterapie MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče * MeSH
- kapsaicin aplikace a dávkování škodlivé účinky MeSH
- látky ovlivňující senzorický systém aplikace a dávkování škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuralgie farmakoterapie etiologie MeSH
- senioři MeSH
- standardní péče * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze III MeSH
- multicentrická studie MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- kapsaicin MeSH
- látky ovlivňující senzorický systém MeSH
The proliferation of processing hardware alternatives allows developers to use various customized computing platforms to run their applications in an optimal way. However, porting application code on custom hardware requires a lot of development and porting effort. This paper describes a heterogeneous computational platform (the ALMARVI execution platform) comprising of multiple communicating processors that allow easy programmability through an interface to OpenCL. The ALMARVI platform uses processing elements based on both VLIW and Transport Triggered Architectures (ρ-VEX and TCE cores, respectively). It can be implemented on Zynq devices such as the ZedBoard, and supports OpenCL by means of the pocl (Portable OpenCL) project and our ALMAIF interface specification. This allows developers to execute kernels transparently on either processing elements, thereby allowing to optimize execution time with minimal design and development effort.
- MeSH
- AIDS epidemiologie etiologie MeSH
- dospělí MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Spojené státy americké MeSH
- MeSH
- adresáře jako téma * MeSH
- akademie a ústavy MeSH
- dítě MeSH
- lidé MeSH
- péče o dítě * MeSH
- služby zdravotní péče o dítě * MeSH
- státní lékařství MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- adresáře MeSH
- Geografické názvy
- Československo MeSH
In the context of salutogenesis, coping with diabetes is perceived as a dynamic process of changes in all aspects of biopsychosocial model of health/disease. Understanding of salutoprotective factors allows for estimation of client's extent of vulnerability and ability to cope with the disease. The objective of the study is to assess selected salutoprotective factors in diabetic clients (SOC-type hardiness, well-being-subjective feelings and states scale [SUPOS], perceived social support scale [PSSS]). Low values of SOC, PSSS, and SUPOS suggest an increased need in psychosocial care. The possibility to strengthen an individual's hardiness and to influence perceived social support adverts to the irreplaceable role of social workers at counseling and educational levels as well as that of a form of social support.
- Klíčová slova
- Hardiness, psychosocial care, salutogenesis, salutoprotective factors, social support,
- MeSH
- diabetes mellitus psychologie terapie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- podpora zdraví MeSH
- psychická odolnost MeSH
- self-management psychologie MeSH
- senioři MeSH
- sociální opora MeSH
- sociální práce metody MeSH
- životní smysluplnost * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Long-term fertilization has shown a high relevance as regards soil organic carbon (SOC) sequestration, but the degree of stability of the sequestered SOC has not been widely studied up to now. Using physical fractionation combined with laboratory incubation and NMR spectroscopy, we evaluated the differences in SOC stability caused by long-term fertilization. Four SOC fractions were isolated and examined for contents and chemical composition and cumulative amount of CO2-C respired from the fractions under six fertilization treatments: control (CK); balanced inorganic fertilization (NPK); NPK combined with pig manure (MNPK); NPK combined 1.5 times of pig manure (1.5MNPK); and NPK combined with high amount of manure (M2NPK). The highest contents of SOC were recorded for the coarse particulate organic carbon (cPOC) fraction, ranging from 17.25 to 30.47 g kg-1 under CK and M2NPK. The highest cumulative amount of CO2-C was released from the cPOC fraction under manure treatments (M2NPK and 1.5NPKM), which was 56 and 43% higher than that from CK, whereas the lowest amount of CO2-C was released from the mineral associated-C (MOC) fraction under the same treatments, being 65 and 49% higher than that released from CK, suggesting low SOC stability in cPOC and high SOC stability in MOC fractions. However, manure treatments (M2NPK and 1.5NPKM) greatly lowered the specific amount of C-mineralized (C-mineralized per unit total SOC) in fractions and whole soil, suggesting the ability of manure to accumulate more SOC by reducing SOC losses. Moreover, carbonyl-C was found to be the form of SOC experiencing major degree of sequestration under current fertilization practices. The SOC stability indices; aromaticity index (AI), hydrophobicity index (HI) and alkyl-C/O-alkyl-C were found to be higher in manure treated plots further suggesting higher stability of SOC under manure addition. Thus, long-term manure combined with mineral fertilizers would enhance SOC stability through minimizing SOC losses and promoting accumulation of stable C forms in a Chinese Mollisol.
- Klíčová slova
- Aromaticity, Fertilization, Mineralization, Mollisol, Pig manure, SOC fractionation,
- MeSH
- fertilizace MeSH
- hnůj analýza MeSH
- magnetická rezonanční spektroskopie MeSH
- prasata MeSH
- průmyslová hnojiva analýza MeSH
- půda * chemie MeSH
- uhlík * analýza MeSH
- zemědělství metody MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- hnůj MeSH
- průmyslová hnojiva MeSH
- půda * MeSH
- uhlík * MeSH
The mechanical reliability of reversible solid oxide cell (SOC) components is critical for the development of highly efficient, durable, and commercially competitive devices. In particular, the mechanical integrity of the ceramic cell, also known as membrane electrolyte assembly (MEA), is fundamental as its failure would be detrimental to the performance of the whole SOC stack. In the present work, the mechanical robustness of an electrolyte-supported cell was determined via ball-on-3-balls flexural strength measurements. The main focus was to investigate the effect of the manufacturing process (i.e., layer by layer deposition and their co-sintering) on the final strength. To allow this investigation, the electrode layers were screen-printed one by one on the electrolyte support and thus sintered. Strength tests were performed after every layer deposition and the non-symmetrical layout was taken into account during mechanical testing. Obtained experimental data were evaluated with the help of Weibull statistical analysis. A loss of mechanical strength after every layer deposition was usually detected, with the final strength of the cell being significantly smaller than the initial strength of the uncoated electrolyte (σ₀ ≈ 800 MPa and σ₀ ≈ 1800 MPa, respectively). Fractographic analyses helped to reveal the fracture behavior changes when individual layers were deposited. It was found that the reasons behind the weakening effect can be ascribed to the presence and redistribution of residual stresses, changes in the crack initiation site, porosity of layers, and pre-crack formation in the electrode layers.
- Klíčová slova
- SOC, ball-on-3-balls test, flexural biaxial test, fractography, mechanical strength, residual stresses,
- Publikační typ
- časopisecké články MeSH
Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus kinases and signalling molecules to regulate signalling pathways, thus controlling immune and inflammatory responses. Dysregulated expression of various types of SOCS molecules was indicated in multiple types of allergic diseases. SOCS1, SOCS2, SOCS3, SOCS5, and cytokine-inducible SH2 domain protein (CISH) can differentially exert anti-allergic impacts through different mechanisms, such as suppressing Th2 cell development and activation, reducing eosinophilia, decreasing IgE production, repressing production of pro-allergic chemokines, promoting Treg cell differentiation and activation, suppressing Th17 cell differentiation and activation, increasing anti-allergic Th1 responses, inhibiting M2 macrophage polarization, modulating survival and development of mast cells, reducing pro-allergic activity of keratinocytes, and suppressing pulmonary fibrosis. Although some anti-allergic effects were attributed to SOCS3, it can perform pro-allergic impacts through several pathways, such as promoting Th2 cell development and activation, supporting eosinophilia, boosting pro-allergic activity of eosinophils, increasing IgE production, enhancing the expression of the pro-allergic chemokine receptor, reducing Treg cell differentiation, increasing pro-allergic Th9 responses, as well as supporting mucus secretion and collagen deposition. In this review, we discuss the contrasting roles of SOCS proteins in contexts of allergic disorders to provide new insights regarding the pathophysiology of these diseases and possibly explore SOCS proteins as potential therapeutic targets for alleviating allergies.
- Klíčová slova
- SOCS molecules, T cells, allergic diseases, cytokines, immunopathology responses,
- MeSH
- alergie * metabolismus MeSH
- antialergika * MeSH
- cytokiny metabolismus MeSH
- eozinofilie * MeSH
- imunoglobulin E metabolismus MeSH
- lidé MeSH
- proteiny SOCS genetika metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antialergika * MeSH
- cytokiny MeSH
- imunoglobulin E MeSH
- proteiny SOCS MeSH
- Publikační typ
- časopisecké články MeSH
- tisková chyba MeSH
In situ visible and near-infrared (Vis-NIR) spectroscopy has proven to be a reliable tool for determining soil organic carbon (SOC) content with a small loss of precision as compared to laboratory measurements. The loss of precision is a result of disturbing external environmental factors that disrupt spectral measurements. For example, roughness, changes in weather conditions, humidity, temperature, human factors, spectral noise and especially soil water. It has been assumed that, in situ predictive capability could be improved if some of these factors are either minimized or eliminated during the in situ measurement. For this study, the prediction of SOC was carried out under two different in situ measurement conditions; less favourable environmental conditions (with disturbances) and more favourable site-specific conditions (disturbance-reduced conditions). The primary goal is to determine whether the estimate of SOC can be improved under more favourable site-specific conditions, as well as the impact of pre-treatment algorithms on both less and more favourable disturbed conditions. The study employed a large range of pretreatment algorithms and their combinations. Three separate multivariate models were used to predict SOC, namely Cubist, support vector machine regression (SVMR), and partial least squares regression (PLSR). The result clearly shows that reduced disturbing factors (i.e., drier and unploughed soil as well as noise reduction) result in an improvement of SOC prediction with in situ Vis-NIR spectroscopy. The best overall result was achieved with SVMR (R2CV = 0.72, RMSEPcv = 0.21, RPIQ = 2.34). Although the combination of pre-treatment algorithms resulted in an improvement, overall, these pre-treatment algorithms could not compensate for the factors affecting the measured spectra with disturbance. Though the obtained result is promising, further study is still needed to disentangle the impacts and interactions of various disturbing factors for different soil types.
- Klíčová slova
- Agricultural soil, In situ spectroscopy, Machine learning algorithms, Pre-treatment algorithms, SOC,
- MeSH
- blízká infračervená spektroskopie metody MeSH
- lidé MeSH
- metoda nejmenších čtverců MeSH
- půda * chemie MeSH
- support vector machine MeSH
- uhlík * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- půda * MeSH
- uhlík * MeSH
