Modern medicine offers a wide spectrum of wound healing resources for acute or chronic wounds. Negative pressure wound therapy (NPWT) is a very effective method, allowing complicated defects and wounds to heal. The basic set is usually provided with various special accessories to facilitate the use and support safe application of NPWT to high-risk tissue. Selected case reports are presented herein to document the special use and combinations of materials in negative pressure wound therapy.

• Klíčová slova
• wound healing − pressure wound therapy − case reports,
• MeSH
• hojení ran MeSH
• terapie ran pomocí řízeného podtlaku * MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

INTRODUCTION: Deep neck infections represent severe inflammatory involvement of defined fascial spaces of the neck and are potentially life-threatening diseases. The etiology is most commonly odontogenic or tonsillogenic. The main complications are mediastinitis, septic shock and upper airway obstruction. Treatment is based on the administration of intravenous antibiotics and, in indicated cases, surgical drainage of abscess sites. Case report 1: A 7-year-old girl was treated by a general practitioner for acute tonsil-litis. CT scan with contrast medium was indicated due to worsening of the condition and neck movement. A large retropharyngeal abscess was not reliably found from the external approach, so the procedure was extended to tonsillectomy and transoral drain-age. The cause was probably a multilocular abscess with rigid membranous septa. Case report 2: A 65-year-old man with diabetes mellitus presents with odynophagia and infiltrate of the left side of the neck. CT scan showed a phlegmon in the left carotid space. Surgery was indicated after 24 hrs of ineffective conservative treatment. During the operation, extensive formed abscess lesions were found and drained. Case report 3: A 60-year-old woman was treated as an outpatient for tonsillitis, then at the regional ENT department with an incipient epiglottitis, and finally at a tertiary department with a diagnosis of deep neck infection extending from the epiglottis to the hyoid according to imaging examinations. Peroperative findings revealed even larger extent of abscess that extended down to the jugulum. Case report 4: A 57-year-old patient with peritonsillar abscess treated by incision and antibiotics in the regional ENT department. Despite the treatment instituted, the condition progressed and a parapharyngeal abscess developed, which had to be managed by tonsillectomy and external incision at a tertiary department, including postoperative intubation and several days of hospitalization in an ICU ward. CONCLUSION: Medical history, otorhinolaryngological examination and early head and neck contrast enhanced CT are essential in the diagnosis of deep cervical inflamma-tion. Modern therapeutic algorithms including a multidisciplinary approach, repeated CT scans and surgical revisions lead to reduced mortality, including patients with mediastinitis.

• Klíčová slova
• case report, deep neck infections, parapharyngeal abscess, retropharyngeal abscess,
• MeSH
• dítě MeSH
• krk * MeSH
• lidé středního věku MeSH
• lidé MeSH
• retrofaryngeální absces * diagnóza   chirurgie   MeSH
• senioři MeSH
• Check Tag
• dítě MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Morgagni hernia is a rare form of diaphragmatic hernia. It is a congenital defect of the diaphragm, often asymptomatic in adulthood and thus usually found only incidentally. Its treatment is predominantly surgical. This article presents three case reports of patients operated in our department.

• Klíčová slova
• diaphragmatic hernia − Morgagni hernia,
• MeSH
• bránice MeSH
• dospělí MeSH
• hiátová hernie * MeSH
• lidé MeSH
• vrozená brániční kýla diagnostické zobrazování   chirurgie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

AIM: Iridocorneal endothelial (ICE) syndrome is a rare disease characterized by abnormal proliferation and structural changes of the endothelium, obliteration of the iridocorneal angle, and anomalies of the iris. The consequence of these changes is secondary glaucoma and corneal decompensation. The etiology is unclear, and the syndrome more commonly affects middle-aged women. CASE REPORTS: In this article we present two different case studies of young patients diagnosed with ICE syndrome with complications. The first case report is about a young woman in whom surgical treatment of glaucoma and corneal edema was successful. On the other hand, the second report presents a complicated case of a 29-year-old patient whose treatment was not successful despite repeated interventions. CONCLUSION: This text highlights the complexity of ICE syndrome, the difficulty of its therapy and the importance of early diagnosis.

• Klíčová slova
• corneal diseases, iridocorneal endothelial syndrome, plasmapheresis, secondary glaucoma,
• MeSH
• dospělí MeSH
• glaukom komplikace   MeSH
• iridokorneální endoteliální syndrom * diagnóza   komplikace   MeSH
• lidé MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• Klíčová slova
• BREAST NEOPLASMS/case reports *, CARCINOMA/case reports *,
• MeSH
• chorobopisy * MeSH
• karcinom * MeSH
• lidé MeSH
• nádory prsu * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

We present 3 case-reports with penetrating abdominal injury from our practice in this article. An urgent laparotomy was performed in all cases because of haemodynamic instability or the mechanism of injury. Penetrative abdominal traumas are associated with a high risk of life-threatening intra-abdominal injuries, require urgent revision and are often accompanied by postoperative infections of the peritoneal cavity. In recent years, there has been a growing tendency towards mini-invasive approaches or even non-operative treatment. This trend is particularly evident in the United States of America, where doctors experience a higher number of penetrating injuries compared to the prevalent blunt force trauma in Europe. The authors describe the need to follow all recommended procedures in the pre-hospital and hospital phases of treatment of these patients and compare them with recent literature. Key words: penetrating abdominal trauma.

• Klíčová slova
• advanced trauma life support − damage control surgery, penetrating abdominal trauma − ATLS,
• MeSH
• laparotomie MeSH
• lidé MeSH
• penetrující rány * chirurgie   MeSH
• poranění břicha * chirurgie   MeSH
• retrospektivní studie MeSH
• tupá poranění * diagnostické zobrazování   chirurgie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Geografické názvy
• Evropa MeSH

Our study presents two cases of neurofibromatosis 2 (NF2) that have been diagnosed at the Ear, Nose, and Throat Department of Hradec Králové (Czech Republic). The first case involved a young man with a history of sudden hearing loss accompanied by tinnitus on the left side. The diagnosis of NF2 was made, and an operation for left acoustic neuroma was performed. Looking toward the future, the acoustic neuroma on the right side should be resolved as well. The second case concerned a woman (the mother of our patient 1) examined at the same Ear, Nose, and Throat Department in 1980, after 4 years of gait instability and progressive loss of hearing and tinnitus on the right side. Computed tomography scan detected a bilateral expansion in the pontocerebellar angles, and a large tumor on the right side was removed. The patient is deaf and has facial palsy without progression of symptomatology during long-term follow-up. These two cases document the rare but serious hereditary disease of NF2. Its most frequent first presentation is acoustic neuroma; further, benign tumors of the nervous system and juvenile cortical cataract also are often detected. The variability of number, location, and biological behavior of tumors associated with NF2 require an individual patient treatment approach, long-term follow-up, and insertion of appropriate hearing aids. Important also is a genetic examination to exclude pathological NF2 genes in the first-degree relatives of the affected individuals.

• MeSH
• faciální paralýza etiologie   MeSH
• hluchota etiologie   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• meningeom diagnóza   patofyziologie   chirurgie   MeSH
• nádory kraniálních nervů diagnóza   genetika   patofyziologie   chirurgie   MeSH
• náhlá nedoslýchavost patofyziologie   MeSH
• následné studie MeSH
• neurofibromatóza 2 diagnóza   genetika   patofyziologie   chirurgie   MeSH
• počítačová rentgenová tomografie MeSH
• sluchové kmenové evokované potenciály MeSH
• tinnitus patofyziologie   MeSH
• vestibulární schwannom diagnóza   patofyziologie   chirurgie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

INTRODUCTION: Causality of marijuana abuse with development of ischemic stroke has been indicated by numerous case reports and epidemiological studies. As a possible pathophysiological mechanism, the most common consideration is cardiac embolization during paroxysmal atrial fibrillation, systemic hypotension or multifocal intracerebral vasoconstriction. CASE REPORTS: We present three case reports of marijuana consumers who were admitted to our comprehensive stroke center due to ischemic stroke within 18-month period of our investigation. In one case, the cause of stroke was not related to the use of marijuana, it was a manifestation of antiphospholipid syndrome. In two cases the association with the abuse of this drug is probable but not certain. In both these cases, an isolated occlusion in vertebrobasilar arterial system was detected, without finding of a cerebral vessels stenosis. Although we did not register the atrial fibrillation, we consider cardiac embolization as probable etiological mechanism of stroke in both cases. In one case, paradoxical embolization due to the persistent foramen ovale represents another potential etiological mechanism. CONCLUSIONS: Cannabinoid use may cause ischemic stroke, especially in the younger age category. Therefore, in these patients we recommend focusing on the history of cannabinoid abuse and carry out toxicological urine tests.

• Klíčová slova
• cannabinoids, ischemic stroke, reversible cerebral vasoconstriction syndrome, vasospasms, young stroke,
• MeSH
• abúzus marihuany komplikace   MeSH
• cerebrální infarkt diagnostické zobrazování   etiologie   MeSH
• digitální subtrakční angiografie MeSH
• dospělí MeSH
• kouření marihuany škodlivé účinky   MeSH
• lidé MeSH
• mladý dospělý MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• Klíčová slova
• CARCINOMA/case reports *, SKIN NEOPLASMS/case reports *,
• MeSH
• chorobopisy * MeSH
• karcinom * MeSH
• kůže * MeSH
• lidé MeSH
• nádory kůže * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Epigenetic therapy with hypomethylating agent (5-azacytidine; AZA) is common in the management of specific subtypes of myelodysplastic syndrome (MDS), but there are only few studies in chronic myelomonocytic leukemia (CMML) patients. In this paper our experience with 3 CMML patients treated with AZA is described. In one patient transfusion independency was observed after 4 treatment cycles; in one case a partial response was recorded, but a progression to acute myeloid leukemia (AML) after 13 AZA cycles has appeared. In one patient, AZA in reduced dosage was administered as a bridging treatment before allogeneic stem cell transplantation (ASCT), but in the control bone marrow aspirate (before ASCT) a progression to AML was recorded. Future studies are mandatory for evaluation of new molecular and clinical features which could predict the efficiency of hypomethylating agents in CMML therapy with respect to overall survival, event-free survival, quality-adjusted life year, and pharmacoeconomy.

• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH