The left ventricular systolic function was studied in 123 healthy men aged 23-24 years under the influence of exercise and during a two-hour restitution period. Left ventricular systolic time intervals (LVSTI) were evaluated by means of the Blumberger method with Holldack's modification before the exercise, immediately after its termination and after 30, 60 and 120 minutes. After exercise, a decrease was found in the absolute values of LVSTI and of the diastolic stage. During two-hour restitution, the authors found a decrease of left ventricular ejection time, total mechanical systolic time, total electromechanical systolic time, total ventricular electrical stimulation time and of the diastolic stage. A statistically highly significant decrease of all mentioned intervals was related to persisting, still after 2 hours, increased heart rate with which these intervals significantly correlated. The share (in percent) of LVSTI in the total cardiac cycle increased after exercise and was still increased after 2 hours following its termination. The relative increase of systolic time intervals was accompanied by a decrease in the duration of the diastolic stage.

• MeSH
• dospělí MeSH
• funkční vyšetření srdce metody   MeSH
• lidé MeSH
• srdce - funkce komor * MeSH
• srdeční frekvence MeSH
• tělesná námaha MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• dospělí MeSH
• elektrodiagnostika * MeSH
• faciální paralýza diagnóza   MeSH
• fyziologická adaptace * MeSH
• lidé MeSH
• nemoci nervového systému diagnóza   MeSH
• nemoci svalů diagnóza   MeSH
• nervosvalové spojení patofyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

UNLABELLED: Single cases may lead to unexpected hypotheses in psychology. We retrospectively analyzed single case studies that suggested organizational principles along the early visual pathway, which have remained unanswered until now. FIRST CASE: In spite of the inhomogeneity of sensitivity, paradoxically the visual field on the subjective level appears to be homogeneous; constancy of brightness of supra-threshold stimuli throughout the visual field is claimed to be responsible for homogeneity; specific summation properties of retinal ganglion cells are hypothesized to guarantee this effect. SECOND CASE: With a brain-injured patient having suffered a partial visual field loss it can be shown that color induction is a retinal phenomenon; lateral inhibitory processes at the level of amacrine cells are hypothesized as neural network. Third case: In a patient having suffered a bilateral occipital lobe infarction, some functional recovery has been demonstrated; divergence and convergence of projection in the ascending neural pathway are suggested as a structural basis for recovery. Slowed down binocular rivalry discloses a sequential mechanism in the construction of a visual percept. Fourth case: The pre-wired projection of the retina to the visual cortex in spite of a severe squint of one eye is confirmed, but paradoxically some local neuroplasticity is also suggested. Fifth case: Using habituation of local sensitivity in the visual field and its resetting by interhemispheric interactions as an experimental paradigm, it is suggested that spatial attention is controlled at the midbrain level. Sixth case: Observations on residual vision or "blindsight" support the hypothesis that the visual cortex is the one and only structure responsible for visual perception on a conscious level. The unifying principle of these retrospective analyses is that subjective visual phenomena can lead to unexpected but testable hypotheses of neural processing on the structural and functional level in the early visual pathway.

• Klíčová slova
• attentional control, binocular rivalry, blindsight, brightness perception, color perception, consciousness, eccentricity effect, habituation, neuroplasticity, restitution of function,
• MeSH
• lidé MeSH
• metathalamus fyziologie   MeSH
• mozkový infarkt patofyziologie   MeSH
• poranění mozku patofyziologie   MeSH
• pozornost fyziologie   MeSH
• retina fyziologie   MeSH
• retrospektivní studie MeSH
• slepota patofyziologie   MeSH
• světelná stimulace MeSH
• vnímání barev MeSH
• zraková pole * MeSH
• zrakové dráhy fyziologie   MeSH
• zrakové korové centrum fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

The term homonymous hemianopia refers to visual impairment due to a post-chiasmatic brain lesion. Mammalian neurons of the central nervous system do not have the ability to regenerate. However, the cerebral cortex shows plasticity in certain cases. Motor or speech disorders due to frontal lobe brain damage can be improved with well-directed rehabilitation techniques. If such plasticity is possible, it raises the question whether specialized training could improve a cortical visual disorder. There is need for simple visual training which could be used in rehabilitation. A few different approaches have been developed to treat patients with hemianopia: (1) substitution including special devices, such as optical prisms; (2) compensation using intact residual abilities - especially training of eye movements; (3) restitution which is based on stimulating the blind hemifield. The third method of rehabilitation is the most controversial; however, it has the largest potential. To support concepts of the targeted rehabilitation outlined here, first: further development of the theory of plasticity in visual pathways is required and second: the efficacy of the rehabilitation procedures has to be demonstrated by clinical evidence. We review methods and approaches of hemianopia rehabilitation and treatment. We also review results of contemporary clinical studies and meta-studies.

• MeSH
• cévní mozková příhoda komplikace   MeSH
• hemianopsie etiologie   rehabilitace   MeSH
• lidé MeSH
• obnova funkce fyziologie   MeSH
• techniky fyzikální terapie * MeSH
• zraková pole fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

The intestinal environment accommodates a wide range of contents ranging from harmless beneficial dietary and microbial flora to harmful pathogenic bacteria. This has resulted in the development of highly adapted epithelial cells lining the intestine. This adaptation involves the potential of crypt cells to proliferate and to constantly replace villous cells that are lost due to maturity or death. As a result, the normal intestinal epithelial integrity and functions are maintained. This phenomenon is eminent in intestinal defense whereby the intestinal epithelial cells serve as a physical barrier against luminal agents. The protection against agents in the gut lumen can only be effective if the epithelium is intact. Restitution of the damaged epithelium is therefore crucial in this type of defense.

• MeSH
• antibióza * MeSH
• Bacteria * růst a vývoj   patogenita   MeSH
• bakteriální infekce mikrobiologie   prevence a kontrola   MeSH
• Caco-2 buňky MeSH
• epitelové buňky imunologie   metabolismus   mikrobiologie   MeSH
• gastrointestinální nemoci mikrobiologie   prevence a kontrola   MeSH
• lidé MeSH
• probiotika * MeSH
• proteiny teplotního šoku metabolismus   MeSH
• střeva cytologie   imunologie   mikrobiologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• proteiny teplotního šoku MeSH

Unilateral nephrectomy (UNX) is followed by a significant decrease of excreted amount of PAH in rats. In 105 and 240-day-old rats, we characterized the time course of restitution of the PAH transport process., Furthermore, we studied whether or not the regeneration of kidney function can be accelerated by repeated administration of cyclopenthiazide. After stimulation of tubular transport of PAH by repeated administration of cyclopenthiazide, the loss of one kidney after UNX can be compensated more rapidly as in nephrectomized rats without pretreatment. In 105-day-old rats the regeneration and the extent of stimulation are more marked than in 240-day-old rats.

• MeSH
• cyklopenthiazid farmakologie   MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• kyselina p-aminohippurová moč   MeSH
• kyseliny aminohippurové moč   MeSH
• ledviny fyziologie   MeSH
• nefrektomie * MeSH
• stárnutí * MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• cyklopenthiazid MeSH
• kyselina p-aminohippurová MeSH
• kyseliny aminohippurové MeSH

AIM: The aim of the presented work was to assess the causes of injury to great nerves during varicose vein surgery and comment on the consequences. METHODS: This was a retrospective study of 2344 patients operated on for primary varicose veins between the years 1980 and 2005. RESULTS: In three patients out of 2344 the peroneal nerve was injured. The three patients underwent neurosurgery. In the first patient transplantation of the sacral nerve was performed. In the second patient the nerve was released from ligatures, and in the third patient the nerve was first released from the cicatrice and the transposition of the tendon of the posterior tibial muscle followed. All three patients went through intensive rehabilitation. The first patient still wears peroneal splint, the limb is atrophic. In the second patient the function has been well restored and he is not disabled anymore. However, the restitution of the lower limb function is not sufficient for him to work as a teacher of physical education. The third patient still suffers from serious paresis of the peroneal nerve. CONCLUSIONS: Even a frequent and relatively simple intervention such as varicose vein surgery may be accompanied by serious complications affecting patients for the rest of their lives. Serious motor nerve injuries are encountered only in operations in the popliteal fossa and the fibula head. Complications are more frequent when operations are performed by young general surgeons than when they are performed by an experienced surgeon or an expert in vascular surgery. The affected patients should be referred for neurosurgery; however, results are unpredictable. In spite of an intensive rehabilitation and possible plastic surgery the patients are permanently affected.

• MeSH
• časové faktory MeSH
• dospělí MeSH
• klinické kompetence MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• nervus peroneus zranění   patofyziologie   chirurgie   MeSH
• neurochirurgické výkony MeSH
• neuropatie nervus peroneus etiologie   patofyziologie   rehabilitace   chirurgie   MeSH
• obnova funkce MeSH
• retrospektivní studie MeSH
• varixy chirurgie   MeSH
• vena saphena transplantace   MeSH
• výkony cévní chirurgie škodlivé účinky   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

PURPOSE OF THE STUDY The aim of the study was to assess the functional outcomes of rehabilitation in patients with surgically treated distal radius fractures in the early postoperative period. We compared the functional outcomes of patients undergoing standard rehabilitation with the group of patients whose postoperative rehabilitation was extended with shoulder girdle exercises of the affected upper limb while the wrist was immobilized. Several indices and variables were used for the assessment of the functional therapeutic outcomes of the affected wrist. MATERIAL AND METHODS Forty patients (32 females and 8 males, the mean age 60.5 years) with distal radius fractures treated by internal fixation using volar surgical approach were involved in the study between 2013-2016. The tested subjects were randomized and split into two groups according to the selected method of rehabilitation. The tested subjects with standard rehabilitation extended with shoulder girdle muscles activation were labelled as group I. It included patients (n = 20) of the mean age 59.8 (age range 42-73 years) with immobilized wrist (i.e. for 3-4 weeks) performing shoulder girdle muscles exercises at the same time. Furthermore, standard kinesiotherapy continued after their fixation was removed. The other tested group, labelled as group II (n = 20), the mean age 61.3 (variation 40-74 years of age) involved patients with distal radius fractures. Only standard rehabilitation was performed in this group as late as their forearm fixation was removed. The following indices and parameters were assessed in the early postoperative period (i.e. by 8 weeks after the fixation removal): wrist and fingers range of motion (ROM), hand grip strength (dynamometry), local swelling, pain, scores of a nine hole peg test (NHPT), and a DASH score. RESULTS After the fixation had been removed, the group I reported statistically significantly higher values of movement compared to the values of the contralateral limb in the following directions: dorsal flexion, palmar flexion, MP joints flexion, flexion of PIP joints (proximal interphalangeal), and flexion of DIP joints (distal interphalangeal). After eight weeks, the group I manifested significantly higher values in dorsal flexion, palmar flexion and ulnar deviation in the wrist. There were no significant differences in other movement directions. The hand grip strength mean value examined with a dynamometer was significantly higher in the group I in the sixth and eighth week of testing (group I - 58.9% strength of a healthy limb after six weeks, or 66.5% after eight weeks). The results in the group II were 49.9% strength of a healthy limb after six weeks, or 56.6% after eight weeks. The group I showed statistically significantly lower values of wrist swelling and higher finger dexterity in the NHPT in all measured weeks. Lower pain intensity in the group I during the measurements was observed. At the same time, this group showed significantly better results in the DASH score. DISCUSSION The results of this study are useful for clinical practice. They confirm a functional relation between the activity of hand muscles and the shoulder muscle activity. The differences in the functional ability of the hand and the functional state of the injured wrist were detected as early as in the early postoperative period. It could be stated that the tested subjects in the group I showed a greater and faster improvement in the physical function of the injured hand. This was also accompanied by a positive psychological effect. We had not found a study of a similar type in the available literature that we could have compared our submitted results to. CONCLUSIONS Shoulder girdle muscles exercises after a distal radius fracture, while wrist is immobilized, can evidently enhance functional capability and accelerate the hand-function restitution. Early functional outcomes of the injured wrist after the rehabilitation with shoulder girdle muscles exercises support the efficiency of this broadened rehabilitation protocol. Key words: distal radius frac,ture, hand, shoulder, functional treatment, rehabilitation.

• MeSH
• dospělí MeSH
• fraktury vřetenní kosti rehabilitace   chirurgie   MeSH
• imobilizace škodlivé účinky   metody   MeSH
• kosterní svaly * patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• rameno * patofyziologie   MeSH
• rozsah kloubních pohybů MeSH
• senioři MeSH
• síla ruky MeSH
• terapie cvičením metody   MeSH
• vnitřní fixace fraktury škodlivé účinky   metody   rehabilitace   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH

The histological and histochemical state of the thyroid gland of Oreochromis mossambicus was analyzed after 20 days' exposure of the fish to BHC (p less than 0.001 ppm). Histological changes after exposure included acolloidal and atrophied follicles and goitre formation. Follicular and nuclear diameter and the E/T ratio were significantly (p less than 0.001) higher than in the corresponding controls. The above insecticide led to thyroid dysfunction. The histochemical characteristics of the gland also changed after BHC treatment. When exposed fish were transferred to normal, clear, dechlorinated water, the altered follicles displayed remarkable recovery of activity and thyroid function returned to almost the same state as in normal controls. Histological and histochemical evaluation at 10-day intervals revealed healthy functional restitution of the gland, indicating that BHC-induced changes are reversible.

• MeSH
• barvení a značení MeSH
• hexachlorcyklohexan farmakologie   MeSH
• ryby anatomie a histologie   MeSH
• štítná žláza účinky léků   ultrastruktura   MeSH
• voda MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• hexachlorcyklohexan MeSH
• voda MeSH

BACKGROUND: Periampullary tumours (PAT) may cause obstruction of distal choledochus. The bile stasis is a risk factor for microbial colonisation of bile (bacteriobilia), cholangitis, hepatic insufficiency and coagulopathy. PAT obstruction can be managed surgically or non-operatively - by inserting a biliary drain or stent (BDS). Although BDS allows for adequate bile drainage, liver function restitution and coagulopathy, increased bacteriobilia has been reported and this is associated with an increased incidence of postoperative complications. METHODS: A monocentric, prospective, comparative study including 100 patients operated with PAT. The effects of bacteriobilia and the presence of a drain in the biliary tract on the development of postoperative complications were evaluated. RESULTS: Positive microbial findings in bile were found in 67% of patients. It was 98% in the biliary drain group vs. 36% in non-drained patients (p = 0.0001). In 68% 2 or more different bacterial strains were simultaneously present (p = 0.0001). Patients with a positive microbial finding in bile had more frequent incidence of infectious complications 40.2% (27) vs. 9.1% (3); p = 0.0011. The most frequent infectious complication was wound infection 29.8% (20) vs. 3.03% (1); p = 0.0014. Similarly, a higher incidence of postoperative infectious complications occurred in patients with BDS - 36% (18) vs. 24% (12); p = 0.2752. CONCLUSION: The presence of a drain or stent in the biliary tract significantly increases the microbial colonisation of bile. It is associated with a significant increase in infectious complications, especially infections in the wound.

• Klíčová slova
• Bacteriobilia, Complications, Periampullary tumor,
• MeSH
• cholangitida * epidemiologie   etiologie   chirurgie   MeSH
• cholestáza * MeSH
• lidé MeSH
• nádory * MeSH
• pooperační komplikace epidemiologie   etiologie   MeSH
• prospektivní studie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH