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The inflammatory radicular cysts have higher concentration of TNF-? in comparison to odontogenic keratocysts (odontogenic tumour)
Vladimir Jurisic, Snjezana Colic, Milan Jurisic
Jazyk angličtina Země Česko
Digitální knihovna NLK
Plný text - Článek
Číslo
Ročník
Zdroj
Zdroj
NLK
Directory of Open Access Journals
od 1997
Free Medical Journals
od 1997
Open Access Digital Library
od 1997-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1997
- MeSH
- cysty etiologie chirurgie imunologie MeSH
- ELISA využití MeSH
- financování organizované MeSH
- histologie MeSH
- lidé MeSH
- odontogenní cysty etiologie chirurgie imunologie MeSH
- odontogenní nádory etiologie chirurgie imunologie MeSH
- radikulopatie etiologie chirurgie imunologie MeSH
- TNF-alfa izolace a purifikace MeSH
- Check Tag
- lidé MeSH
TNF-? is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-? in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-? is elevated in both cysts’ fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-? was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p<0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-?. We here for the first time present that a difference in the concentration of TNF-? exists between these two cystic types. Key words: TNF; Radicular cysts; Odontogenic tumour; Surgery; Cyst size; Hystology
Citace poskytuje Crossref.org
Lit.: 26
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