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Transient hyperphosphatasemia in pediatric renal transplant patients--is there a need for concern and when?
S. Kutílek, S. Skálová, J. Vethamuthu, P. Geier, J. Feber,
Jazyk angličtina Země Dánsko
Typ dokumentu kazuistiky, časopisecké články
NLK
Medline Complete (EBSCOhost)
od 1999-01-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1999-01-01 do 2012-12-31
- MeSH
- alkalická fosfatasa krev MeSH
- biopsie MeSH
- dítě MeSH
- hyperfosfatemie etiologie terapie MeSH
- kosti a kostní tkáň patologie MeSH
- lidé MeSH
- nefrotický syndrom terapie MeSH
- předškolní dítě MeSH
- protein - isoformy MeSH
- renální insuficience terapie MeSH
- transplantace ledvin metody MeSH
- výsledek terapie MeSH
- zápěstí radiografie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
TH of infancy and early childhood is characterized by transiently increased S-ALP, predominantly its bone or liver isoforms. There are neither signs of metabolic bone disease or hepatopathy corresponding to the increased S-ALP, nor a common underlying/triggering disease. TH may also occur in children post-renal Tx, which may raise significant concerns and anxiety. We describe four patients aged 2.8-7 yr in whom the TH occurred at 11-34 (median = 28) months after Tx and lasted from 40 to 105 (median = 63) days. No obvious cause/trigger of TH could be found; the clinical status and bone turnover were not altered. In cases of TH post-Tx, we recommend the evaluation of basic biochemical indices and wrist X-ray. If these results are normal, TH is most likely the diagnosis and the S-ALP can be monitored over the next three months without further testing. In patients with persisting TH for more than three months and/or in children with pre-existing or suspected metabolic bone disease, further evaluation may be indicated. In conclusion, TH is a benign disorder in patients post-Tx. Detailed investigation including bone biopsy is only indicated in patients with persisting TH.
Citace poskytuje Crossref.org
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- $a Transient hyperphosphatasemia in pediatric renal transplant patients--is there a need for concern and when? / $c S. Kutílek, S. Skálová, J. Vethamuthu, P. Geier, J. Feber,
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- $a TH of infancy and early childhood is characterized by transiently increased S-ALP, predominantly its bone or liver isoforms. There are neither signs of metabolic bone disease or hepatopathy corresponding to the increased S-ALP, nor a common underlying/triggering disease. TH may also occur in children post-renal Tx, which may raise significant concerns and anxiety. We describe four patients aged 2.8-7 yr in whom the TH occurred at 11-34 (median = 28) months after Tx and lasted from 40 to 105 (median = 63) days. No obvious cause/trigger of TH could be found; the clinical status and bone turnover were not altered. In cases of TH post-Tx, we recommend the evaluation of basic biochemical indices and wrist X-ray. If these results are normal, TH is most likely the diagnosis and the S-ALP can be monitored over the next three months without further testing. In patients with persisting TH for more than three months and/or in children with pre-existing or suspected metabolic bone disease, further evaluation may be indicated. In conclusion, TH is a benign disorder in patients post-Tx. Detailed investigation including bone biopsy is only indicated in patients with persisting TH.
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