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Quantiferon-CMV test in prediction of cytomegalovirus infection after kidney transplantation
A. Lochmanova, I. Lochman, H. Tomaskova, P. Marsalkova, J. Raszka, J. Mrazek, J. Dedochova, A. Martinek, H. Brozmanova, M. Grundmann
Jazyk angličtina Země Spojené státy americké
Typ dokumentu hodnotící studie, časopisecké články
Grantová podpora
1A8655
MZ0
CEP - Centrální evidence projektů
- MeSH
- buněčná imunita MeSH
- CD8-pozitivní T-lymfocyty imunologie virologie MeSH
- cytomegalovirové infekce diagnóza etiologie imunologie MeSH
- Cytomegalovirus genetika imunologie MeSH
- DNA virů krev MeSH
- dospělí MeSH
- ELISA MeSH
- hodnocení rizik MeSH
- imunosupresiva škodlivé účinky MeSH
- interferon gama krev MeSH
- latence viru MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- mladý dospělý MeSH
- prediktivní hodnota testů MeSH
- prospektivní studie MeSH
- protilátky virové krev MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- transplantace ledvin škodlivé účinky MeSH
- virová nálož MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- Geografické názvy
- Česká republika MeSH
Infection with cytomegalovirus (CMV) is a major cause of morbidity and mortality in immunosuppressed patients, including organ and bone marrow transplant recipients. The majority of CMV disease is caused by reactivation of alatent infection rather that by newly acquired virus. Many techniques have been currently available to aid in the diagnostics of CMV disease. In this report we performed a prospective evaluation of Quantiferon-CMV assay (Cellestis) to determine whether the test is predictive of CMV disease. CD8+ T-cell CMV-specific immunity was assessed in a longitudinal cohort of 14 kidney transplant recipients. According to our data, subjects with higher cellular immune response measured with Quantiferon test had a lower risk of manifestation of CMV infection than subjects with lower responses. Despite the small number of patients and large intra- and interindividual variability of the data in the study, we observed the Quantiferon-CMV assay to be a sensitive specific test to detect a virus-specific T-cell response. We propose that this assay in combination with viral DNA load estimates may prove to be useful to stratify patients at risk of CMV disease.
Citace poskytuje Crossref.org
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- $a Lochmanová, Alexandra $u Department of Immunology and Allergy, Institute of Public Health, Partyzanske nam. 7, Ostrava 702 00, Czech Republic. alexandra.lochmanova@zuova.cz $7 ola2006340321
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- $a Infection with cytomegalovirus (CMV) is a major cause of morbidity and mortality in immunosuppressed patients, including organ and bone marrow transplant recipients. The majority of CMV disease is caused by reactivation of alatent infection rather that by newly acquired virus. Many techniques have been currently available to aid in the diagnostics of CMV disease. In this report we performed a prospective evaluation of Quantiferon-CMV assay (Cellestis) to determine whether the test is predictive of CMV disease. CD8+ T-cell CMV-specific immunity was assessed in a longitudinal cohort of 14 kidney transplant recipients. According to our data, subjects with higher cellular immune response measured with Quantiferon test had a lower risk of manifestation of CMV infection than subjects with lower responses. Despite the small number of patients and large intra- and interindividual variability of the data in the study, we observed the Quantiferon-CMV assay to be a sensitive specific test to detect a virus-specific T-cell response. We propose that this assay in combination with viral DNA load estimates may prove to be useful to stratify patients at risk of CMV disease.
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- $a Mrázek, Jakub $7 xx0071423 $u School of Dairy Industry and Higher Vocational School of Food Technology in Kroměříž, Štěchovice 1358, 767 54, Kroměříž, Czech Republic; Department of Food Technology, Faculty of Technology, Tomas Bata University in Zlín, nám. T. G. Masaryka, 5555, Zlín, Czech Republic
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- $a Grundmann, Milan, $d 1939- $7 nlk20010093222 $u Department of Clinical Pharmacology, Ostrava University Hospital and Faculty of Health Studies, University of Ostrava, 708 52 Ostrava, Czech Republic. milan.grundmann@fnspo.cz
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