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Microcephalin guards against small brains, genetic instability, and cancer
J Bartek
Jazyk angličtina Země Spojené státy americké
NLK
Cell Press Free Archives
od 2002-02-01 do Před 1 rokem
Free Medical Journals
od 2002 do Před 1 rokem
ScienceDirect (archiv)
od 2002-01-01 do 2008-12-31
PubMed
16904606
Knihovny.cz E-zdroje
- MeSH
- buněčný cyklus * fyziologie MeSH
- chromozomální aberace MeSH
- lidé MeSH
- mitóza fyziologie MeSH
- mozek * abnormality MeSH
- mutace MeSH
- nádorové supresorové proteiny fyziologie genetika MeSH
- nádory genetika metabolismus patologie MeSH
- nestabilita genomu * fyziologie MeSH
- poškození DNA fyziologie MeSH
- proteiny nervové tkáně fyziologie genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
Through its roles in cell cycle control and DNA damage response, microcephalin (also known as BRIT1 or MCPH1) has been implicated in fundamental biological processes, including regulation of brain size and maintenance of genomic integrity. Two new reports in Nature Cell Biology and this issue of Cancer Cell provide further insights into the functions of microcephalin in DNA damage checkpoints and timing of mitosis. Depletion or disease-associated mutations of microcephalin resulted in centrosomal abnormalities and chromosomal instability. These findings and aberrantly reduced expression in human carcinomas identify microcephalin as a candidate novel tumor suppressor.
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