-
Je něco špatně v tomto záznamu ?
Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: a retrospective multicenter cohort study
A. Zaal, RP. Zweemer, M. Zikán, L. Dusek, D. Querleu, F. Lécuru, AS. Bats, R. Jach, L. Sevcik, P. Graf, J. Klát, G. Dyduch, S. von Mensdorff-Pouilly, GG. Kenter, RH. Verheijen, D. Cibula,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie
NLK
ProQuest Central
od 2013-01-01 do 2014-12-31
Health & Medicine (ProQuest)
od 2013-01-01 do 2014-12-31
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfadenektomie * MeSH
- lymfatické uzliny patologie MeSH
- nádory děložního čípku patologie chirurgie MeSH
- pánev patologie chirurgie MeSH
- přežití MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
OBJECTIVE: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. METHODS: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study. Radioisotope tracers and blue dye were used to localize the sentinel node, and pathologic ultrastaging was performed. RESULTS: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survival was significantly better (P = 0.046) if more than 16 non-SNs were removed. No such significant difference in survival was detected in patients with negative or macrometastatic sentinel nodes. CONCLUSIONS: Our findings indicate that in patients with negative or macrometastatic disease in the sentinel nodes, an additional LND did not alter survival. Conversely, our data suggest that the survival of patients with low-volume disease is improved when more than 16 additional lymph nodes are removed. If in a prospective trial our data are confirmed, we would suggest a 2-stage operation.
§Institut Claudius Regaud Toulouse
¶Jagiellonian University Medical College Krakow Poland
**Center for Gynaecologic Oncology Amsterdam VU University Medical Center Amsterdam The Netherlands
‡Institute of Biostatistics and Analyses Masaryk University Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15008409
- 003
- CZ-PrNML
- 005
- 20160613092858.0
- 007
- ta
- 008
- 150306s2014 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/IGC.0000000000000043 $2 doi
- 035 __
- $a (PubMed)24407577
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Zaal, Afra $u *Division of Woman and Baby, Department of Gynaecological Oncology, University Medical Center Utrecht, Utrecht, The Netherlands; †Department of Obstetrics and Gynecology, Gynecological Oncology Centre, First Faculty of Medicine and General University Hospital, Charles University, Prague; ‡Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic; §Institut Claudius Regaud, Toulouse; ∥Université Paris Descartes, Sorbonne Paris Cité, Assistance Publique-Hôpitaux de Paris, European Georges-Pompidou Teaching Hospital, Paris, France; ¶Jagiellonian University Medical College, Krakow, Poland; #University Hospital Ostrava, Ostrava, Czech Republic; and **Center for Gynaecologic Oncology Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
- 245 10
- $a Pelvic lymphadenectomy improves survival in patients with cervical cancer with low-volume disease in the sentinel node: a retrospective multicenter cohort study / $c A. Zaal, RP. Zweemer, M. Zikán, L. Dusek, D. Querleu, F. Lécuru, AS. Bats, R. Jach, L. Sevcik, P. Graf, J. Klát, G. Dyduch, S. von Mensdorff-Pouilly, GG. Kenter, RH. Verheijen, D. Cibula,
- 520 9_
- $a OBJECTIVE: In this study, we aimed to describe the value of pelvic lymph node dissection (LND) after sentinel lymph node (SN) biopsy in early-stage cervical cancer. METHODS: We performed a retrospective multicenter cohort study in 8 gynecological oncology departments. In total, 645 women with International Federation of Gynecology and Obstetrics stage IA to IIB cervical cancer of squamous, adeno, or adenosquamous histologic type who underwent SN biopsy followed by pelvic LND were enrolled in this study. Radioisotope tracers and blue dye were used to localize the sentinel node, and pathologic ultrastaging was performed. RESULTS: Among the patients with low-volume disease (micrometastases and isolated tumor cells) in the sentinel node, the overall survival was significantly better (P = 0.046) if more than 16 non-SNs were removed. No such significant difference in survival was detected in patients with negative or macrometastatic sentinel nodes. CONCLUSIONS: Our findings indicate that in patients with negative or macrometastatic disease in the sentinel nodes, an additional LND did not alter survival. Conversely, our data suggest that the survival of patients with low-volume disease is improved when more than 16 additional lymph nodes are removed. If in a prospective trial our data are confirmed, we would suggest a 2-stage operation.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a lymfadenektomie $7 D008197
- 650 _2
- $a lymfatické uzliny $x patologie $7 D008198
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a pánev $x patologie $x chirurgie $7 D010388
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a přežití $7 D013534
- 650 _2
- $a nádory děložního čípku $x patologie $x chirurgie $7 D002583
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Zweemer, Ronald P
- 700 1_
- $a Zikán, Michal
- 700 1_
- $a Dusek, Ladislav
- 700 1_
- $a Querleu, Denis
- 700 1_
- $a Lécuru, Fabrice
- 700 1_
- $a Bats, Anne-Sophie
- 700 1_
- $a Jach, Robert
- 700 1_
- $a Sevcik, Libor
- 700 1_
- $a Graf, Petar
- 700 1_
- $a Klát, Jaroslav $7 osd2016913393
- 700 1_
- $a Dyduch, Grzegorz
- 700 1_
- $a von Mensdorff-Pouilly, Silvia
- 700 1_
- $a Kenter, Gemma G
- 700 1_
- $a Verheijen, René H M
- 700 1_
- $a Cibula, David
- 773 0_
- $w MED00009896 $t International journal of gynecological cancer official journal of the International Gynecological Cancer Society $x 1525-1438 $g Roč. 24, č. 2 (2014), s. 303-11
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/24407577 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150306 $b ABA008
- 991 __
- $a 20160613093028 $b ABA008
- 999 __
- $a ok $b bmc $g 1065682 $s 891209
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 24 $c 2 $d 303-11 $i 1525-1438 $m International journal of gynecological cancer $n Int J Gynecol Cancer $x MED00009896
- LZP __
- $a Pubmed-20150306
