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Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis
S. Banerjee, Y. Resch, KW. Chen, I. Swoboda, M. Focke-Tejkl, K. Blatt, N. Novak, M. Wickman, M. van Hage, R. Ferrara, A. Mari, A. Purohit, G. Pauli, EN. Sibanda, P. Ndlovu, WR. Thomas, V. Krzyzanek, S. Tacke, U. Malkus, P. Valent, R. Valenta, S. Vrtala,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1938 do Před 1 rokem
Freely Accessible Science Journals
od 1938 do Před 1 rokem
ProQuest Central
od 2000-01-01 do 2015-12-31
Open Access Digital Library
od 1938-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do 2015-12-31
PubMed
24999597
DOI
10.1038/jid.2014.271
Knihovny.cz E-zdroje
- MeSH
- antigeny roztočů domácího prachu chemie genetika imunologie MeSH
- atopická dermatitida epidemiologie imunologie MeSH
- biologické markery MeSH
- cirkulární dichroismus MeSH
- Dermatophagoides pteronyssinus genetika imunologie MeSH
- dítě MeSH
- dospělí MeSH
- imunoglobulin E krev imunologie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- molekulární sekvence - údaje MeSH
- proteiny členovců MeSH
- protilátky krev imunologie MeSH
- sekundární struktura proteinů MeSH
- sekvence aminokyselin MeSH
- séroepidemiologické studie MeSH
- tropomyosin chemie genetika imunologie MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.
Center for Molecular Allergology IDI IRCCS Rome Italy
Christian Doppler Laboratory for Allergy Research Medical University of Vienna Vienna Austria
Department of Dermatology and Allergy University of Bonn Bonn Germany
Gamma City Laboratory Harare Zimbabwe
Institute of Medical Physics and Biophysics University of Münster Münster Germany
Institute of Scientific Instruments Academy of Sciences of the Czech Republic Brno Czech Republic
Service de Pneumologie Hôpitaux Universitaires de Strasbourg Strasbourg France
Citace poskytuje Crossref.org
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- $a House dust mites (HDMs) belong to the most potent indoor allergen sources worldwide and are associated with allergic manifestations in the respiratory tract and the skin. Here we studied the importance of the high-molecular-weight group 11 allergen from Dermatophagoides pteronyssinus (Der p 11) in HDM allergy. Sequence analysis showed that Der p 11 has high homology to paramyosins from mites, ticks, and other invertebrates. A synthetic gene coding for Der p 11 was expressed in Escherichia coli and rDer p 11 purified to homogeneity as folded, alpha-helical protein as determined by circular dichroism spectroscopy. Using antibodies raised against rDer p 11 and immunogold electron microscopy, the allergen was localized in the muscle beneath the skin of mite bodies but not in feces. IgE reactivity of rDer p 11 was tested with sera from HDM-allergic patients from Europe and Africa in radioallergosorbent test-based dot-blot assays. Interestingly, we found that Der p 11 is a major allergen for patients suffering from atopic dermatitis (AD), whereas it is only a minor allergen for patients suffering from respiratory forms of HDM allergy. Thus, rDer p 11 might be a useful serological marker allergen for the identification of a subgroup of HDM-allergic patients suffering from HDM-associated AD.
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