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FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations
K. Storey, S. Johanidesová, R. Matěj, J. Keller, Z. Rohan, R. Rusina,
Jazyk angličtina Země Velká Británie
Typ dokumentu kazuistiky, časopisecké články
- MeSH
- DNA vazebné proteiny metabolismus MeSH
- frontotemporální demence komplikace patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozek diagnostické zobrazování metabolismus MeSH
- neuropsychologické testy MeSH
- progresivní supranukleární obrna komplikace diagnostické zobrazování patologie MeSH
- ubikvitin metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
Frontotemporal lobar degeneration with transactive response DNA-binding protein 43 (FTLD-TDP) and progressive supranuclear palsy (PSP) are distinct neurodegenerations with different clinical presentations. We report two cases with FTLD-TDP and PSP in comorbidity: a patient with amnestic dementia developing frontal lobe dementia, Parkinsonism and supranuclear gaze palsy and a patient with cerebellar ataxia and nystagmus developing akinesia, rigidity, and subcortical dementia. Neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-TDP-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. Clinical and neuropathological correlations in atypical neurodegenerations are crucial to describe new entities of overlapping syndromes.
Citace poskytuje Crossref.org
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- $a Rusina, Robert $u a Department of Neurology , Thomayer Hospital , Prague , Czech Republic. d Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine , Charles University, and General University Hospital , Prague , Czech Republic.
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