Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

M. Handl, M. Hermanova, S. Hotarkova, J. Jarkovsky, P. Mudry, T. Shatokhina, M. Vesela, J. Sterba, I. Zambo

. 2018 ; 162 (1) : 54-60. [pub] 20171121

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18032333

AIMS: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in Ewing sarcoma and to determine the correlation between TAMs and clinicopathological parameters. METHODS: Using immunohistochemistry, the expressions of CD68 and CD163 were examined in 24 tissue samples of Ewing sarcoma of bone. The density of CD68 and CD163-positive TAMs was analyzed quantitatively and semi-quantitatively and statistically correlated with clinical parameters. RESULTS: CD163-positive TAMs outnumbered CD68-positive cells (median of 130 vs 96, respectively). No statistically significant relatio nship was found between density of CD68-positive cells, clinical parameters or prognosis. However, high levels of CD163-positive TAMs were associated with localized disease (P=0.008). In cases with a higher density of CD163-positive cells, a trend toward longer survival was revealed (P=0.063). CONCLUSION: This is the first study that has quantified CD163 expression in TAMs in Ewing sarcoma and showed its possible prognostic value. CD163 was confirmed to be a more specific marker of macrophages than CD68. CD163 is not an exclusive hallmark of M2 macrophages.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18032333
003      
CZ-PrNML
005      
20181017150124.0
007      
ta
008      
181001s2018 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2017.049 $2 doi
035    __
$a (PubMed)29170560
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Handl, Marek $u Faculty of Medicine, Masaryk University, Brno, Czech Republic $7 xx0275561
245    10
$a Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma / $c M. Handl, M. Hermanova, S. Hotarkova, J. Jarkovsky, P. Mudry, T. Shatokhina, M. Vesela, J. Sterba, I. Zambo
520    9_
$a AIMS: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in Ewing sarcoma and to determine the correlation between TAMs and clinicopathological parameters. METHODS: Using immunohistochemistry, the expressions of CD68 and CD163 were examined in 24 tissue samples of Ewing sarcoma of bone. The density of CD68 and CD163-positive TAMs was analyzed quantitatively and semi-quantitatively and statistically correlated with clinical parameters. RESULTS: CD163-positive TAMs outnumbered CD68-positive cells (median of 130 vs 96, respectively). No statistically significant relatio nship was found between density of CD68-positive cells, clinical parameters or prognosis. However, high levels of CD163-positive TAMs were associated with localized disease (P=0.008). In cases with a higher density of CD163-positive cells, a trend toward longer survival was revealed (P=0.063). CONCLUSION: This is the first study that has quantified CD163 expression in TAMs in Ewing sarcoma and showed its possible prognostic value. CD163 was confirmed to be a more specific marker of macrophages than CD68. CD163 is not an exclusive hallmark of M2 macrophages.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a CD antigeny $x fyziologie $7 D015703
650    _2
$a antigeny diferenciační myelomonocytární $x fyziologie $7 D015214
650    _2
$a nádorové buněčné linie $x metabolismus $7 D045744
650    _2
$a proliferace buněk $x fyziologie $7 D049109
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a makrofágy $x metabolismus $7 D008264
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a pilotní projekty $7 D010865
650    _2
$a receptory buněčného povrchu $x fyziologie $7 D011956
650    _2
$a Ewingův sarkom $x patologie $7 D012512
650    _2
$a nádorové mikroprostředí $7 D059016
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hermanová, Markéta, $u 1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University, Brno and St. Anne's University Hospital, Brno, Czech Republic $d 1969- $7 xx0073982
700    1_
$a Hotárková, Sylva $u 1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University, Brno and St. Anne's University Hospital, Brno, Czech Republic $7 xx0228356
700    1_
$a Jarkovský, Jiří $u Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic $7 stk2008461294
700    1_
$a Múdry, Peter $u Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $7 xx0153990
700    1_
$a Shatokhina, Tetiana $u 1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University, Brno and St. Anne's University Hospital, Brno, Czech Republic
700    1_
$a Veselá, Marcela $u 1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University, Brno and St. Anne's University Hospital, Brno, Czech Republic $7 xx0228367
700    1_
$a Štěrba, Jaroslav, $u Department of Pediatric Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic $d 1962- $7 mzk2004237310
700    1_
$a Zambo, Iva $u 1st Department of Pathological Anatomy, Faculty of Medicine, Masaryk University, Brno and St. Anne's University Hospital, Brno, Czech Republic $7 xx0211296
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 162, č. 1 (2018), s. 54-60
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29170560 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20181001 $b ABA008
991    __
$a 20181016090956 $b ABA008
999    __
$a ok $b bmc $g 1343538 $s 1029324
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 162 $c 1 $d 54-60 $e 20171121 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20181001

Najít záznam

Citační ukazatele

Možnosti archivace