Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Elevated age-related cortical iron, ferritin and amyloid plaques in APP(swe)/PS1(deltaE9) transgenic mouse model of Alzheimer's disease

H. Svobodová, D. Kosnáč, Z. Balázsiová, H. Tanila, P. O. Miettinen, A. Sierra, P. Vitovič, A. Wagner, Š. Polák, M. Kopáni

. 2019 ; 68 (Suppl 4) : S445-S451. [pub] 20191230
. 2019 ; () : S445-S451.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc21028206

Iron is very important element for functioning of the brain. Its concentration changes with aging the brain or during disease. The aim of our work was the histological examination of content of ferritin and free iron (unbound) in brain cortex in association with Abeta plaques from their earliest stages of accumulation in amyloid plaque forming APP/PS1 transgenic mice. Light microscopy revealed the onset of plaques formation at 8-monthage. Detectable traces of free iron and no ferritin were found around plaques at this age, while the rate of their accumulation in and around Abeta plaques was elevated at 13 months of age. Ferritin accumulated mainly on the edge of Abeta plaques, while the smaller amount of free iron was observed in the plaque-free tissue, as well as in and around Abeta plaques. We conclude that free iron and ferritin accumulation follows the amyloid plaques formation. Quantification of cortical iron and ferritin content can be an important marker in the diagnosis of Alzheimer's disease.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc21028206
003      
CZ-PrNML
005      
20220325111236.0
007      
ta
008      
211105s2019 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934383 $2 doi
035    __
$a (PubMed)32118475
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Svobodová, Helena, $d 1990- $7 xx0267736 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine and Department of simulation and virtual medical education, Comenius University, Faculty of medicine, Bratislava, Slovakia $u Department of Simulation and Virtual Education, Comenius University, Faculty of Medicine, Bratislava, Slovakia
245    10
$a Elevated age-related cortical iron, ferritin and amyloid plaques in APP(swe)/PS1(deltaE9) transgenic mouse model of Alzheimer's disease / $c H. Svobodová, D. Kosnáč, Z. Balázsiová, H. Tanila, P. O. Miettinen, A. Sierra, P. Vitovič, A. Wagner, Š. Polák, M. Kopáni
504    __
$a Literatura
520    9_
$a Iron is very important element for functioning of the brain. Its concentration changes with aging the brain or during disease. The aim of our work was the histological examination of content of ferritin and free iron (unbound) in brain cortex in association with Abeta plaques from their earliest stages of accumulation in amyloid plaque forming APP/PS1 transgenic mice. Light microscopy revealed the onset of plaques formation at 8-monthage. Detectable traces of free iron and no ferritin were found around plaques at this age, while the rate of their accumulation in and around Abeta plaques was elevated at 13 months of age. Ferritin accumulated mainly on the edge of Abeta plaques, while the smaller amount of free iron was observed in the plaque-free tissue, as well as in and around Abeta plaques. We conclude that free iron and ferritin accumulation follows the amyloid plaques formation. Quantification of cortical iron and ferritin content can be an important marker in the diagnosis of Alzheimer's disease.
650    _2
$a Alzheimerova nemoc $x metabolismus $7 D000544
650    _2
$a zvířata $7 D000818
650    _2
$a mozková kůra $x metabolismus $7 D002540
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a ferritiny $x metabolismus $7 D005293
650    _2
$a železo $x metabolismus $7 D007501
650    _2
$a myši transgenní $7 D008822
650    _2
$a amyloidní plaky $x metabolismus $7 D058225
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kosnáč, Daniel, $d 1990- $7 xx0267737 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Comenius University, Faculty of Medicine, Bratislava, Slovakia $u Department of Simulation and Virtual Education, Comenius University, Faculty of Medicine, Bratislava, Slovakia
700    1_
$a Balázsiová, Zuzana $7 xx0133259 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Comenius University, Faculty of Medicine, Bratislava, Slovakia
700    1_
$a Tanila, H.
700    1_
$a Miettinen, P. O.
700    1_
$a Sierra, A.
700    1_
$a Vitovič, Pavol, $d 1978- $7 xx0267746 $u Department of Simulation and Virtual Education, Comenius University, Faculty of Medicine, Bratislava, Slovakia
700    1_
$a Wagnerová, Alexandra, $d 1984- $7 xx0267747 $u Department of Simulation and Virtual Education, Comenius University, Faculty of Medicine, Bratislava, Slovakia
700    1_
$a Polák, Štefan $7 uk2007408813 $u Institute of Histology and Embryology, Comenius University, Faculty of Medicine, Bratislava, Slovakia
700    1_
$a Kopáni, Martin $7 xx0078268 $u Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Comenius University, Faculty of Medicine, Bratislava, Slovakia
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, Suppl 4 (2019), s. S445-S451
773    0_
$t Contemporary Czech and Slovak research on medical biophysics $g (2019), s. S445-S451 $w MED00208906
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32118475 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20211105 $b ABA008
991    __
$a 20220325111228 $b ABA008
999    __
$a ok $b bmc $g 1735526 $s 1148751
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c Suppl 4 $d S445-S451 $e 20191230 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
BMC    __
$a 2019 $d S445-S451 $m Contemporary Czech and Slovak research on medical biophysics $x MED00208906
LZP    __
$b NLK118 $a Pubmed-20211105

Najít záznam

Citační ukazatele

Možnosti archivace