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Premotor Parkinson's disease: Overview of clinical symptoms and current diagnostic methods

M. Kaiserova, Z. Grambalova, S. Kurcova, P. Otruba, H. Prikrylova Vranova, K. Mensikova, P. Kanovsky

. 2021 ; 165 (2) : 103-112. [pub] 20210204

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22007867

Parkinson's disease (PD) is characterized by typical motor symptoms. However, recent studies show several non-motor features that may precede the development of the motor symptoms of PD. The best known premotor symptoms include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. In this review, we summarize currently available diagnostic methods for these symptoms. We also briefly summarize neuroimaging, polyneuropathy, peripheral markers, and cerebrospinal fluid biomarkers that may be used in the early diagnosis of PD.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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