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Validation of the 'Inflammatory Bowel Disease-Distribution, Chronicity, Activity [IBD-DCA] Score' for Ulcerative Colitis and Crohn ́s Disease
C. Lang-Schwarz, M. Angeloni, A. Agaimy, R. Atreya, C. Becker, T. Dregelies, S. Danese, JF. Fléjou, N. Gaßler, HI. Grabsch, A. Hartmann, K. Kamarádová, AA. Kühl, GY. Lauwers, A. Lugli, I. Nagtegaal, MF. Neurath, G. Oberhuber, L. Peyrin-Biroulet,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, validační studie
Grantová podpora
TRR241
Deutsche Forschungsgemeinschaft
PubMed
33773497
DOI
10.1093/ecco-jcc/jjab055
Knihovny.cz E-zdroje
- MeSH
- biopsie MeSH
- Crohnova nemoc patologie MeSH
- lidé MeSH
- reprodukovatelnost výsledků MeSH
- střevní sliznice patologie MeSH
- stupeň závažnosti nemoci * MeSH
- ulcerózní kolitida patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- validační studie MeSH
BACKGROUND AND AIMS: Histological scoring plays a key role in the assessment of disease activity in ulcerative colitis [UC] and is also important in Crohn ́s disease [CD]. Currently, there is no common scoring available for UC and CD. We aimed to validate the Inflammatory Bowel Disease [IBD]-Distribution [D], Chronicity [C], Activity [A] score [IBD-DCA score] for histological disease activity assessment in IBD. METHODS: Inter- and intra-rater reliability were assessed by 16 observers on biopsy specimens from 59 patients with UC and 25 patients with CD. Construct validity and responsiveness to treatment were retrospectively evaluated in a second cohort of 30 patients. RESULTS: Inter-rater reliability was moderate to good for the UC cohort (intraclass correlation coefficients [ICCs] = 0.645, 0.623, 0.767 for D, C, and A, respectively) and at best moderate for the CD cohort [ICC = 0.690, 0.303, 0.733 for D, C, and A, respectively]. Intra-rater agreement ranged from good to excellent in both cohorts. Correlation with the Nancy Histological Index [NHI] was moderate and strong with the Simplified Geboes Score [SGS] and a Visual Analogue Scale [VAS], respectively. Large effect sizes were obtained for all three parameters. External responsiveness analysis revealed correlated changes between IBD-DCA score and NHI, SGS and VAS. CONCLUSIONS: The IBD-DCA score is a simple histological activity score for UC and CD, agreed and validated by a large group of IBD specialists. It provides reliable information on treatment response. Therefore, it has potential value for use in routine diagnostics as well as clinical studies.
Department of Gastroenterology Humanitas Research Hospital Rozzano Milan Italy
Department of Gastroenterology Nancy University Hospital Lorraine University Vandoeuvre France
Department of Pathology Karolinska Institute and University Hospital Stockholm Sweden
Department of Pathology Moffitt Cancer Center Tampa FL USA
Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands
Department of Pathology Spedali Civili Brescia Brescia Italy
Department of Pathology University of Michigan Ann Arbor MI USA
Institute for Legal Medicine Section Pathology University Hospital Jena Germany
Institute of Pathology Friedrich Alexander University Erlangen Germany
Institute of Pathology Klinikum Bayreuth GmbH Bayreuth Germany
Institute of Pathology Patho im Zentrum St Pölten Austria
Institute of Pathology Tirol Kliniken Innsbruck Austria
Institute of Pathology University of Bern Bern Switzerland
Pathology and Laboratory Medicine Mount Sinai Hospital University of Toronto Toronto ON Canada
Pathology Department Saint Antoine Hospital Pierre et Marie Curie University Paris France
Citace poskytuje Crossref.org
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