Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Hematological prognosticators in metastatic renal cell cancer treated with immune checkpoint inhibitors: a meta-analysis

T. Yanagisawa, K. Mori, S. Katayama, H. Mostafaei, F. Quhal, E. Laukhtina, P. Rajwa, RS. Motlagh, A. Aydh, F. König, NC. Grossmann, B. Pradere, J. Miki, M. Schmidinger, S. Egawa, SF. Shariat

. 2022 ; 14 (9) : 709-725. [pub] 20220425

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, metaanalýza, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018179

Aim: We aimed to assess the prognostic value of pretreatment hematological biomarkers in patients with metastatic renal cell carcinoma (mRCC) treated with immune checkpoint inhibitors (ICIs). Methods: PubMed, Web of Science and Scopus databases were searched for articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: Fifteen studies comprising 1530 patients were eligible for meta-analysis. High levels of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein and lactate dehydrogenase were significantly associated with worse progression-free survival. High NLR and PLR were significantly associated with worse overall survival. Conclusion: High pretreatment NLR and PLR appear to be hematological prognostic factors of progression and overall mortality in mRCC patients treated with ICIs. These findings might help in the design of correlative biomarker studies to guide the clinical decision-making in the immune checkpoint inhibitor era.

Department of Medicine 1 and Comprehensive Cancer Center Clinical Division of Oncology Medical University of Vienna Vienna 1090 Austria

Department of Urology 2nd Faculty of Medicine Charles University Prague 11638 Czech Republic

Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna 1090 Austria

Department of Urology King Fahad Specialist Hospital Dammam 32253 Saudi Arabia

Department of Urology King Faisal Medical City Abha 614312 Saudi Arabia

Department of Urology Luzerner Kantonsspital Lucerne 6004 Switzerland

Department of Urology Medical University of Silesia Zabrze 41 808 Poland

Department of Urology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700 8558 Japan

Department of Urology The Jikei University School of Medicine Tokyo105 8461 Japan

Department of Urology University Hospital Zurich Zurich 8091 Switzerland

Department of Urology University Medical Centre Hamburg Eppendorf Hamburg 20251 Germany

Department of Urology University of Texas Southwestern Medical Center Dallas TX 75390 USA

Department of Urology Weill Cornell Medical College New York NY 10021 USA

Division of Urology Hourani Center for Applied Scientific Research Al Ahliyya Amman University Amman 19328 Jordan

Institute for Urology and Reproductive Health Sechenov University Moscow 119991 Russia

Karl Landsteiner Institute of Urology and Andrology Vienna 1010 Austria

Men's Health and Reproductive Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

Research Center for Evidence Based Medicine Tabriz University of Medical Sciences Tabriz 5166 Iran

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22018179
003      
CZ-PrNML
005      
20220804134614.0
007      
ta
008      
220720s2022 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.2217/imt-2021-0207 $2 doi
035    __
$a (PubMed)35465726
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Yanagisawa, Takafumi $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, The Jikei University School of Medicine, Tokyo105-8461, Japan $1 https://orcid.org/0000000274100712
245    10
$a Hematological prognosticators in metastatic renal cell cancer treated with immune checkpoint inhibitors: a meta-analysis / $c T. Yanagisawa, K. Mori, S. Katayama, H. Mostafaei, F. Quhal, E. Laukhtina, P. Rajwa, RS. Motlagh, A. Aydh, F. König, NC. Grossmann, B. Pradere, J. Miki, M. Schmidinger, S. Egawa, SF. Shariat
520    9_
$a Aim: We aimed to assess the prognostic value of pretreatment hematological biomarkers in patients with metastatic renal cell carcinoma (mRCC) treated with immune checkpoint inhibitors (ICIs). Methods: PubMed, Web of Science and Scopus databases were searched for articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results: Fifteen studies comprising 1530 patients were eligible for meta-analysis. High levels of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein and lactate dehydrogenase were significantly associated with worse progression-free survival. High NLR and PLR were significantly associated with worse overall survival. Conclusion: High pretreatment NLR and PLR appear to be hematological prognostic factors of progression and overall mortality in mRCC patients treated with ICIs. These findings might help in the design of correlative biomarker studies to guide the clinical decision-making in the immune checkpoint inhibitor era.
650    _2
$a biologické markery $7 D015415
650    12
$a karcinom z renálních buněk $x diagnóza $x farmakoterapie $7 D002292
650    _2
$a lidé $7 D006801
650    _2
$a inhibitory kontrolních bodů $x terapeutické užití $7 D000082082
650    12
$a nádory ledvin $7 D007680
650    _2
$a lymfocyty $x patologie $7 D008214
650    _2
$a neutrofily $x patologie $7 D009504
650    _2
$a prognóza $7 D011379
655    _2
$a časopisecké články $7 D016428
655    _2
$a metaanalýza $7 D017418
655    _2
$a přehledy $7 D016454
700    1_
$a Mori, Keiichiro $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, The Jikei University School of Medicine, Tokyo105-8461, Japan $1 https://orcid.org/0000000261476569
700    1_
$a Katayama, Satoshi $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, Okayama University Graduate School of Medicine, Dentistry & Pharmaceutical Sciences, Okayama, 700-8558, Japan $1 https://orcid.org/0000000283772457
700    1_
$a Mostafaei, Hadi $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, 5166, Iran $1 https://orcid.org/0000000155961771
700    1_
$a Quhal, Fahad $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, King Fahad Specialist Hospital, Dammam, 32253, Saudi Arabia $1 https://orcid.org/0000000281636953
700    1_
$a Laukhtina, Ekaterina $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Institute for Urology & Reproductive Health, Sechenov University, Moscow, 119991, Russia $1 https://orcid.org/0000000289530272
700    1_
$a Rajwa, Pawel $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, Medical University of Silesia, Zabrze, 41-808, Poland $1 https://orcid.org/0000000340736584
700    1_
$a Motlagh, Reza S $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Men's Health & Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran $1 https://orcid.org/0000000238199911
700    1_
$a Aydh, Abdulmajeed $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, King Faisal Medical City, Abha, 614312, Saudi Arabia $1 https://orcid.org/0000000160786816
700    1_
$a König, Frederik $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, University Medical Centre Hamburg-Eppendorf, Hamburg, 20251, Germany $1 https://orcid.org/0000000233879029
700    1_
$a Grossmann, Nico C $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Department of Urology, University Hospital Zurich, Zurich, 8091, Switzerland $u Department of Urology, Luzerner Kantonsspital, Lucerne, 6004, Switzerland $1 https://orcid.org/0000000186986461
700    1_
$a Pradere, Benjamin $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $1 https://orcid.org/0000000277688558
700    1_
$a Miki, Jun $u Department of Urology, The Jikei University School of Medicine, Tokyo105-8461, Japan $1 https://orcid.org/0000000246388640
700    1_
$a Schmidinger, Manuela $u Department of Medicine I & Comprehensive Cancer Center, Clinical Division of Oncology, Medical University of Vienna, Vienna, 1090, Austria
700    1_
$a Egawa, Shin $u Department of Urology, The Jikei University School of Medicine, Tokyo105-8461, Japan $1 https://orcid.org/0000000291985559
700    1_
$a Shariat, Shahrokh F $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria $u Institute for Urology & Reproductive Health, Sechenov University, Moscow, 119991, Russia $u Division of Urology, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, 19328, Jordan $u Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA $u Department of Urology, Second Faculty of Medicine, Charles University, Prague, 11638, Czech Republic $u Department of Urology, Weill Cornell Medical College, New York, NY 10021, USA $u Karl Landsteiner Institute of Urology & Andrology, Vienna, 1010, Austria $1 https://orcid.org/0000000266276179
773    0_
$w MED00175821 $t Immunotherapy $x 1750-7448 $g Roč. 14, č. 9 (2022), s. 709-725
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35465726 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804134607 $b ABA008
999    __
$a ok $b bmc $g 1821987 $s 1169422
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 14 $c 9 $d 709-725 $e 20220425 $i 1750-7448 $m Immunotherapy $n Immunotherapy $x MED00175821
LZP    __
$a Pubmed-20220720

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...